Research Associate, High Throughput Analytics
1 month ago
Verve is a clinical-stage genetic medicines company established with a mission to solve the global health epidemic of cardiovascular disease. Founded by world-leading experts in cardiovascular medicine, human genetics and gene-editing, Verve is pioneering a new approach to the care of cardiovascular disease, potentially transforming treatment from chronic management to single-course gene editing medicines. The company's initial three programs – VERVE-101, VERVE-102, and VERVE-201 – target genes that have been extensively validated as targets for lowering low-density lipoprotein cholesterol (LDL-C), a root cause of cardiovascular disease. VERVE-101 and VERVE-102 are designed to permanently turn off the PCSK9 gene in the liver and are being developed initially for heterozygous familial hypercholesterolemia (HeFH) and ultimately to treat atherosclerotic cardiovascular disease (ASCVD) patients not at goal on oral therapy. VERVE-201 is designed to permanently turn off the ANGPTL3 gene in the liver and is initially being developed for homozygous familial hypercholesterolemia (HoFH) and ultimately to treat patients with refractory hypercholesterolemia. In 2023, Verve was named a Top Place to Work by The Boston Globe for the third consecutive year. Verve is headquartered in Boston, Massachusetts.
The PositionVerve is seeking a Research Associate to contribute to a team of high throughput analytics, supporting teams across Verve Therapeutics using analytical methods and technologies to characterize mRNA, gRNA and LNP drug products in Verve's growing gene editing pipeline. The position will be part of an integrated R&D team that aims to advance preclinical gene editing candidates into the clinic and work closely with discovery, process development and internal quality control group.
Job Responsibilities- Train on and execute analytical tests to characterize proteins, gRNAs, mRNAs, and lipid nanoparticle (LNP) drug products using a number of assays, including Capillary Electrophoresis, UPLC, DLS, ELISA, DNA/RNA extraction from tissues/cells, PCR/NGS library preparation, real time PCR and reverse transcription using state-of-the-art analytical instruments.
- Work across the ARD team and cross-functionally to execute complex characterization studies.
- Work with key partners across Verve (discovery research, preclinical, process development) to provide data and reports from in-process testing and final product characterization.
- Develop and revise analytical test methods, as well as qualification protocols and reports.
- Summarize and present data to audiences from junior team members to senior leadership.
- Other duties as assigned.
- Bachelor's degree in chemistry, biophysics, biochemistry, bioengineering, or related life sciences field with strong scientific background and 1+ years relevant industry experience
- Demonstrated competency in operating HPLC/UPLC/CE instrumentation.
- Hands-on experience in oligonucleotide and lipid characterization is a plus.
- Hands-on experience in liquid handling automation platforms (Hamilton, TECAN, Beckman, etc) and open-access chromatography systems is a plus.
- Strong change and learning agility and confidence to show scientific creativity.
- Ability to be nimble and thrive in a fast-paced, dynamic culture and environment.
- Ability to work by influencing peers and working collaboratively while executing multiple priorities in the delivery of projects.
Don't check off every box in the requirements listed above? Please consider applying anyway. We want the best candidates for the job, and those candidates don't always meet 100% of the qualifications listed. At Verve, we are dedicated to building diverse and inclusive teams who embody the values we share: grit, spirit, drive, and passion. We look forward to learning more about your unique background.
EEO StatementVerve Therapeutics is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. If you have a disability or special need that requires accommodation, please let us know.
Recruitment & Staffing AgenciesVerve Therapeutics does not accept agency resumes unless contacted directly by internal Verve Talent Acquisition. Please do not forward resumes to Verve employees or any other company location; Verve Therapeutics is not responsible for any fees related to unsolicited resumes.
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Boston, United States Verve Therapeutics, Inc. Full timeJob DescriptionJob DescriptionThe CompanyVerve is a clinical-stage genetic medicines company established with a mission to solve the global health epidemic of cardiovascular disease. Founded by world-leading experts in cardiovascular medicine, human genetics and gene-editing, Verve is pioneering a new approach to the care of cardiovascular disease,...
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