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Research Scientist, Nucleic Acid Chemist
3 months ago
About GenScript
GenScript Biotech Corporation (Stock Code: 1548.HK) is a global biotechnology group. Founded in 2002, GenScript has an established global presence across North America, Europe, the Greater China, and Asia Pacific. GenScript's businesses encompass four major categories based on its leading gene synthesis technology, including operation as a Life Science CRO, enzyme and synthetic biology products, biologics development and manufacturing, and cell therapy.
GenScript is committed to striving towards its vision of being the most reliable biotech company in the world to make humans and nature healthier through biotechnology
About ProBio
ProBio proactively provides end-to-end CDMO service from drug discovery to commercialization with proactive strategies, professional solutions and efficient processes in cell and gene therapy (CGT), vaccine, biologics discovery and antibody protein drug to accelerate drug development for customers. ProBio's total cell and gene therapy solution covers CMC of plasmid and virus for IND filing as well as clinical manufacturing and commercial manufacturing. In terms of plasmid service, ProBio supports the most clinical approvals for CGT drugs including mRNA vaccines, CAR-T in China. It is also the first GMP manufacturing platform to provide in vitro transcription (IVT) template linearized plasmids for mRNA vaccines and has supported several mRNA vaccine global enterprises to obtain clinical approvals. In terms of viral vector service, \ProBio has a stable and high-yield viral vector platform.
Job Scope:
We are seeking an experienced Scientist with a multi-disciplinary background, specifically in the areas of oligonucleotide synthesis, surface functionalization, organic/bioorganic synthesis, and molecular biology. Successful candidates may also have knowledge and experience with biosensors, electrochemistry and nucleic acid chemistry. This position will involve research and collaboration with scientists and engineers improving the company's proprietary semiconductor DNA synthesis technology and developing various diagnostic applications.
Location: Redmond, WA
Responsibilities:
- Develop surface functionalizations for metal and non-metal surfaces for solid phase oligonucleotide synthesis
- Select and employ analytical techniques for surface characterization
- Explore methods toward enhancing surface stability and functional loading
- Develop characterization methodologies to analyze electrochemically synthesized oligonucleotide microarrays and pools
- Contribute knowledge and expertise in the field of nucleic acid chemistry, specifically phosphoramidite based oligonucleotide synthesis.
- Contribute to the development and optimization of electrochemical detritylation techniques.
- Contribute to the optimization of all aspects of CustomArray's array based oligonucleotide synthesis platform
- Develop electrochemical detection assays over oligonucleotide microarray
- Technology transfer to the production team and support as needed for process improvement or troubleshooting
- Perform statistical data analysis and present the results
Qualifications
- D. in Chemistry, Materials, Surface science, Biochemistry, Bioengineering, or related biomedical field with a minimum of 4 year experience in pharmaceutical companies, biotech or related industries
- Industrial track record of success in product or assay development
- Knowledgeable in electrochemistry and experience with electrochemical detection is preferred
- Experience with nucleoside, nucleotide, and solid-phase oligonucleotide synthesis
- Experience with surface chemistry
#LI-SL3
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GenScript USA Inc/ProBio Inc. is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is the Company's policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law.
GenScript USA Inc./ProBio Inc. maintains a drug-free workplace.
