Scientist I, Process Development

3 weeks ago

Hayward, United States Arsenal Biosciences Full time

ArsenalBio, a privately held, clinical-stage programmable cell therapy company engineering advanced CAR T therapies for solid tumors, is seeking a talented Scientist I to work onsite based in our Hayward office.ArsenalBio’s mission is to develop efficacious and safe cellular therapies for patients with chronic diseases, initially cancer. With our programmable and computationally driven approach, our team is engineering living medicines to attack cancer’s inherent multi-faceted nature and overcome the challenges of addressing solid tumors with cell therapy.Driven by a collective of diverse experts across immunology, synthetic biology, molecular biology, automation and computational biology, we are united in purpose to deliver radical breakthroughs for people with cancer, and prioritize the team’s outcomes over individual goals to achieve our company mission - together.We are seeking a talented and motivated Scientist I to join Arsenal Bioscience’s Process Development team. This individual will work closely with team members to develop GMP-compatible processes and procedures that will lead to the effective manufacture of our cell therapy products. This position will report into the Process Development team lead and aid in the technical development of a GMP-enabling cell therapy manufacturing process. The individual will also interact cross-functionally within Process Development, Technical Operations, and across the organization to enable the success of Arsenal Biosciences.
- What You Will Do:

- Independently plan, execute, analyze, and report on experiments to support the development of a GMP process to successfully manufacture T cell therapy products
- Author and compile documentation (protocols, study reports, etc.) to facilitate transfer of Arsenal Biosciences’s process to manufacturing
- Organize, communicate, and present complex data sets to key stakeholders and senior management
- Actively engage in cross-functional collaboration to enable effective project execution and overcome challenges
- Proactively explore and evaluate emerging technologies to improve and optimize the cell therapy manufacturing process, with a focus on optimizing non-viral gene delivery

What Will You Bring:

- PhD, Masters (with 5+ years experience), or Bachelors (with 7+ years experience) in a relevant scientific discipline such as Biotechnology, Bioprocess engineering, Immunology, Molecular Biology, or Biochemistry
- Proficiency with aseptic mammalian cell culture techniques
- Experience in immune cell isolation, T cell activation, expansion, and/or gene editing
- 2+ years of relevant research experience in T cell biology and/or immunotherapy
- Prior experience in cell therapy and/or process development teams
- Expertise in multi-color flow cytometry analyses including panel design and data analysis
- Experience in T cell functional assays including cytotoxicity, cytokine/chemokine, and proliferation is a plus
- Understanding of cGMP environment, Design of Experiment (DOE), and Quality by Design (QBD) principles for process and assay development, qualification, and validation is a plus
- Demonstrated ability to work well in a highly collaborative team environment and coordinate tasks across multiple projects to meet deadlines
- Creative approach to problem-solving and ability to think outside the box

**What We Will Offer You**:

- An opportunity to work with the best talent in the field of cell therapy, and be part of ONE TEAM to advance therapies to patients who need it most.ArsenalBio has a generous and comprehensive benefits package that includes but is not limited to medical, dental, and vision as well as mental health resources, virtual and telehealth options, coaching, infertility treatment, parental leave and health savings accounts. We also offer flexible work schedules and flexible time off, which includes two extra “Arsenal Days of Rest” every quarter for employees to recharge.We have a robust mentorship program, and comprehensive development tools to help employees take control of their career paths and grow into their best selves. ArsenalBio believes in investing in the well-being of our employees - both at work and at home, as they are our greatest asset. They bring scientific talents in molecular biology, immunology, pharmacology, protein chemistry, computational biology, automation, genome engineering, software and other fields to make the future happen now.We are committed to hiring the best talent from diverse backgrounds. A diverse workforce engenders richness of thought, creativity and discovery. We invite individuals who embrace intellectual achievement to bring their unique personal and professional journeys and together we will build transformative cell therapies for cancer patients.We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran s

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