Senior Structural Biologist

3 weeks ago


San Diego, California, United States Novartis Farmacéutica Full time
About the Role

As a Principal Scientist I in our Structural Biologics department, you will play a key role in supporting experimental structural biology across multiple biotherapeutic programs. Our team is looking for a highly motivated Senior Scientist to work closely with multidisciplinary teams and provide structural data and protein engineering support.

Key Responsibilities:
  • Design, execute, and troubleshoot experiments to determine the structure of multi-protein complexes by X-ray crystallography or CryoEM to support the design and development of novel biotherapeutics.
  • Work collaboratively across experimental and computational groups to address key scientific questions and drive innovation in structural biology.
  • Effectively communicate results to multidisciplinary teams and contribute to overall project strategy as a structural biology representative.
Requirements

To be successful in this role, you will need a PhD degree in biophysics, biochemistry, or a related discipline, with a proven record in experimental structural biology. A minimum of 5 years' experience in common protein purification methods and molecular biology techniques is also required.

You should have demonstrated independent thought and creativity in science, with attention to detail and problem-solving skills. Experience with structural biology methods, including protein crystallization and CryoEM sample preparation, is essential. Strong organizational and time management skills are also necessary to prioritize and coordinate experimental deliverables.

Preferred Qualifications

A background in using AI-based techniques to facilitate protein construct design and engineering would be beneficial. Familiarity with analytical and biophysical methods, such as light scattering and LCMS, would also be an asset.

Why Novartis

We are a global healthcare leader dedicated to discovering innovative medicines that improve and extend people's lives. As a member of our team, you will have the opportunity to make a meaningful contribution to our mission and develop your career in a dynamic and supportive environment.

Our total compensation package includes a competitive salary range of $112,800-$169,200 per year, as well as other benefits, such as restricted stock units, sign-on bonuses, and discretionary awards.



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