Scientific Research Director for Microphysiological Systems

4 weeks ago

Frederick, Maryland, United States Laulima Government Solutions Full time

The Laulima Government Solutions team is seeking a highly skilled Scientific Research Director for Microphysiological Systems to support our government customer located in the United States.

About the Role:

We are looking for a talented individual to conduct collaborative research projects on microphysiological systems within the outlined government program or collaborate with other Study Directors on projects or programs under the guidance of leadership.

Key Responsibilities:

  • Conducts collaborative research projects on microphysiological systems within the outlined government program or collaborates with other Study Directors on projects or programs under the guidance of leadership.
  • Efficiently plans, executes, and reports scientific activities conducted in accordance with directives from the Virology Branch.
  • Works with research leadership to conduct research involving infectious diseases caused by Tier 1 viruses, Risk Group 4 viruses, and uncommon viruses.
  • Research areas include, but are not limited to:
    • Microphysiological systems including, but not limited to organ-chips, organoids, 3D bioprinted setups, and other complex, 3-dimensional in vitro systems.
    • Reverse genetics and genomics.
    • Viral life cycle surrogate systems (e.g., viral pseudotyping, VLPs, minigenome and budding systems).
    • Gene knock-in/knock-out studies.
    • Mechanisms-of-action studies.
    • Enzymatic assays.
    • Animal experiments.
    • Virology assays including, but not limited to, TCID50 and plaque assay.
    • DNA/RNA extraction, purification, quantification, transcription, replication, amplification, and mutagenesis, RT-PCR/real-time PCR, microarray.
  • Analysis of viral load in blood and tissue samples using quantitative real-time PCR (one-step and two-step assays).
  • Generate master and working stocks of virus and other microbial agents as directed that are well documented and characterized.
  • Generate study plans using approved templates and SharePoint processes provided prior to initiation of in vitro and in vivo experiments.
  • Generate high-quality interim and final study reports and develop them for timely publication in peer-reviewed journals.
  • Actively participate in practices/processes to enhance data quality and integrity including periodic review of study execution to identify gaps and refine procedures.
  • Supervise more junior staff members in effectively conducting and troubleshooting assays, analyzing and reporting results.
  • Develop and implement training and cross-training programs to assure continuity of operations and scientific core and screening activities.
  • Develop and revise Standard Operating Procedures (SOPs) and methods for laboratory operations.
  • Comply with the NIH Division of Occupational Health and Safety requirement for satisfactory completion of the Biosurety program and Select Agent program.
  • Comply with the physical security, protection of the division's property, protection of information, cyber security, agent protection, control and accountability, safe disposal and waste handling, and personal security guidelines set forth by the division's Biosurety program.
  • Other duties as assigned.

Requirements:

  • Minimum of a Doctorate (PhD, DVM or MD) in Virology or a related field from an accredited college or university.

Preferred Qualifications:

  • Hands-on laboratory experience with and working knowledge of microphysiological systems as documented by a strong publication record.
  • Proven experience and a publication record in conducting virus experiments using organ-chips and/or organoid models.
  • Working knowledge of quality assurance and quality control systems, such as Good Laboratory Practices (GLP).
  • Excellent communication skills with team members and rapport with leadership, and agility to integrate within a diverse team of scientists and non-scientists.
  • Ability to obtain/maintain DoJ Security Risk Assessment (SRA) approval.
  • Ability to work under BSL-4 conditions. Able to wear respiratory protection.

About Laulima Government Solutions:

Laulima Government Solutions is a fast-growing government service provider. Employees enjoy competitive salaries, a 401K plan with company match, medical, dental, disability, and life insurance coverage, tuition reimbursement, paid time off, and 11 paid holidays.

We are an Equal Opportunity/Affirmative Action Employer. We are proud to state that we do not discriminate in employment decisions based on race, color, religion, sex, pregnancy, sexual orientation, gender identity, national origin, age, protected veteran status, or disability status.

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