Current jobs related to Senior Bioinformatics Scientist - Watertown - Acrivon Therapeutics
-
Senior Scientist
1 week ago
Watertown, Massachusetts, United States Stratacuity: Proven Scientific Placement Full timeJob Title: Senior Scientist, NGS Assay DevelopmentLocation: Remote (Onsite opportunities available)Science/Focus: Immunological DiseasesJob Overview: Stratacuity is seeking a highly experienced Senior Scientist to lead the development and implementation of advanced NGS assays for our Genomics Innovation team.Key Responsibilities:Develop and refine diverse...
-
Senior Scientist
1 week ago
Watertown, Massachusetts, United States Stratacuity: Proven Scientific Placement Full timeJob Title: Senior Scientist, NGS Assay DevelopmentLocation: Remote (Onsite opportunities available)Science/Focus: Immunological DiseasesJob Overview: Stratacuity is seeking a highly experienced Senior Scientist to lead the development and implementation of advanced NGS assays for our Genomics Innovation team.Key Responsibilities:Develop and refine diverse...
-
Watertown, Massachusetts, United States Stratacuity: Proven Scientific Placement Full timeJob Overview: Stratacuity is seeking a highly skilled NGS Scientist to join our team as a Senior Scientist, NGS Assay Development Specialist. This individual will be responsible for developing and implementing advanced NGS assays for our clients' Genomics Innovation team.Key Responsibilities:Develop and Refine NGS Assays: Lead the development and refinement...
-
Senior Scientist
3 weeks ago
Watertown, Massachusetts, United States Abata Therapeutics Full timeAbout UsAbata Therapeutics is a pioneering biotechnology company dedicated to developing innovative therapies for autoimmune diseases. Our mission is to transform lives by harnessing the power of regulatory T cells (Tregs) to restore homeostasis and enable a robust, durable response.The RoleWe are seeking an experienced and highly motivated Senior/Principal...
-
Senior Environmental Scientist/Project Manager
2 weeks ago
Watertown, Massachusetts, United States VHB Full timeAbout the RoleVHB is seeking a highly skilled Senior Environmental Scientist/Project Manager to join our growing Natural Science team. This position combines field and office work, offering excellent growth opportunities within a dynamic team of professionals.Key ResponsibilitiesLead local, state, and federal wetland permitting applications and assist with...
-
Senior Analytical Development Scientist
3 weeks ago
Watertown, Massachusetts, United States Alkermes Full timeAbout the RoleWe are seeking a highly skilled and experienced Senior Analytical Development Scientist to join our team at Alkermes. As a key member of our Pharmaceutical Development organization, you will provide technical leadership and expertise in analytical development methodologies, driving the successful development of new drugs.Key...
-
Senior Formulation Scientist
1 week ago
Watertown, Massachusetts, United States GQR Full timeJob Title: Associate Scientist, FormulationsJob Summary:We are seeking a highly skilled Associate Scientist to join our Formulation Development team. As a key member of our team, you will be responsible for designing and executing experiments to develop novel formulations for controlled drug delivery.Key Responsibilities:Design and execute experiments to...
-
Senior Formulation Scientist
1 week ago
Watertown, Massachusetts, United States GQR Full timeJob Title: Associate Scientist, FormulationsJob Summary:We are seeking a highly skilled Associate Scientist to join our Formulation Development team. As a key member of our team, you will be responsible for designing and executing experiments to develop novel formulations for controlled drug delivery.Key Responsibilities:Design and execute experiments to...
-
Senior Formulation Scientist
4 weeks ago
Watertown, Massachusetts, United States Alkermes Full timePosition OverviewAs a Senior Scientist specializing in formulation development, you will play a pivotal role in driving technical advancements while designing and conducting laboratory experiments focused on small molecule formulations.Key Responsibilities- Provide expert guidance in the design and execution of laboratory experiments aimed at developing...
-
Principal Scientist
3 weeks ago
Watertown, Massachusetts, United States Abata Therapeutics Full timeAbout UsAbata Therapeutics is a pioneering biotechnology company dedicated to developing innovative therapies for autoimmune diseases. Our mission is to transform lives by harnessing the power of regulatory T cells (Tregs) to restore homeostasis and enable a robust, durable response.The RoleWe are seeking an experienced and highly motivated Senior/Principal...
