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Senior Scientist

4 months ago

San Antonio, United States Scorpius Biomanufacturing Full time
Job DescriptionJob Description

The Company

Scorpius BioManufacturing is a boutique biologics CDMO providing cGMP manufacturing, bioanalytical, and process development services for protein modalities. Our facility in San Antonio, Texas specializes in working with start-ups, emerging biotechs, and academic researchers. Scorpius was founded by a serial biotech entrepreneur determined to make small-volume programs a big priority. Clients benefit from decades of expertise taking large molecule drugs to market and can rely on Scorpius to offer Quality, Speed, Flexibility, & Responsiveness.

Position Summary

This person will provide scientific expertise and leadership for the Scorpion Biological Services Biomanufacturing Process Development group. This entails independently performing and/or managing day-to-day process development activities in conjunction with team members, project leaders, and customers to enable cGMP production of pre-clinical and clinical-grade biologics, including therapeutic proteins, cell-based therapies, and plasmid and viral vectors at Scorpius BioManufacturing. This person will have strict attention to detail and exceptional customer service skills.

Key Responsibilities

  • Assist in the development and optimization of upstream biologics (mammalian and bacterial)/cell therapy production processes that follow FDA and/or appropriate global regulations and guidelines.
  • Lead technology transfer from external client teams. Responsible for collaborating with Manufacturing Sciences and cGMP operations group to modify existing manufacturing processes and developing them for clinical-scale, cGMP-compliant manufacturing. This includes transfer of processes into the cleanroom environment, process troubleshooting and, in collaboration with the Biomanufacturing Operations team, generation of all relevant cGMP documentation (Batch Records, Compounding Records, Operating Procedures, etc.).
  • Collaborate with Facilities staff in maintaining the calibration, preventative maintenance and validation strategy for all Process Development equipment. This includes the development and implementation of operation and maintenance protocols for equipment and the execution and documentation of equipment validations as necessary.
  • Assist in preparing CMC documents related to Process Development projects.
  • Support Quality Assurance group by assisting in employee training, document control, validation support, calibration and preventative maintenance support, change control deviation reporting, CAPA, risk analysis, etc.
  • Manage relationships with outside contractors including equipment and consumable vendors, calibration and service contracts and validation firms.


Education and Experience

  • Requires a BS, MS or PhD degree from an accredited college or university with major course work in a Scientific or Engineering discipline.
  • Requires 10+ years (BS), 8+ years (MS) or 5+ years (PhD) of Biologics process development experience.
  • Strong working knowledge of cGMP principles and Quality Management Systems.
  • Experience working in a cGMP clinical and/or commercial-scale manufacturing environment is highly desirable.

Knowledge & Skills

  • Expert in both upstream and downstream biomanufacturing processes is preferred.
  • Experience with day-to-day biologics laboratory techniques.
  • Knowledge of manufacturing processes in both mammalian and microbial systems is desirable, such as:
    1. Aseptic processing
    2. Cell therapy: stem/progenitor cells, iPSC differentiation, vaccines, exosomes
    3. Protein therapeutics: mAbs, bispecific proteins, therapeutic enzymes, vaccines
    4. Microbial fermentation – scale-up
    5. Mammalian cell culture: suspension & adherent – scale-up
    6. Product recovery: filtration, centrifugation, microfiltration, etc.
    7. Protein purification: UF/DF, ion exchange, Protein A/G, HTP, HIC
    8. Product formulation / stabilization
  • Experience in biologics analytical characterization is highly desirable.
  • Analytical ability, both interpersonal and issue-related; good judgment and ethics; professional presence and demeanor.
  • Ability to continuously learn new techniques and skills and apply them to personal career growth.
  • Outstanding interpersonal skills: ability to build strong relationships with cross-functional team members and lead through influence.
  • Must maintain a working knowledge of phase-appropriate cGMPs as they apply to various phases of product clinical development.
  • Must obtain a working knowledge of current global regulatory requirements and guidelines and perform within all Scorpius Standard Operating Procedures (SOPs) and policies.
  • Ability to take responsibility and “get the job done” in a high-energy, high-intensity, results-oriented environment.
  • Excellent verbal and written communication skills; strong presentation skills as this role requires the ability to communicate and connect with all levels of the organization.
  • Must possess good to excellent writing and PC skills with a knowledge base in Microsoft Word, Excel, Power Point, and Project.
  • Working knowledge of Engineering software applications (Visio, SuperPro Designer, Matlab, Minitab, etc.) highly desirable.

Physical Requirements and Working Environment

  • Flexibility is required for working hours. Some weekend work may be needed and earlier or later start/finish times may also be required.
  • The essential functions of the job are usually performed in an environmentally controlled facility where the noise level in the work environment is usually moderate. This position may involve a combination of office and laboratory environments and automated equipment.
  • While performing the job duties, the employee is regularly required to sit; reach with hands and arms and talk or hear. The employee is frequently required to stand and walk. The employee may sometimes be required to lift and/or move up to 20 pounds. Specific vision abilities required by this job include close vision, distance vision, color vision and ability to adjust focus. The employee must have the manual dexterity and manual ability to effectively use computer terminals.