Research Scientist II, Gene Editing Specialist

4 days ago

Durham, North Carolina, United States ReCode Therapeutics, Inc Full time
About the Role

We are seeking a highly skilled and motivated Gene Editing Research Scientist to join our team at ReCode Therapeutics, Inc. in Durham, NC. As a key member of our gene correction drug development team, you will be responsible for applying advanced gene editing technologies to support our pipeline of therapies for severe life-limiting diseases.

Key Responsibilities
  • Design, execute, and analyze experiments using next-generation gene editing and epigenome editing strategies with CRISPR-based tools and beyond.
  • Advance gene correction applications for therapeutic and non-viral platform discovery projects through the design, implementation, and execution of molecular biology, cell biology, and NGS-based assays.
  • Support the discovery of novel LNP delivery solutions through in vitro and in vivo gene editing screens.
  • Work with primary in vitro cell culture disease models of lung epithelial cells.
  • Generate, manage, evaluate, and maintain critical data in a highly organized manner, providing statistical analysis and troubleshooting where appropriate.
  • Analyze and present experimental data to a wide range of audiences.
  • Troubleshoot and dissect published literature to find novel solutions to resolve technical and/or biological hurdles.
  • Contribute as a key member of a cross-functional drug discovery team that includes gene correction, primary human biology, pharmacology, computational biology, bioanalytical, toxicology, and formulation capabilities.
  • Prepare SOPs, keep excellent electronic lab notebook and record-keeping entries, and prepare reports and/or manuscripts for publication.
  • Manage one or more direct reports; mentor additions to the team.
Requirements
  • PhD in molecular biology, cell biology, biological engineering, or related discipline with 4 years of experience in postdoctoral research and/or industry.
  • Subject matter expertise, with a proven track record of publications/patents, in gene editing, with a broad knowledge of gene editing applications.
  • Hands-on experience using gene editing tools, including next-generation CRISPR systems (e.g., Prime or Base editors).
  • Deep expertise in analytic RNA or DNA assays to measure and analyze gene editing results.
  • Experience in utilizing bioinformatics tools and software for the analysis of gene editing readouts.
  • Experience in mammalian cell and tissue culturing is required.
  • Experience with viral or non-viral delivery platforms, preferably lipid nanoparticles (LNPs), is recommended.
  • Understanding of lung biology and/or rare lung disease is recommended.
  • Excellent verbal and written communication skills, with proven ability to write reports and/or articles for publication.
  • Advanced knowledge of statistical and genome analytical tools (GraphPad, R, SnapGene).
  • Excellent project leadership skills in driving for results and innovation; ability to execute within a matrixed organization.
  • Extremely organized and able to efficiently manage your time and workflow, including skillfully prioritizing both long-term projects and day-to-day responsibilities.
  • Highly collaborative, team-oriented, and considerate of the needs of others.
  • Desire to work in a fast-paced environment and contribute to developing the next generation of gene editing.
What We Offer
  • No premium cost for employees - 100% subsidized by ReCode for full-time employees.
  • Company 401k contribution.
  • 15 days of company-paid holidays, including a holiday shutdown (usually the last week of the year).
  • Mental health support for employees and their families.
  • FSA available, including a lifestyle spending account subsidized by company.
  • Employee discounts at hotspots.

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