-
Watertown, Massachusetts, United States Stratacuity: Proven Scientific Placement Full timeJob OverviewWe are seeking a highly skilled NGS Scientist to join our team at Stratacuity: Proven Scientific Placement. As a key member of our Genomics Innovation team, you will be responsible for developing and implementing advanced NGS assays for our clients.Key ResponsibilitiesDevelop and refine diverse NGS assays, staying up-to-date with evolving...
-
Senior Scientist, NGS Assay Development 2043435
1 month ago
Watertown, United States Stratacuity: Proven Scientific Placement Full timeLocation: Watertown MA (Onsite)Science/Focus: Immunological DiseasesJob Overview: This NGS Scientist will have strong genomics experience to develop and implement advanced NGS assays for our clients Genomics Innovation team.Primary Job Responsibilities:Lead in developing and refining diverse NGS assays and keep abreast of evolving sequencing...
-
Senior Scientist, NGS Assay Development 2043435
1 month ago
Watertown, United States Stratacuity: Proven Scientific Placement Full timeLocation: Watertown MA (Onsite)Science/Focus: Immunological DiseasesJob Overview: This NGS Scientist will have strong genomics experience to develop and implement advanced NGS assays for our clients Genomics Innovation team.Primary Job Responsibilities:Lead in developing and refining diverse NGS assays and keep abreast of evolving sequencing...
-
Senior Scientist, NGS Assay Development 2043435
2 weeks ago
watertown, United States Stratacuity: Proven Scientific Placement Full timeLocation: Cambridge MA (Onsite)Science/Focus: Immunological DiseasesJob Overview: This NGS Scientist will have strong genomics experience to develop and implement advanced NGS assays for our clients Genomics Innovation team.Primary Job Responsibilities:Lead in developing and refining diverse NGS assays and keep abreast of evolving sequencing...
-
Senior Scientist, NGS Assay Development 2043435
3 weeks ago
watertown, United States Stratacuity: Proven Scientific Placement Full timeLocation: Watertown MA (Onsite)Science/Focus: Immunological DiseasesJob Overview: This NGS Scientist will have strong genomics experience to develop and implement advanced NGS assays for our clients Genomics Innovation team.Primary Job Responsibilities:Lead in developing and refining diverse NGS assays and keep abreast of evolving sequencing...
-
Senior Scientist, NGS Assay Development 2043435
3 weeks ago
Watertown, United States Stratacuity: Proven Scientific Placement Full timeLocation: Cambridge MA (Onsite)Science/Focus: Immunological DiseasesJob Overview: This NGS Scientist will have strong genomics experience to develop and implement advanced NGS assays for our clients Genomics Innovation team.Primary Job Responsibilities:Lead in developing and refining diverse NGS assays and keep abreast of evolving sequencing...
-
Senior Scientist, Biochemistry
2 weeks ago
Watertown, Massachusetts, United States Treeline Biosciences Full timeAbout Treeline BiosciencesTreeline Biosciences is a pioneering biotechnology company that leverages cutting-edge tools in genomics, lead discovery, medicinal chemistry, and computation to accelerate the development of innovative medicines against challenging targets in cancer and other life-threatening diseases. Our team of experienced biopharmaceutical...
-
Lead Scientist, Analytical Development
3 weeks ago
Watertown, Massachusetts, United States Alkermes Full timeAbout the RoleWe are seeking a highly skilled and experienced Senior Analytical Development Scientist to join our team at Alkermes. As a key member of our Analytical Development team, you will provide technical leadership and expertise in small molecule analytical methodologies, driving the development of new drugs and ensuring their successful...
-
watertown, United States Scion Life Sciences Full timeScion Innovation, A Scion Life Sciences CompanyAbout Us:Scion Innovations, located in Watertown, Massachusetts, is discovering and developing innovative biologics and other large molecules for various diseases and disorders of considerable unmet need. The company is dedicated to creating proprietary therapeutics and intellectual property that will be spun...
-
Watertown, United States Scion Life Sciences Full timeScion Innovation, A Scion Life Sciences CompanyAbout Us:Scion Innovations, located in Watertown, Massachusetts, is discovering and developing innovative biologics and other large molecules for various diseases and disorders of considerable unmet need. The company is dedicated to creating proprietary therapeutics and intellectual property that will be spun...
Senior Bioinformatics Scientist
4 months ago
Acrivon is a clinical stage biopharmaceutical company developing precision oncology medicines that it matches to patients whose tumors are predicted to be sensitive to each specific medicine by utilizing Acrivon’s proprietary proteomics-based patient responder identification platform, Acrivon Predictive Precision Proteomics, or AP3. The AP3 platform is engineered to measure compound-specific effects on the entire tumor cell protein signaling network and drug-induced resistance mechanisms in an unbiased manner. These distinctive capabilities enable AP3’s direct application for drug design optimization for monotherapy activity, the identification of rational drug combinations, and the creation of drug-specific proprietary OncoSignature companion diagnostics that are used to identify the patients most likely to benefit from Acrivon’s drug candidates.
