Stem Cell Senior Scientist

1 week ago

boston, United States Ovelle Full time

About the Company:

Ovelle is revolutionizing fertility treatment through human in vitro oogenesis—producing eggs from somatic cells. Our approach uses directed differentiation of human iPSCs to ovarian cell types including granulosa cells and oogonia by manipulating expression of transcription factors and RNA-binding proteins. We are the first company to develop technology to induce meiosis in human iPSCs. By innovating egg production, we aim to make fertility treatments more accessible and affordable. If we are successful, it will mark a paradigm shift in treatments for infertility, and offer a new path to parenthood for millions of people around the world. Come help us build an exciting future all of us want to live in.


About the Specific Role:

We seek a Stem Cell Scientist to lead our efforts in developing and optimizing protocols for deriving granulosa cells and other supporting ovarian cells from human iPSCs. In this role you will lead this effort, which is critical to the success of human in vitro oogenesis. This position offers a unique opportunity to apply your skills in a field with immense potential to impact global health and happiness.


How You Will Contribute:

  • Lead the optimization and execution of the directed differentiation protocol to generate functional ovarian supporting cells from human iPSCs.
  • Design and implement transcription factor screening experiments to identify key regulators of ovarian cell fate.
  • Develop and characterize 3D ovarian organoids (ovaroids) by co-culturing iPSC-derived granulosa-like cells with meiotic oogonia
  • Collaborate with our bioinformatics team to interpret bulk and single-cell RNA sequencing data, contributing to the understanding of ovarian cell development and function.


Qualifications:

  • Ph.D. in Biology, Biochemistry, or a closely related field; or track record of innovation
  • Experience working with human pluripotent stem cells and directed differentiation protocols.
  • Proficiency in genetic engineering techniques, including plasmid design and cloning, CRISPR/Cas9-mediated genome editing, lentiviral/transposon-based gene delivery systems, and pooled library screens.
  • Experience with flow cytometry, fluorescence-activated cell sorting (FACS), and immunofluorescence microscopy, including experimental design and data analysis.
  • Familiarity with sequencing technologies, particularly single-cell RNA-seq, and basic bioinformatics skills for data analysis.
  • Proven track record of successful execution of complex, multi-step cell culture protocols and 3D organoid systems.


Ovelle is a research-first startup where scientists work together on only one deep and important problem: IVG. We operate like a fast, efficient academic lab without constraints. We’re committed to sharing our work with the scientific community and welcome collaborations with academic researchers. 


We are well funded and have future funding commitments. Our people are the heart of our success and our compensation and benefits reflect this. Our culture blends a commitment to rapid innovation with the belief that offering great benefits and perks directly supports scientific progress.


We urge everyone to apply as we believe in encouraging inclusion, acceptance, and understanding by employing individuals who bring unique perspectives to the company.


Our benefits:

  • 12.5 paid holidays
  • 20 days PTO
  • Up to 12 weeks paid leave for new parents who are primary caregivers
  • Perq MBTA pass program 
  • Medical, Dental, and Vision
  • Matching 401(k) plan
  • Tuition reimbursement for work-related continuing education.

  • Stem Cell Senior Scientist

    2 weeks ago

    Boston, United States Ovelle Full time

    About the Company:Ovelle is revolutionizing fertility treatment through human in vitro oogenesis—producing eggs from somatic cells. Our approach uses directed differentiation of human iPSCs to ovarian cell types including granulosa cells and oogonia by manipulating expression of TFs and RNA-binding proteins. We are the first company to develop technology...

  • Stem Cell Senior Scientist

    2 weeks ago

    Boston, United States Ovelle Full time

    About the Company:Ovelle is revolutionizing fertility treatment through human in vitro oogenesis—producing eggs from somatic cells. Our approach uses directed differentiation of human iPSCs to ovarian cell types including granulosa cells and oogonia by manipulating expression of TFs and RNA-binding proteins. We are the first company to develop technology...

