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Medical Director
4 months ago
**Medical Director / Senior Medical Director, APOL1 Project Team Leader**
at Maze Therapeutics South San Francisco **We Are Genetic Navigators** bringing together passionate, creative and dedicated professionals to join a rapidly growing biotech in our mission to translate novel genetic insights into lifesaving medicines.
**We are seeking** an experienced Director/Senior Medical Director who will provide strategic and tactical medical leadership and oversight of clinical trials in rare diseases and in genetic subsets of common diseases. This position will serve as the clinical lead and project team leader of the APOL1 chronic kidney disease program as well as support broader clinical development efforts across the pipeline. This individual will be accountable for setting the early development strategy and driving clinical execution of a small molecule targeting APOL1, an important genetically defined driver of chronic kidney disease. This position will also support execution of multiple ongoing and planned phase 1 and phase 2 studies of a small molecule against GYS1, a validated target for Pompe disease, and play a role in business development and licensing decisions. This individual must have the ability to work in a fast-paced, team-oriented, start-up environment to oversee all aspects strategic planning as well as oversight of nonclinical activities. The successful candidate will serve in a highly visible, cross-functional leadership role requiring an ability to be a liaison with senior management, functional leaders, and technical leaders in drug discovery, translational science, and clinical development.
The position will report to the Chief Medical Officer and will be a key member of the development leadership team.
**Responsibilities:**
* Lead all aspects of the APOL1 project team, taking the development compound through IND enabling studies, first in human studies, and defining the strategy to clinical proof of concept and global registration
* Serve as medical monitor for the APOL1 early development studies, and support medical oversight of other clinical stage assets at Maze, including Phase 1 and Phase 2 studies of a GYS1 inhibitor for Pompe disease
* Partner with Clinical Development Operations to identify and select study investigators and sites, and build strong professional relationships with study investigators.
* Interact with patient advocacy groups and community engagement leaders to build awareness and enthusiasm for Maze pipeline assets
* Serve as internal and external project champion through interactions with Maze senior leadership, Maze board of directors, academic experts, steering committees, and patient groups
* Be primary clinical author on key clinical-regulatory documents including study protocols, investigator brochures, general investigational plans, annual safety reports, regulatory briefing packages, INDs, and NDAs
* Oversee pharmacovigilance activities across pipeline
* Over time, build, mentor, and manage a clinical team of medical directors to support Mazes pipeline including a broad range of therapeutic indications and modalities
* Partner with Clinical Development Operations to identify, select, and oversee vendors and CROs to support program needs
* Participate in due diligence activities for potential in-license assets and support intelligence activities for competitor assets
* Develop and integrate timelines and budgets for nonclinical and clinical activities with overall company timelines and goals, in close coordination with project management, CMC, nonclinical development, regulatory affairs, and other stakeholders
* Proactively identify nonclinical risks to Maze programs and develop risk mitigation plans
* Collaborate closely with key cross-functional colleagues to ensure preclinical and clinical studies are conducted with the rigor and documentation required to support global marketing approvals
* Contribute to the development and maintenance of a positive team-focused company culture and champion Maze values through sharp and thoughtful leadership
**Requirements:**
* MD with a minimum of 5-10+ years of relevant industry experience, including experience as a clinical study medical monitor
* Board eligibility/certification and clinical experience and/or fellowship in nephrology is highly desired
* Experience with the preparation and submission of study protocols, INDs, statistical analysis plans, and Investigator Brochures
* Track record of early development leadership on multiple programs resulting in important go/no go decision-making
* Experience in the oversight of early-stage and/or registration-enabling clinical global clinical development programs including CRO, site, and vendor selection and relationship building with investigators/site study staff, advocacy groups, and other third parties
* Direct experience setting patient advocacy strategy and leading successful interactions with patient advocacy groups and patient leaders
* Management experience, particularly in areas of team building, professional development, and mentorship of more junior staff is desired
* Strong leadership and communication skills to translate corporate objectives into action plans that effectively and consistently deliver high quality data on time and on budget
* Ability to adapt quickly to changing environments and priorities
* Positive and enthusiastic disposition and high personal and ethical standards in approaching corporate goals
* Ability to travel domestically and internationally for vendor visits, industry conferences, regulatory meetings, advisory board, and other ad hoc meetings as required
Location (City) * **Voluntary Self-Identification**
For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely **voluntary**. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.
As set forth in Maze Therapeuticss Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.
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If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:
A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.
A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.
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An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.
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