Acrivon is currently advancing its lead candidate, ACR-368 (also known as prexasertib), a selective small molecule inhibitor targeting CHK1 and CHK2 in a potentially registrational Phase 2 trial across multiple tumor types. The company has received Fast Track designation from the Food and Drug Administration, or FDA, for the investigation of ACR-368 as monotherapy based on OncoSignature-predicted sensitivity in patients with platinum-resistant ovarian or endometrial cancer. Acrivon’s ACR-368 OncoSignature test, which has not yet obtained regulatory approval, has been extensively evaluated in preclinical studies, including in two separate, blinded, prospectively-designed studies on pretreatment tumor biopsies collected from past third-party Phase 2 trials in patients with ovarian cancer treated with ACR-368. The FDA has granted Breakthrough Device designation for the ACR-368 OncoSignature assay for the identification of ovarian cancer patients who may benefit from ACR-368 treatment. In addition to ACR-368, Acrivon is also leveraging its proprietary AP3 precision medicine platform for developing its co-crystallography-driven, internally-discovered preclinical stage pipeline programs. These include ACR-2316, a potent, selective WEE1/PKMYT1 inhibitor designed for superior single-agent activity as demonstrated in preclinical studies against benchmark inhibitors, and a cell cycle program with an undisclosed target.
Our global team operates out of two leading life science clusters, Watertown, MA and Medicon Village in Lund, Sweden.
Position Overview:
The Senior Bioinformatics Scientist will be a key member of Acrivon Therapeutics’ Data Science Team and will leverage their bioinformatics and computational biology expertise to provide innovative solutions for our drug discovery and development efforts, leveraging Acrivon’s AP3 platform. The ideal candidate will possess hands-on experience in developing, implementing, and deploying data analytics tools and models, with a particular emphasis on AI/ML algorithms. Additionally, the candidate will have a track record integrating multi-omics datasets to generate actionable biological insights, including the identification and validation of targets, elucidation of mechanisms of action, and discovery of biomarkers. This position will be based in Watertown, MA.
Duties and Responsibilities:
- Contribute to evaluation and fine-tuning of AI foundation models by leveraging AP3 and multi-omics data.
- Extract and curate external multi-omics data, enabling integration with AI/ML methodologies.
- Contribute to the advancement of innovative computational methods for analyzing large-scale proteomics and phosphoproteomics datasets.
- Provide customized computational analyses in collaboration with proteomics, biology, and biomarker development teams.
- Design and maintain interactive web-based applications that integrate internal and external data within a cloud environment.
- Use data mining, text mining, network visualization and AI/ML techniques to identify potential biomarkers.
Requirements and Qualifications:
- Demonstrated proficiency of 2-6 years in applying bioinformatics or computational biology methodologies preferably within an industry environment, with a preference for experience in oncology and immunology.
- Hands on experience in the development and implementation of AI/ML methodologies, including deep learning, large language models (LLMs), or protein language models (pLMs).
- Hands on experience in developing computational workflows and conducting data analyses for multi-omics datasets, with a particular emphasis on proteomics/phosphoproteomics.
Qualifications include:
- Ph.D. or M.S. in Computational biology, Bioinformatics, Engineering, Computer Sciences, or a related field.
- Proficient coding skills, especially in Python and R, alongside proficiency in other scripting languages.
- Experience with machine learning frameworks such as TensorFlow, PyTorch, or scikit-learn.
- Hands-on experience in constructing and deploying web-based applications utilizing web development frameworks, such as R Shiny, Python Django/Flask/Streamlit.
- Familiarity with cloud computing platforms such as AWS, Google Cloud, or Azure.
- Familiarity with cancer biology in a drug discovery and development setting is preferred.
- Excellent communication and presentation skills with demonstrated record of peer-reviewed publication.
- Team player with ability to nurture productive collaborative relationship with internal and external partner.
Acrivon Therapeutics is proud to be an equal opportunity employer and to provide equal opportunities to all employees and applicants for employment without regard to race, color, religion, sex or gender identity, national origin, age, disability, sexual orientation or genetics. In addition to federal law requirements, Acrivon Therapeutics complies with applicable state and local laws governing nondiscrimination in employment.