  • Stem Cell Senior Scientist

    1 week ago

    Boston, United States Ovelle Full time

    About the Company:Ovelle is revolutionizing fertility treatment through human in vitro oogenesis—producing eggs from somatic cells. Our approach uses directed differentiation of human iPSCs to ovarian cell types including granulosa cells and oogonia by manipulating expression of transcription factors and RNA-binding proteins. We are the first company to...

  • Senior Staff Scientist, Single-Cell Biology

    4 weeks ago

    Boston, United States Kojin Therapeutics Full time

    Senior Staff Scientist, Single-Cell Biology & TranscriptomicsWho we areKojin Therapeutics, Inc. is harnessing groundbreaking discoveries in cell-state and ferroptosis biology to develop first-in-class treatments for use in patients with various forms of cancer, as well as cardiovascular, immunologic, hepatic, and degenerative diseases. Named after the...

  • Senior Staff Scientist, Single-Cell Biology

    2 months ago

    boston, United States Kojin Therapeutics Full time

    Senior Staff Scientist, Single-Cell Biology & TranscriptomicsWho we areKojin Therapeutics, Inc. is harnessing groundbreaking discoveries in cell-state and ferroptosis biology to develop first-in-class treatments for use in patients with various forms of cancer, as well as cardiovascular, immunologic, hepatic, and degenerative diseases. Named after the...

  • Senior Staff Scientist, Single-Cell Biology

    3 weeks ago

    Boston, United States Kojin Therapeutics Full time

    Senior Staff Scientist, Single-Cell Biology & TranscriptomicsWho we areKojin Therapeutics, Inc. is harnessing groundbreaking discoveries in cell-state and ferroptosis biology to develop first-in-class treatments for use in patients with various forms of cancer, as well as cardiovascular, immunologic, hepatic, and degenerative diseases. Named after the...

  • Senior Staff Scientist, Single-Cell Biology

    2 months ago

    Boston, United States Kojin Therapeutics Full time

    Senior Staff Scientist, Single-Cell Biology & TranscriptomicsWho we areKojin Therapeutics, Inc. is harnessing groundbreaking discoveries in cell-state and ferroptosis biology to develop first-in-class treatments for use in patients with various forms of cancer, as well as cardiovascular, immunologic, hepatic, and degenerative diseases. Named after the...

  • Senior Staff Scientist, Single-Cell Biology

    2 months ago

    boston, United States Kojin Therapeutics Full time

    Senior Staff Scientist, Single-Cell Biology & TranscriptomicsWho we areKojin Therapeutics, Inc. is harnessing groundbreaking discoveries in cell-state and ferroptosis biology to develop first-in-class treatments for use in patients with various forms of cancer, as well as cardiovascular, immunologic, hepatic, and degenerative diseases. Named after the...

  • Senior Staff Scientist, Single-Cell Biology

    2 months ago

    Boston, United States Kojin Therapeutics Full time

    Senior Staff Scientist, Single-Cell Biology & TranscriptomicsWho we areKojin Therapeutics, Inc. is harnessing groundbreaking discoveries in cell-state and ferroptosis biology to develop first-in-class treatments for use in patients with various forms of cancer, as well as cardiovascular, immunologic, hepatic, and degenerative diseases. Named after the...

  • Principal Scientist

    2 months ago

    Boston, United States GALY Full time

    We are out of time. Change must be immediate. We have to help the world find alternative ways to produce all the same things we love. But better. Using less land, less water, less energy, and making less waste. If you think that sounds like a mission, well, you are right. We are solving the world's most important problems with talented individuals who share...

  • Pediatric Hematopoietic Stem Cell Program Clinician

    4 days ago

    Boston, Massachusetts, United States Boston Children's Hospital Full time

    Boston Children's Hospital OpportunityWe are seeking a skilled and compassionate Nurse Practitioner/Physician Assistant to join our Hematopoietic Stem Cell Program team.Key Responsibilities:Collaborate with a multidisciplinary team to provide family-centered care and clinical oversight for patients and families in the inpatient setting.Work in a...

