Director, Next Generation Sequencing

1 week ago

waltham, United States BostonGene Full time

About BOSTONGENE:

BostonGene Corporation pioneers biomedical software for advanced patient analysis and personalized therapy decision-making in cancer treatment. Our solution integrates cutting-edge cancer research and clinical data to empower clinicians in tailoring optimal treatment strategies for individual patients.


Position Overview

The Director of NGS will oversee the next-generation sequencing workflow across the clinical and R&D teams, ensuring the highest standards of quality, efficiency, and innovation. This leadership role demands a strategic thinker with a deep understanding of NGS technologies, exceptional operational management skills, and the ability to drive continuous improvement in a fast-paced, dynamic environment.


Key Responsibilities:

NGS Assay Development & Quality Control:

Develop and standardize NGS test methods for measuring patient samples, including tissue and liquid biopsy-based DNA and RNA-based tests.

Establish and maintain rigorous quality control and quality assurance processes.

Monitor and evaluate performance metrics to ensure the highest quality of sequencing data.

Troubleshoot and resolve technical issues across NGS teams to minimize downtime and maintain operational continuity.

Technology and Innovation:

Stay abreast of the latest advancements in NGS technological and genomic research.

Evaluate and implement new technologies and methods to keep the company at the cutting edge of genomic testing.

Maintain a process of continuous improvement and analytical validation of testing platforms.

Cross-Functional Collaboration:

Work closely with clinical operations, bioinformatics, and R&D teams to ensure seamless integration of NGS tests and data into the BostonGene NGS product portfolio.

Collaborate with external partners, vendors, and regulatory bodies as needed.

Leadership and Strategy:

Develop and execute strategic plans for NGS operations to support the company’s NGS product portfolio, clinical trial support, and R&D assay development goals.

Lead, mentor, and manage a high-performing team of scientists, bioinformaticians, and laboratory technicians.

Foster a culture of innovation, collaboration, and excellence within the NGS teams in the BG laboratory.

Budget and Resource Management:

Develop and manage budgets for NGS assay development, and assay improvements ensuring cost-effective use of resources.

Oversee procurement and maintenance of laboratory equipment and supplies.

Identify and implement cost-saving measures without compromising quality.


Preferred Skills:

  • Next Generation Sequencing: Proficiency with DNA and RNA sequencing from cells, fresh and FFPE tissue, and plasma on Illumina NovaSeq6000 and NovaSeq X-plus.
  • NGS Process Development: Streamline NGS workflows to decrease costs, eliminate errors, and reduce turnaround time.
  • Assay Development & Tech Transfer: Design new NGS tests, improve performance characteristics of existing assays, develop and execute validation plans.
  • Team Management & Effective Communication: Proven ability to coordinate and matrix interdisciplinary teams of scientists, technologists, and bioinformaticians to achieve company goals.
  • Adaptability & Self-Motivation: Proactive and self-driven, with a strong sense of accountability and teamwork. Comfortable working in a fast-paced environment with shifting priorities.
  • Supply Chain Management: Monitor and control reagent inventory, usage, to minimize costs.


Qualifications:

  • Ph.D. or Master’s degree in Molecular Biology, Genetics, Genomics, or a related field.
  • Minimum of 10 years of experience in NGS clinical test development, with at least 5 years in a leadership role.
  • Proven track record of assay development and tech transfer in high-throughput sequencing laboratories.
  • Strong knowledge of NGS technologies, bioinformatics, and genomic data analysis.
  • Excellent leadership, communication, and interpersonal skills.
  • Ability to thrive in a fast-paced, dynamic environment and manage multiple priorities.
  • Strong understanding of regulatory compliance in clinical genomics.

  • Director of Next Generation Sequencing

    4 days ago

    Waltham, Massachusetts, United States BostonGene Full time

    About BostonGeneBostonGene Corporation is a pioneering force in biomedical software, dedicated to advancing patient analysis and personalized therapy decision-making in cancer treatment. Our innovative solution integrates cutting-edge cancer research and clinical data to empower clinicians in tailoring optimal treatment strategies for individual...

