Research Scientist II Gene Editing

7 days ago

Durham, North Carolina, United States ReCode Therapeutics, Inc Full time
About ReCode Therapeutics

We are a clinical-stage genetic medicines company using precision delivery to power the next wave of mRNA and gene correction therapeutics. Our proprietary Selective Organ Targeting (SORT) lipid nanoparticle (LNP) platform enables highly precise and targeted delivery of genetic medicines directly to the organs, tissues, and cells implicated in disease, enabling improved efficacy and potency.

Job Summary

We are seeking a skilled and motivated gene editing scientist to join our Durham, NC location, dedicated to gene correction drug development targeting rare diseases of the lung. You will be involved in applying advanced gene editing technologies to support our gene correction programs and delivery discovery platform function.

Responsibilities
  • Lead, design, and execute experiments using next-generation gene editing and epigenome editing strategies with CRISPR-based tools and beyond.
  • Advance gene correction applications for therapeutic and non-viral platform discovery projects through the design, implementation/optimization, and execution of molecular biology, cell biology, and NGS-based assays.
  • Support the discovery of novel LNP delivery solutions through in vitro and in vivo gene editing screens.
  • Work with primary in vitro cell culture disease models of lung epithelial cells.
  • Generate, manage, evaluate, and maintain critical data in a highly organized manner, providing statistical analysis and troubleshooting where appropriate.
  • Analyze and present experimental data to a wide range of audiences.
  • Troubleshoot and dissect published literature to find novel solutions to resolve technical and/or biological hurdles.
  • Contribute as a key member of a cross-functional drug discovery team that includes gene correction, primary human biology, pharmacology, computational biology, bioanalytical, toxicology, and formulation capabilities.
  • Prepare SOPs, keep excellent electronic lab notebook and record-keeping entries, and prepare reports and/or manuscripts for publication.
  • Manage one or more direct reports; mentor additions to the team.
Qualifications
  • PhD in molecular biology, cell biology, biological engineering, or related discipline with 4 years of experience in postdoctoral research and/or industry.
  • Subject matter expertise, with a proven track record of publications/patents, in gene editing, with a broad knowledge of gene editing applications.
  • Hands-on experience using gene editing tools including next-generation CRISPR systems (e.g., Prime or Base editors).
  • Deep expertise in analytic RNA or DNA assays to measure and analyze gene editing results.
  • Experience in utilizing bioinformatics tools and software for the analysis of gene editing readouts.
  • Experience in mammalian cell and tissue culturing is required.
  • Experience with viral or non-viral delivery platforms, preferably lipid nanoparticles (LNPs) (recommended).
  • Understanding of lung biology and/or rare lung disease (recommended).
  • Excellent verbal and written communication skills, with proven ability to write reports and/or articles for publication.
  • Advanced knowledge of statistical and genome analytical tools (GraphPad, R, SnapGene).
  • Excellent project leadership skills in driving for results and innovation; ability to execute within a matrixed organization.
  • Extremely organized and able to efficiently manage your time and workflow, including skillfully prioritizing both long-term projects and day-to-day responsibilities.
  • Highly collaborative, team-oriented, and considerate of the needs of others.
  • Desire to work in a fast-paced environment and contribute to developing the next generation of gene editing.
What We Offer
  • No premium cost for employees - 100% subsidized by ReCode for full-time employees.
  • Company 401k contribution.
  • 15 days of company-paid holidays, including a holiday shutdown (usually the last week of the year).
  • Mental health support for employees & their families.
  • FSA available, including a lifestyle spending account subsidized by company.
  • Employee discounts at hotspots.

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