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Scientist, in Vivo Pk

3 months ago

South San Francisco, California, United States Sutro Biopharma Full time

Position Overview:

Sutro Biopharma, Inc.

is looking for a highly motivated individual with exceptional proficiency in designing and executing in vivo pharmacokinetic models, skills in drug administration by multiple routes, and plasma and tissue sample collection.

The Scientist conceives experimental strategies and leads the design and conduct of experiments in biological systems to characterize the pharmacokinetics and tissue distribution of potential therapeutics to prioritize them for further development.

This individual possesses knowledge of relevant experimental biology techniques, including pharmacokinetic and metabolism methodologies; participates in technology development in the area of in vitro assays, cell biology, or in vivo testing; interprets, and communicates experimental findings and documents according to approved policy; maintains broad knowledge of state-of-the-art principles and theories, and develops and analyzes new product concepts by reviewing preclinical and clinical literature; mentors and guides junior scientists and may manage research associates.

This position contributes to and supports the company's research and development efforts to create high-value therapeutics to address unmet medical needs.


Responsibilities:

  • Conduct in vivo pilot toxicology and pharmacokinetic studies of small molecules and biologics in rodent models.
  • Grow tumor cells, implant cells into animals and perform PK-PD studies.
  • Performs necropsy and tissue harvesting.
  • Comply with IACUC and AAALAC regulations by renewing, amending, and developing protocols.
  • Understand and implement study protocols according to IACUC guidelines.
  • Expertise in handling and dosing rodents and administering test articles via various routes.
  • Prepares basic formulations and dosing solutions.
  • Maintain study records/files, provide written materials and methods sections for technical reports.
  • Manage samples (including receipt from external parties and inhouse)
  • Able to work and solve problems independently (i.e., without direct supervision) on routine work.
  • May supervise, mentor, and train junior personnel.
  • Act as a principal investigator in conducting inhouse and CRO studies, including but not limited to generating SOW's, protocol generation/review, and monitoring study progression.
  • Work collaboratively with teams across multiple functions.
  • Plan and budget for animal procurement.
  • Required to work occasionally on weekends and Holidays.

Qualifications:

  • A BA or BS in biological science is required; an MS or PhD in a scientific discipline is a plus.
  • A minimum of 8+ years of in vivo PK studies in small animals. Experience with large animals is not required but is a plus.
  • Understands rodent physiology and anatomy.
  • Former membership of IACUC is a must.
  • Demonstrates superior organizational skills.
  • Being resourceful is a requirement.
  • Familiar with PK-PD animal models.
  • Familiarity with Health Hazard Classes is required.
  • Working experience with ADC, PEGylated molecules, and small molecules is preferred.
  • Familiar with relevant FDA and ICH guidances.
***Sutro Biopharma, Inc. encourages all colleagues to be fully vaccinated for COVID-19 prior to the first date of employment.


As an equal opportunity employer, we believe in fostering a culture that is inclusive and values diversity in background and opinions.

Sutro Biopharma hires extraordinary individuals into every position in the company and is committed to the diversity of our team.

Our company progresses without regard of race, ethnicity, gender, sexual orientation, religious belief, age, disability or citizenship status. We are dedicated to creating a safe environment where our employees can grow and succeed together.

**About Sutro Biopharma