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Scientist- Tumor Immunity

1 month ago

California, United States Pfizer, S.A. de C.V Full time

We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place. To fully realize Pfizer’s purpose – Breakthroughs that change patients’ lives – we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals. Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues. Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world. What You Will Achieve As a Scientist, you will be at the center of our operations and you’ll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be part of a team that is addressing the critical task of rejuvenating our pipeline with innovative, differentiated First-In-Class/ Only-In-Class programs in the years to come. This will be addressed by generation of strong data packages from target hypotheses derived from academic outreach and initiatives. You will be an essential member of this team and creatively design and execute key experiments to address the basic and translational biology of novel drug targets, their molecular pathways, and their connection to human disease. You will support projects in one or more therapeutic areas of interest to Pfizer including Immunology, Oncology, Immuno-Oncology, Neurodegenerative Disease, etc. With your deep knowledge in the discipline, you will be an active team member who influences at the project team level. You will be using your scientific judgment to adapt standard methods and techniques by applying prior work experience and consulting others. Your ability to plan will help in preparing short-term work activities on projects. Your creativity in developing novel processes and new ideas will be used frequently. You will undertake mentoring activities to guide your team members. It is your innovative scientific temperament that will help in making Pfizer ready to achieve new milestones and help patients across the globe. We are looking for a highly motivated and organized individual with excellent attention to detail to join the Tumor Immunity Group within the Cancer Immunology Group as a scientist. Candidate will participate in pre-clinical drug discovery and development projects with a focus on Cancer Immunology. How You Will Achieve It Plan and execute mechanistic, PD, and biomarker studies for preclinical-stage therapies and ex vivo assays, including but not limited to multi-parameter flow cytometry, target expression analysis, and myeloid/NK cell based functional assays. Handling and differentiation of primary cells (NK cells, monocytes, macrophages) and established tumor cell lines. Accurately record experimental protocols/results in detail for use in technical reports. Present results within a multidisciplinary team environment. Qualifications Must Have BSc between 6 to 8 years of experience OR MSc with 4-to-6-year experience. Experience culturing primary cells and established tumor cell lines. Experience planning and executing functional immune assays. Experience using multi-color flow cytometry to immunophenotype murine and human cells from blood and tissues, measure analytes in serum, plasma, supernatant or cell lysates. Excellent organization and planning skills, the ability to work in a fast-paced environment independently and as part of a team, good verbal and written communication, and strong motivation with dedicated work ethics. Nice To Have Experience assessing functionality of NK cells in vitro. Experience working in matrix teams of scientists to deliver defined objectives. PHYSICAL/MENTAL REQUIREMENTS Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis. Must be able to wear specialized protective clothing and PPE (e.g., lab coat, safety shoes, safety glasses). NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS Must be willing and able to work after hours as needed to ensure study integrity. Other Job Details Work Location Assignment: On Premise #J-18808-Ljbffr