  • Director, Next Generation Sequencing

    1 week ago

    Waltham, United States BostonGene Full time

    About BOSTONGENE: BostonGene Corporation pioneers biomedical software for advanced patient analysis and personalized therapy decision-making in cancer treatment. Our solution integrates cutting-edge cancer research and clinical data to empower clinicians in tailoring optimal treatment strategies for individual patients.Position OverviewThe Director of NGS...

  • Director, Next Generation Sequencing

    1 week ago

    Waltham, United States BostonGene Full time

    About BOSTONGENE: BostonGene Corporation pioneers biomedical software for advanced patient analysis and personalized therapy decision-making in cancer treatment. Our solution integrates cutting-edge cancer research and clinical data to empower clinicians in tailoring optimal treatment strategies for individual patients.Position OverviewThe Director of NGS...

  • Sr. Director Laboratory Operations

    3 weeks ago

    waltham, United States BostonGene Full time

    Position OverviewThe Senior Director of Laboratory Operations will lead and manage the production of molecular testing products in our high-complexity molecular laboratory, in Waltham, MA. This candidate will supervise the delivery of high-quality, efficient, and innovative molecular diagnostic services to BostonGene customers, collaborators, and internal...

  • Sr. Director Laboratory Operations

    3 weeks ago

    Waltham, United States BostonGene Full time

    Position OverviewThe Senior Director of Laboratory Operations will lead and manage the production of molecular testing products in our high-complexity molecular laboratory, in Waltham, MA. This candidate will supervise the delivery of high-quality, efficient, and innovative molecular diagnostic services to BostonGene customers, collaborators, and internal...

  • Sr. Director Laboratory Operations

    3 weeks ago

    Waltham, United States BostonGene Full time

    Position OverviewThe Senior Director of Laboratory Operations will lead and manage the production of molecular testing products in our high-complexity molecular laboratory, in Waltham, MA. This candidate will supervise the delivery of high-quality, efficient, and innovative molecular diagnostic services to BostonGene customers, collaborators, and internal...

  • Senior Director of Molecular Operations

    3 weeks ago

    Waltham, Massachusetts, United States BostonGene Full time

    Job SummaryWe are seeking a highly experienced and skilled Senior Director of Laboratory Operations to lead our molecular testing operations at BostonGene. The ideal candidate will have a strong background in molecular biology, particularly in high-throughput next-generation sequencing, and a proven track record in operational management.Key...

  • Senior Director of Laboratory Operations and Innovation

    2 weeks ago

    Waltham, Massachusetts, United States BostonGene Full time

    Job SummaryBostonGene is seeking a seasoned leader to serve as the Senior Director of Laboratory Operations and Innovation. This key role will oversee the production of molecular testing products in our high-complexity molecular laboratory, driving continuous improvement and excellence in laboratory operations.Key Responsibilities:Leadership and...

  • Senior Actuarial Analyst

    4 weeks ago

    Waltham, Massachusetts, United States Next Insurance Full time

    Job OverviewLocation: HybridAt Next Insurance, our goal is to empower entrepreneurs. We are revolutionizing the small business insurance landscape through our technology-driven, comprehensive service model, addressing the entire value chain and enhancing customer interactions.Since our inception, we have provided tailored, efficient, and affordable insurance...

  • Senior Director of Laboratory Operations

    7 days ago

    Waltham, Massachusetts, United States BostonGene Full time

    Senior Director of Laboratory OperationsBostonGene is seeking a seasoned leader to oversee the production of molecular testing products in our high-complexity molecular laboratory. As Senior Director of Laboratory Operations, you will lead and manage a multidisciplinary team to deliver high-quality, efficient, and innovative molecular diagnostic services to...

