Senior Biotherapeutics Engineer
5 days ago
We are seeking an experienced protein structure modeling expert to design industry-leading biotherapeutics as part of Pfizer's BioMedicine Design team.
Job SummaryThe successful candidate will join project teams to optimize protein-based therapeutic leads (such as antibodies, multi-specifics, and fusion proteins) in early through late discovery, primarily using protein structure, AI/ML property prediction models, and molecular simulation.
Key Responsibilities- Work with project teams as a primary source of knowledge for structure and AI-based computational analysis of protein biotherapeutic leads and provide optimized designs.
- Effectively communicate results and recommendations to colleagues with diverse scientific backgrounds.
- Evaluate/implement new or improved methods to increase throughput or accuracy of molecular modeling workflows.
- Analyze data sets to discover relationships between protein structure and key pharmaceutical properties.
- Engineer improved general platforms for protein therapeutics and RNA vaccines.
- PhD in biochemistry, chemistry, or a related field and experience in the biopharmaceutical industry.
- Strong track record of protein design and/or property optimization using computational methods (preferably both structure and AI/ML based), including publication.
- Experience using, and probing the limits of, AI tools for protein design and/or property prediction.
- Conducting research projects in a team setting and effective presentation of computational results to scientists with experimental backgrounds.
- Expertise in one or more commonly used protein structure modeling software packages.
- Programming in a Linux environment using Perl, Python, Matlab, Jupyter Notebook, or equivalent tools.
- Working knowledge of bioinformatics tools and databases.
- Working knowledge of antibody structure and function.
- Experience with computational RNA structure prediction and/or property optimization.
- Linux systems administration skills and knowledge of HPC environments.
- Experience with one or more of the following software suites: Schrodinger, Rosetta, Discovery Studio, FoldX, MOE.
- Experience integrating multiple scientific software toolkits to develop new analysis workflows usable by colleagues.
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.
The annual base salary for this position ranges from $99,900.00 to $166,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program.
We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage.
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