Senior Bioconjugation Specialist

3 weeks ago


San Francisco, California, United States Astrix Full time
Senior Scientist Opportunity at Astrix

About the Role:

Astrix is seeking a highly skilled Senior Scientist to contribute to the development of novel therapeutics. As a Senior Scientist, you will be responsible for designing and optimizing bioconjugation processes, purifying and characterizing antibody-drug conjugates, and applying advanced analytical techniques to support drug development.

Key Responsibilities:

  • Develop and optimize bioconjugation protocols for antibodies with linker-payload combinations.
  • Purify and characterize antibody-drug conjugates using techniques such as size-exclusion chromatography (SEC), hydrophobic interaction chromatography (HIC), and ion-exchange chromatography.
  • Analyze and interpret data from analytical techniques, including liquid chromatography-mass spectrometry (LC/MS).
  • Collaborate with multidisciplinary teams to contribute to the discovery and development of novel therapeutics.
  • Enhance skills in reaction setup, route design, and optimization through on-the-job training.

Requirements:

  • Education: Bachelor's, Master's, or PhD in Chemistry, Biochemistry, or a related field.
  • Experience:
  • Proven experience in bioconjugation, purification, and characterization of antibody-drug conjugates.
  • Proficiency in analytical techniques such as HIC, reverse phase (RP), SEC, SDS-PAGE, and UV-Vis spectroscopy.
  • Strong foundation in protein biochemistry and chemistry.
  • Bonus: Experience with biologics analytics and advanced purification techniques.

What We Offer:

  • A dynamic and collaborative work environment.
  • Opportunities for professional growth and development.
  • A competitive salary range of $50-$65/hr.


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