Sr. Research Associate

3 weeks ago


Cambridge, United States Third Rock Ventures Full time

Fulcrum Therapeutics is a clinical-stage biopharmaceutical company focused on improving the lives of patients with genetically defined rare diseases in areas of high unmet medical need. Fulcrum's two lead programs in clinical development are losmapimod, a small molecule for the treatment of facioscapulohumeral muscular dystrophy (FSHD) and pociredir, a small molecule designed to increase expression of fetal hemoglobin for the treatment of sickle cell disease and other hemoglobinopathies. The company's proprietary product engine identifies drug targets that can modulate gene expression to treat the known root cause of gene mis-expression.

Description

Reporting to the Head of Hematology Discovery, the Sr. Research Associate / Associate Scientist in Hematology will be a highly innovative and driven scientist who is dedicated to transforming the lives of patients living with hematological diseases. This individual will be responsible for executing high quality and reproducible experiments across multiple projects in the hematology therapeutic area. This diverse and fast-paced role will require cross-functional collaboration, leveraging expertise of both the hematology team and the broader research organization. As an experienced and developing scientist, the Sr. Research Associate / Associate Scientist in Hematology is expected to lead experiments in the lab, as well as be a critical member of project and program teams where they will present data and provide input as the project progress through discovery.

Responsibilities

* Lead in vitro experiments for projects in multiple hematological indications
* Generate and characterize in vitro cell models using primary cells and/or iPSCs
* Perform chemical and genetic perturbations in vitro to identify novel drug targets
* Leverage disease biology and drug discovery expertise to validate targets and build pharmacological relationships across a diversity of pre-clinical models
* Collaborate with high throughput biology, cell modeling, medicinal chemistry, and in vivo pharmacology to advance projects from hypothesis to IND-enabled programs
* Regularly report findings at hematology and discovery group meetings

Qualifications

* BS/MS in life sciences related field with 2+ years industry experience
* Background in primary cell culture and/or iPSC derived cell models
* Experience developing and validating cell-based assays using both pharmacological and genetic perturbation (CRISPR/cas9, siRNA, etc.) methods
* Flow cytometry experience preferred
* Leads by example in the lab, performing experiments designed to validate targets, advance drug leads, and support our development programs
* Experience and effectiveness working in a multidisciplinary team environment with common goals, and operating in a matrixed environment is essential
* Demonstrated attention to detail, strong written and verbal communication skills, and ability to effectively collaborate across groups at all stages of projects
* Ideal candidates are creative problem-solvers with a get-it-done attitude who can thrive independently or as part of a team



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