Senior Scientist, Protein Purification and Characterization

1 week ago

menlo, United States Chantibody Therapeutics Inc. Full time

Chantibody Therapeutics Inc. is a biotech company based in Menlo Park, California that focuses on the discovery and development of transformational therapeutics for unmet medical needs when combating life-threatening diseases, especially cancer. We’ve developed a proprietary AI-guided antibody discovery platform as a solid foundation for innovative biologics with diverse formats (e.g. mAb, bispecific antibody and fusion proteins), and other diverse modalities such as ADC, mRNA, and CART. Well-funded and supported by our unique research, development, and clinical validation ecosystem under our corporate umbrella, the team encompasses industry veterans with proven track records of bringing novel biologics to global clinical trials. We offer a competitive title, salary, and benefit package commensurate with qualified candidates’ experience. Please join us if you are motivated by our shared passion of discovering innovative therapeutics to patients in need, strive towards taking initiative and delivering results, and willing to learn and grow your career with Chantibody.


Qualifications

·      Ph.D. with 3+ years of industrial experience

·      Strong background in protein characterization for developability assessment of therapeutic biologics using multi-

dimensional methods such as SEC, UV/Vis, RP/IEX/HIC/SEC HPLC, DLS/MALS, CE, DSF/DSC. LC-MS would be plus

·      Hands-on experience in chromatographic separation using AF, IEX, HIC, MMC, and SEC

·      Proficient in liquid chromatography with experience in antigen/mAb/bsAb purification and characterization using

various approaches.

·      Working knowledge of expressing biologics from prokaryotic and mammalian system

·      Downstream process development experience and protein formulation experience for biologics would be a plus


Responsibilities

·      Evaluate the developability of therapeutic lead biologics candidates from protein characteristics.

·      Design and execute workflows to enable lead molecule characterization/discovery.

·      Process development of lead molecules

·      Work with CRO to manage external activities.

·      Play an active role in leading and advancing projects for IND enabling

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