Research Scientist, NGS Assay Development Specialist
5 days ago
Takeda Pharmaceutical is seeking a highly skilled Research Scientist to join our Biologics Informatics and Automation team. As a Research Scientist, you will play a key role in the development and optimization of next-generation sequencing (NGS) protocols for library generation, sequencing, and library QC and analysis.
Key Responsibilities- Develop and optimize NGS protocols for library generation, sequencing using Illumina MiSeq/NextSeq platforms, and library QC and analysis.
- Collaborate with cross-functional teams to integrate NGS data with antibody discovery pipelines.
- Establish workflows using NGS in other areas in Global Biologics, including cell line generation, plasmid preparation, and CAR-T design characterization.
- Generate high-quality NGS libraries through rigorous optimization and QC processes.
- Perform DNA library fragment purification using Blue Pippin and analyze the size using Tape Station 4200.
- Library quantification using qubit and qPCR.
- Continuously improve NGS workflows with integration of automation and informatics.
- Deeply understand and troubleshoot NGS experiments to ensure assay robustness and generation of high-quality data.
- Meet established timelines, maintain accurate records of work, and present data at team, departmental, and company-wide meetings.
- PhD degree in Molecular Biology, Biochemistry, or relevant scientific field (or equivalent) with 2+ years relevant experience, or MS with 8+ years relevant experience, or BS with 10+ years relevant experience.
- Minimum 3 years of industry experience of hands-on NGS library generation and operating Illumina sequencing platform is required.
- A deep understanding of molecular biology with a focus on RNA isolation, cDNA synthesis, PCR amplification, SPRI bead-based clean-up, and fragment analysis knowledge is a must.
- Demonstrated ability to design NGS primers and strategy to utilize NGS sequencing tools currently available in the organization.
- Experience with single-cell technologies (10X, BD Rhapsody) is a plus.
Takeda Pharmaceutical is a patient-focused company that is transforming patient care through the development of novel specialty pharmaceuticals and best-in-class patient support programs. We are a global top employer and offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.
We are committed to equitable pay for all employees and strive to be more transparent with our pay practices. For this role, the estimated salary range is $108,500.00 - $170,500.00, and U.S.-based employees may be eligible for short-term and/or long-term incentives, medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others.
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state, and local laws, and any other characteristic protected by law.
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