Senior Research Associate

1 week ago


lexington, United States Integrated Resources, Inc ( IRI ) Full time

Title: Research Associate

Location: Lexington, MA

Duration: 12 months+


MANAGER MUST HAVES:

1. Cell culture experience and basic cell biology methodologies such as transfection

2. Molecular biology techniques such as RNA extraction and RT-qPCR

3. Vitro model systems including organoids and other 3D culture systems is highly preferred


Purpose:

To provide technical laboratory research effort in support of multiple projects focused on expedited evaluation and the clinical translation of therapies.


Essential Functions:

  • siRNA drug candidate screening, hit identification, and lead optimization
  • Cellular and molecular biology methodologies, e.g., mammalian cell culture; in vitro screening; cell-based assays; RNA extraction and RT-qPCR
  • Analyze data and present the results in group meetings
  • Maintain clear experimental records in laboratory notebooks; write SOPs and other technical reports as needed
  • Work closely with research team members to quickly and effectively address critical questions related to the efficacy of our drugs
  • Review literature and provide insights to research directions, while predominantly making hands-on contributions to the research


Qualifications:

  • Master’s in Cell and Molecular Biology or Pharmaceutical Sciences
  • 0-4 years of relevant drug discovery laboratory experience in industrial or academic environment is preferred
  • Experience in cellular and molecular biology is essential (e.g., mammalian cell culture, cell-based assays, quantitative real-time PCR)
  • Experience with primary human adipocytes and hepatocytes culture is preferred
  • Experience with advanced in vitro model systems including organoids and other 3D culture systems is highly preferred
  • Experience with RNAi and in vitro screening is preferred
  • Candidate must have strong oral and written communication skills, strong work ethics and demonstrated to be an effective contributor to group projects in a team-oriented environment
  • The ability to perform and interpret experiments reliably, and to advance projects aggressively towards defined goals is expected



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