  • Director of Laboratory Excellence

    3 weeks ago

    Waltham, Massachusetts, United States BostonGene Full time

    Job SummaryWe are seeking a highly experienced and skilled Senior Director of Laboratory Operations to lead our molecular testing operations at BostonGene. The ideal candidate will have a strong background in molecular biology, operational management, and leadership, with a proven track record of driving high-quality results in a fast-paced environment.Key...

  • Clinical Laboratory Specialist

    2 weeks ago

    Waltham, Massachusetts, United States BostonGene Full time

    About BostonGeneBostonGene Corporation is a pioneering biotechnology company that specializes in the development of advanced biomedical software for personalized therapy decision-making in the fight against cancer. Our mission is to enable physicians to provide every patient with the highest probability of survival through optimal cancer treatments using...

  • Associate Director of Hardware Engineering

    1 month ago

    Waltham, United States Vicarious Surgical Full time

    Job DescriptionJob DescriptionVicarious Surgical is hiring an Associate Director of Hardware Engineering to join our team in Waltham, MA. This role will be tasked with managing a team of engineers focused on the development of capital equipment and single use disposables associated with our surgical robot. Vicarious Surgical is a next generation robotics...

  • Associate Director of Hardware Engineering

    3 weeks ago

    Waltham, United States Vicarious Surgical Full time

    Job DescriptionJob DescriptionVicarious Surgical is hiring an Associate Director of Hardware Engineering to join our team in Waltham, MA. This role will be tasked with managing a team of engineers focused on the development of capital equipment and single use disposables associated with our surgical robot. Vicarious Surgical is a next generation robotics...

  • Clinical Laboratory Technologist

    4 months ago

    Waltham, United States BostonGene Full time

    About BOSTONGENEBostonGene Corporation is pioneering the use of biomedical software for advanced patient analysis and personalized therapy decision-making in the fight against cancer. BostonGene’s unique solution performs sophisticated analytics to aid clinicians in evaluating viable treatment options for each patient’s individual genetics, tumor and...

  • Clinical Laboratory Technologist

    2 weeks ago

    waltham, United States BostonGene Full time

    About BOSTONGENEBostonGene Corporation is pioneering the use of biomedical software for advanced patient analysis and personalized therapy decision-making in the fight against cancer. BostonGene’s unique solution performs sophisticated analytics to aid clinicians in evaluating viable treatment options for each patient’s individual genetics, tumor and...

  • Clinical Laboratory Technologist

    3 weeks ago

    waltham, United States BostonGene Full time

    About BOSTONGENEBostonGene Corporation is pioneering the use of biomedical software for advanced patient analysis and personalized therapy decision-making in the fight against cancer. BostonGene’s unique solution performs sophisticated analytics to aid clinicians in evaluating viable treatment options for each patient’s individual genetics, tumor and...

  • Clinical Laboratory Technologist

    4 weeks ago

    Waltham, United States BostonGene Full time

    About BOSTONGENEBostonGene Corporation is pioneering the use of biomedical software for advanced patient analysis and personalized therapy decision-making in the fight against cancer. BostonGene’s unique solution performs sophisticated analytics to aid clinicians in evaluating viable treatment options for each patient’s individual genetics, tumor and...

  • Clinical Laboratory Technologist

    4 weeks ago

    Waltham, United States BostonGene Full time

    About BOSTONGENEBostonGene Corporation is pioneering the use of biomedical software for advanced patient analysis and personalized therapy decision-making in the fight against cancer. BostonGene’s unique solution performs sophisticated analytics to aid clinicians in evaluating viable treatment options for each patient’s individual genetics, tumor and...

  • Senior Actuarial Analyst

    4 weeks ago

    Waltham, Massachusetts, United States Next Insurance Full time

    Job OverviewLocation: Hybrid Work EnvironmentAt NEXT, our mission is to empower entrepreneurs by providing innovative insurance solutions tailored for small businesses. We are pioneering a technology-driven, comprehensive approach to small business insurance, enhancing the overall customer experience.Since our inception, we have successfully assisted...