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Sr. Scientist, Assay Development
2 months ago
- Plan, perform, and optimize antibody conjugations, fragmentations, and purifications
- Independently design, create, and troubleshoot recombinant protein-bead constructs
- Develop insights into interaction of company technology with biological variables, leading to enhanced detection and quantification of biomarkers.
- Find creative and practical solutions to a wide range of cross-disciplinary technical challenges.
- Use analytical and statistical techniques to characterize experimental results.
- Effectively troubleshoot workflows and experiments on a proactive basis, taking ownership of results, interpretations, scope, strategy, and tactics on a project level.
- Maintain a clear and complete log of research results in electronic form, following quality systems requirements; organize experiments and findings into databases.
- Effectively communicate experimental findings in written and verbal formats during internal meetings.
- Partner effectively with other members of the Assay Development team as well as all other departments in support of company objectives.
- Ensure laboratory activities are performed in compliance with safety guidelines and best practices.
- Serve as mentor for other scientists/engineers and research associates in areas of expertise; may be responsible for direct reports.
- Builds consensus and gains support of key stakeholders. Coordinates across and within the organization to determine the appropriate resources and parameters to complete projects in the most efficient manner. Is a driver of change and decision-making within the department; contributions are essential to the department and company's objectives. Ensures a high degree of quality in the department's work.
- Demonstrates group-wide influence and scientific/technical competence, in addition to having a strong business-sense as it relates to the needs and requirements at Xzom.
- Exercises independent judgment in creating and innovating methods, techniques and evaluation criteria for obtaining results. Demonstrates ability to discover and identify processes, novel science and technology, which leads to increased productivity and results.
- May provide task/project leadership, guidance and mentoring of others while being equitable and respectful to everyone. Responsible for compliance with all company policies outlined in the Employee Handbook.
- Responsible for compliance with quality procedures and all regulatory requirements.
- Consistently exhibits respect and build trust through openness, collaboration, and support of one another.
- Operates with respect, humbleness, integrity, honesty, and transparency.
- Demonstrates inclusivity, ongoing communication, and a positive outlook with both internal and external team members and customers.
- Typically requires a minimum of 12 years of related experience and a Bachelor's and/or a minimum of 8 years and a Master's degree, and/or PhD in a scientific discipline with at least 5 years of post-PhD experience; or equivalent combination of education and experience.
- Solid experience in and knowledge of antibody fundamentals and pairing, including antibody fragmentation, conjugation, and purification is required.
- Working knowledge of buffers and protein solubility
- Solid working experience in a wide variety of protein purification, detection, and identification techniques (e.g.ELISAs, Western Blots, chromatography, immunoprecipitation, immunocytochemistry, enzyme assays).
- Understanding of protein interactions, antigen-antibody interaction kinetics
- Experience in IVD assay development is a plus.
- Expertise in the design and development of biochemical and immunoassays is required.
- Understanding of experimental design – selection of appropriate controls, variables, and conditions is required
- Self-motivated with superior organization and observation skills.
- Innovative in developing new assays or approaches to meet desired goals
- Ability to identify and resolve technical challenges
- Expertise in the application of statistical analysis and software (e.g., GraphPad Prism) to drive decision making.
- Ability to communicate research results in a clear and concise fashion.
- Ability to work in a team-based setting.
- Desire and drive to work in a fast-paced, hands-on environment.
