Stem Cell Senior Scientist

1 week ago

Boston, United States Ovelle Full time

About the Company:

Ovelle is revolutionizing fertility treatment through human in vitro oogenesis—producing eggs from somatic cells. Our approach uses directed differentiation of human iPSCs to ovarian cell types including granulosa cells and oogonia by manipulating expression of transcription factors and RNA-binding proteins. We are the first company to develop technology to induce meiosis in human iPSCs. By innovating egg production, we aim to make fertility treatments more accessible and affordable. If we are successful, it will mark a paradigm shift in treatments for infertility, and offer a new path to parenthood for millions of people around the world. Come help us build an exciting future all of us want to live in.


About the Specific Role:

We seek a Stem Cell Scientist to lead our efforts in developing and optimizing protocols for deriving granulosa cells and other supporting ovarian cells from human iPSCs. In this role you will lead this effort, which is critical to the success of human in vitro oogenesis. This position offers a unique opportunity to apply your skills in a field with immense potential to impact global health and happiness.


How You Will Contribute:

  • Lead the optimization and execution of the directed differentiation protocol to generate functional ovarian supporting cells from human iPSCs.
  • Design and implement transcription factor screening experiments to identify key regulators of ovarian cell fate.
  • Develop and characterize 3D ovarian organoids (ovaroids) by co-culturing iPSC-derived granulosa-like cells with meiotic oogonia
  • Collaborate with our bioinformatics team to interpret bulk and single-cell RNA sequencing data, contributing to the understanding of ovarian cell development and function.


Qualifications:

  • Ph.D. in Biology, Biochemistry, or a closely related field; or track record of innovation
  • Experience working with human pluripotent stem cells and directed differentiation protocols.
  • Proficiency in genetic engineering techniques, including plasmid design and cloning, CRISPR/Cas9-mediated genome editing, lentiviral/transposon-based gene delivery systems, and pooled library screens.
  • Experience with flow cytometry, fluorescence-activated cell sorting (FACS), and immunofluorescence microscopy, including experimental design and data analysis.
  • Familiarity with sequencing technologies, particularly single-cell RNA-seq, and basic bioinformatics skills for data analysis.
  • Proven track record of successful execution of complex, multi-step cell culture protocols and 3D organoid systems.


Ovelle is a research-first startup where scientists work together on only one deep and important problem: IVG. We operate like a fast, efficient academic lab without constraints. We’re committed to sharing our work with the scientific community and welcome collaborations with academic researchers. 


We are well funded and have future funding commitments. Our people are the heart of our success and our compensation and benefits reflect this. Our culture blends a commitment to rapid innovation with the belief that offering great benefits and perks directly supports scientific progress.


We urge everyone to apply as we believe in encouraging inclusion, acceptance, and understanding by employing individuals who bring unique perspectives to the company.


Our benefits:

  • 12.5 paid holidays
  • 20 days PTO
  • Up to 12 weeks paid leave for new parents who are primary caregivers
  • Perq MBTA pass program 
  • Medical, Dental, and Vision
  • Matching 401(k) plan
  • Tuition reimbursement for work-related continuing education.

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