Scientist II or Senior Scientist, Pharmacology

Scientist II or Senior Scientist, Pharmacology Kymera Therapeutics invites applications for the Scientist II or Senior Scientist, Pharmacology position. The role focuses on pipeline projects and target validation in inflammation and related therapeutic areas. Who we are Kymera is a clinical-stage biotechnology company pioneering targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Founded in 2016, Kymera has advanced the first degrader into the clinic for immunological diseases and is building an industry-leading pipeline of oral small molecule degraders. How we work PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives. COLLABORATE: We value trust and transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine. BELONG: We recognize our differences, inviting curiosity and inclusivity so that our people are valued, seen, and heard. Responsibilities Design, perform, analyze, interpret, and report cellular and molecular assays for lead optimization and new target discovery projects. Apply standardization principles to assay design, quality control, analysis, and reporting in a drug discovery setting. Develop and validate primary cell-based assays—including those using whole blood, PBMCs, splenocytes, and other immune cells—and optimize these assays for scalability, reproducibility, and automation. Proactively identify and resolve technical and scientific challenges to ensure high-quality data and meet project timelines. Collaborate with cross‑functional teams and present research findings in project meetings. Partner with CROs to advance assay development, transfer, and execution. Review external data for quality and ensure timely uploading to internal databases. Participate in evaluating targets and projects to continually advance the drug discovery pipeline and platform. Maintain accurate records of laboratory procedures and data. Qualifications PhD in Immunology, molecular or cell biology, pharmacology, or a related field with more than two years of industry experience post‑PhD. Candidates with an MS and extensive drug discovery experience will also be considered. Ability to apply biological insights to innovative assay design, development, and execution. Experience with diverse assay formats and modalities, such as RNA analysis (qPCR), endpoint (viability, apoptosis), phenotypic (live cell) assays, protein quantification (Western Blot, JESS, ELISA, MSD, HTRF, AlphaLisa, HIBIT), and protein‑protein interaction assays (NanoBRET, NanoBiT). Extensive expertise in tissue culture with both immortalized cell lines and primary cells, including isolation, differentiation, and functional assays of immune cell subsets. Background in immunology is highly preferred. Familiarity with flow cytometry and gene editing techniques such as CRISPR/Cas9 is highly desirable. Experience with assay automation and scalability is a major asset. Proven ability to work collaboratively within project teams in a fast‑paced environment. Excellent interpersonal and communication skills, with a strong team‑oriented approach. Eagerness and ability to learn new skills and areas as required by project objectives. Experience collaborating with CROs and using electronic lab notebooks (ELN). Compensation Kymera offers a competitive compensation package that recognizes both results and capabilities through market‑based, performance‑driven pay. The anticipated base salary range for this role is $90,000 – $200,000, with eligibility for annual bonus, equity participation, and comprehensive benefits. Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position. Equal Employment Opportunity Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship or any other legally protected class. #J-18808-Ljbffr