  • Senior Scientist

    4 weeks ago

    Boston, United States Pivot Search Full time

    Senior Scientist - Cell-Based and Molecular Biology ServicesLocation: Boston, MAAbout My Client: My client is a leading bioanalytical Contract Research Organization (CRO) dedicated to delivering projects with unmatched quality, scientific rigor, and efficiency. With a robust history of over 30 years in the industry, they excel in the development,...

  • Senior Scientist

    1 week ago

    boston, United States Pivot Search Full time

    Senior Scientist - Cell-Based and Molecular Biology ServicesLocation: Boston, MAAbout My Client: My client is a leading bioanalytical Contract Research Organization (CRO) dedicated to delivering projects with unmatched quality, scientific rigor, and efficiency. With a robust history of over 30 years in the industry, they excel in the development,...

  • Senior Scientist

    2 months ago

    Boston, United States Pivot Search Full time

    Senior Scientist - Cell-Based and Molecular Biology ServicesLocation: Boston, MAAbout My Client: My client is a leading bioanalytical Contract Research Organization (CRO) dedicated to delivering projects with unmatched quality, scientific rigor, and efficiency. With a robust history of over 30 years in the industry, they excel in the development,...

  • Senior Scientist

    2 months ago

    Boston, United States Pivot Search Full time

    Senior Scientist - Cell-Based and Molecular Biology ServicesLocation: Boston, MAAbout My Client: My client is a leading bioanalytical Contract Research Organization (CRO) dedicated to delivering projects with unmatched quality, scientific rigor, and efficiency. With a robust history of over 30 years in the industry, they excel in the development,...

  • Senior Staff Scientist, Single-Cell Biology Expert

    1 month ago

    Boston, Massachusetts, United States Kojin Therapeutics Full time

    About Kojin TherapeuticsKojin Therapeutics is a biotech company harnessing groundbreaking discoveries in cell-state and ferroptosis biology to develop first-in-class treatments for various forms of cancer, cardiovascular, immunologic, hepatic, and degenerative diseases.Job DescriptionWe are seeking an experienced and detail-oriented scientist to establish...

  • Scientist/Senior Scientist

    2 weeks ago

    Boston, United States Dewpoint Therapeutics Full time

    Dewpoint Therapeutics is building a highly collaborative team to harness the power of biomolecular condensates. Together, we are leveraging a transformative shift in the understanding of cellular biology to discover and advance breakthrough therapeutics for the toughest diseases.We are searching for a Scientist or Senior Scientist to join our Discovery...

  • Scientist/Senior Scientist

    1 week ago

    boston, United States Dewpoint Therapeutics Full time

    Dewpoint Therapeutics is building a highly collaborative team to harness the power of biomolecular condensates. Together, we are leveraging a transformative shift in the understanding of cellular biology to discover and advance breakthrough therapeutics for the toughest diseases.We are searching for a Scientist or Senior Scientist to join our Discovery...

  • Scientist/Senior Scientist

    1 week ago

    Boston, United States Dewpoint Therapeutics Full time

    Dewpoint Therapeutics is building a highly collaborative team to harness the power of biomolecular condensates. Together, we are leveraging a transformative shift in the understanding of cellular biology to discover and advance breakthrough therapeutics for the toughest diseases.We are searching for a Scientist or Senior Scientist to join our Discovery...

  • Scientist/Senior Scientist

    2 weeks ago

    boston, United States Dewpoint Therapeutics Full time

    Dewpoint Therapeutics is building a highly collaborative team to harness the power of biomolecular condensates. Together, we are leveraging a transformative shift in the understanding of cellular biology to discover and advance breakthrough therapeutics for the toughest diseases.We are searching for a Scientist or Senior Scientist to join our Discovery...