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Senior Antibody Design Director
2 months ago
We are seeking a highly experienced Senior Antibody Design Lead to join our team at Lawrence Livermore National Laboratory. As a key member of our Microbiology/Immunology group, you will be responsible for overseeing the development of antibody drug products from concept to transition to commercial partners.
Key Responsibilities- Lead Antibody Product Development: Coordinate and lead subject matter experts to explore technical feasibility and strategic aims of potential new antibody products, working with teams responsible for computational antibody design and production and characterization.
- Collaborate with Cross-Functional Teams: Work with R&D teams on new assay development and laboratory technologies, as well as external partners providing reagents, assays, and/or protein production capabilities.
- Develop Product Development Strategies: Define and track complex multi-year project plans, timelines, and budgets, working with project managers to ensure successful product development.
- Prepare Scientific Reports: Summarize results from complex research activities performed onsite and with partner organizations.
- Oversee Laboratory Operations: Work with laboratory directors to oversee recombinant mammalian and bacterial protein expression and purification.
- Interface with Computational Teams: Collaborate with computational teams performing computational design.
- Develop and Maintain Relationships: Establish and maintain relationships with external partners and collaborators.
- Stay Up-to-Date with Industry Trends: Stay current with industry advancements in antibody technology.
- Anticipate Project Shortcomings: Identify potential project shortcomings and direct resources to develop effective solutions to improve efficiency in key areas relevant to antibody design and discovery.
- Lead Collaborative Projects: Initiate and/or lead collaborative projects requiring involvement of the broader scientific community external to LLNL.
- Lead Multi-Location Research Teams: Summarize research results in peer-reviewed journals, leading multi-location research teams.
- Ph.D. in Molecular Biology, Cell Biology, or Related Field: Equivalent combination of education and related experience.
- Advanced Experience in Antibody Product Development: Highly advanced experience in antibody product development for infectious diseases, including experience in antibody generation and development, biomarker development, assay design, and antibody purification.
- Substantial Knowledge of Cell Biology, Molecular Biology, and Biotechnology: Substantial knowledge of cell biology, molecular biology, and biotechnology.
- Expert Laboratory Management: Expertise in laboratory management, including molecular biology and cell biology.
- Substantial Experience with Recombinant Mammalian and Bacterial Protein Expression and Purification: Substantial experience with recombinant mammalian and bacterial protein expression and purification.
- Expert Leadership, Communication, and Project Management Skills: Expert leadership, communication, and project management skills.
- Significant Experience Developing and Managing Workflows: Significant experience developing and managing workflows for high-throughput antibody production and screening platforms.
- Expert Written, Verbal Communication, and Interpersonal Skills: Expert written, verbal communication, and interpersonal skills necessary to deliver presentations, prepare written reports, and interact with a diverse set of scientists, engineers, and other technical and administrative staff.
- Significant Experience with Regulatory Submissions and Compliance: Significant experience with regulatory submissions and compliance.
- Proven Track Record of Leading Cross-Functional Teams: Proven track record of leading cross-functional teams and developing successful product development strategies.
- Expertise in Library Display Technologies: Expertise in library display technologies for high-throughput screening, e.g., mammalian cell-based expression/display, yeast display, and/or other platforms.
- Extensive Experience with Additional Protein Purification and Characterization Techniques: Extensive experience with additional protein purification and characterization techniques.
- Experience Developing and Managing Workflows for Large-Scale Antibody Production: Experience developing and managing workflows for large-scale (batch) antibody production, purification, and characterization.
- Experience with Automated Workflows and Automation Platforms: Experience with automated workflows and automation platforms (e.g., Hamilton robotic liquid handlers).
