Scientist - in Vivo Pharmacology - Preclinical

3 weeks ago

San Diego, United States Capricor Inc Full time

**Position**:Scientist - In vivo Pharmacology - Preclinical

**Responsibilities**:

- Work with the Associate Director, providing in vivo pharmacology expertise.
- Plan, execute and manage in vivo studies, including protocol development, dosing and tissue collection, study monitoring, bio sample management, tissue processing and relevant data analysis.
- Proficient in administering substances by intravenous (IV) -MUST-, intraperitoneal (IP), subcutaneous (SC), intramuscular (IM) and Intertumoral (IT) injections.
- Execute cell-based assays and experiments of tissues from in vivo studies, perform analyses, and report results.
- Conduct survival surgeries to establish various rodent models using aseptic techniques.
- Develop, characterize and implement new animal models to improve the effectiveness of in vivo pharmacology studies.
- Maintain detailed documentation of all studies in lab notebook to ensure data integrity and traceability
- Optimize and implement best practices for in vivo research methodologies, including animal model selection, dosing strategies, sample collection and data collection techniques
- Ensure compliance with regulatory guidelines and ethical standards in the conduct of in vivo studies
- Evaluate and implement new technologies and platforms to enhance the efficiency and quality of in vivo studies
- Perform and analyze preclinical imaging studies (IVIS)
- Contributes to a team culture that promotes continuous improvement, ownership, professional growth, and inclusion
- Other required duties as may be assigned

**Requirements**:

- DVM or Ph.D. with expertise in nonclinical operations in a drug discovery and development setting
- Broad and extensive expertise with all aspects of in vivo rodent research (various dosing routes, anesthesia, surgical procedures, necropsy, tissue processing, etc.)
- 3Rs-centered, welfare-oriented approach to animal-based research
- Strong communication skills, essential for effective collaboration with cross-functional teams and CROs used for outsourced studies
- Exceptional organizational and attention to detail skills, with the capacity to work autonomously as well as in a team setting
- Ability to troubleshoot and effectively solve problems in a timely and efficient manner, demonstrating resourcefulness and a high level of analytical thinking
- Hands-on experience with cell biology techniques (RNA/DNA extraction, PCR, Western Blot, ELISA, small molecule/biologics interventional assays)
- Experience working across diverse therapeutic modalities, including small molecules, biotherapeutics, nucleic acid therapeutics, and gene therapy is desirable
- Experience analyzing age-related diseases/deficits in animal models; including inflammation, metabolic disorders, neurodegeneration, muscle atrophy, bone loss and/or joint deficits
- Experience with metabolic chambers, behavioral assay and analysis is a desirable.

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