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Scientist I, Purification Development
4 months ago
Company Description
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.
Job Description
The Biologics CMC Development team at AbbVie in the Bay Area has a long and rich history of biologics development. Now located in a new state of the art facility in South San Francisco, the team leverages its comprehensive end-to-end CMC capabilities to work collaboratively through all phases of CMC development with a primary focus on advancing complex biologic therapies, such as bi-specifics and novel modalities, to human clinical studies and eventual licensure. This Scientist I role is within a team of highly experienced scientists and managers who have directly enabled the development/IND submissions of 20+ novel oncology drugs and successfully filed two BLAs.
This position is an onsite role in a lab-based function. To be successful candidates must enjoy and thrive in an onsite, highly collaborative lab environment with daily face-to-face cross-functional interactions between scientists.
Responsibilities include:
Develop, optimize, and scale-up purification processes
Support transfer processes to GMP manufacturing site for clinical material production
Work efficiently, collaboratively, and cross-functionally toward project timelines and goals
Work with contract labs and carry out viral clearance studies
Write technical reports
Author and deliver technical presentations
Qualifications
Basic:
Bachelor’s Degree or equivalent education and typically 5 years of experience and MS or equivalent education and typically 2 years of experience
Must have protein purification experience including chromatography separations and filtration operations
Must have excellent attention to detail and ability to keep detailed written records
Demonstrated ability to independently design, execute and interpret critical experiments to answer scientific questions
Demonstrated ability to learn, understand and master new experimental techniques
Able to work collaboratively within and outside of the group
Able to author technical reports and presentations
Has understanding of biochemistry and bioprocess engineering concepts
Has strong planning and analytical skills
Experience with AKTA chromatographic instruments (such as AKTA Avant, AKTA Purifier, AKTA Pure or similar)
Demonstrated scientific writing skills and strong verbal communication skills including scientific data presentations
Has proficiency with Microsoft Office software, ability to learn new software applications
Preferred:
Has hands on experience with executing antibody or antibody-like molecule purification techniques including resin chromatography (affinity, CEX, AEX, MMC), depth filtration, virus filtration, membrane chromatography, and TFF operations.
Has hands on experience with monoclonal antibody or antibody-like molecule purification at GMP, pilot and/or laboratory scale
Understanding of analytical techniques, such as HPLC, LAL, and ELISA
Has hands on experience with high-throughput technologies and automation
Additional Information
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
- This job is eligible to participate in our short-term incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.
AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.
