Laboratory Scientist I

2 weeks ago

San Francisco, California, United States Integrated Resources Inc. Full time

Company Overview: Integrated Resources, Inc. is a leading organization with extensive experience in the industry, dedicated to providing strategic workforce solutions that enhance talent management and operational efficiency.

Position Overview

Role Summary:

We are in search of a driven and results-focused individual who takes personal responsibility for their work and excels in a challenging environment. This role is crucial for the successful development and characterization of clinical-scale manufacturing processes for Chimeric Antigen Receptor T-cell (CART) therapies.

The ideal candidate will play a key role in developing and validating analytical techniques for the characterization, release, and stability assessment of CART products. A strong emphasis will be placed on attracting professionals with expertise in multiparametric immunophenotyping utilizing flow cytometry.

  • Contribute actively to the development, validation, and implementation of advanced analytical techniques for the characterization of CART manufacturing processes and products.
  • Provide analytical support for clinical-scale non-GMP/GMP IND-enabling manufacturing operations, including the qualification of in-process and release methods and technical transfer both internally and externally in support of GMP manufacturing and clinical material release.
  • Engage in innovative programs that enhance product characterization technologies.
  • Collaborate effectively within project technical teams to ensure seamless integration at all levels.
  • Exhibit strong accountability along with excellent organizational and interpersonal skills.
  • Maintain high-quality, timely documentation in electronic laboratory notebooks and technical reports.
  • Present findings to scientists and management in internal forums, including technical and project team meetings.
  • Possess industry laboratory experience with various analytical methods for the characterization and GMP release of cell-based or gene therapies, particularly in flow cytometry-related characterization, release, and stability testing.
  • Demonstrate applied knowledge in molecular immunology, T-cell biology, and primary T cell culture, expansion, and characterization.
  • Have familiarity with cGMP regulations and relevant regulatory guidance documents.
  • Conduct laboratory work using qualified instrumentation and perform technical analysis at designated workstations.

Core Competencies:

  • T-cell flow cytometry expertise
  • Understanding of T-cell biology
  • Good laboratory practices (GLP)
  • Responsible for general laboratory and operational support, including logistical management of samples and compounds, supply ordering, and conducting general bench work activities.
Qualifications

Educational Background:
BSc/MSc degree in Immunology or Molecular Biology with a minimum of 3 years of experience in the biotech or biopharma sector, preferably in the development of analytical methods for gene- or cell-based therapies.

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