Senior Scientist or Principal Scientist
1 month ago
Specific responsibilities include, but are not limited to:
- Cell engineering of primary T cells, iPSC and iPSC-derived T cells using various gene delivery methods, including but not limited to CRISPR KO/KI, lentivirus/gamma retrovirus transduction.
- Support the therapeutic development of T cell products derived from iPSCs.
- Design and execute experimental plans for the development and optimization of the hypoimmune iPSC platform.
- Process development of iPSC multiplex editing and single cell cloning process. Establish in-house control laboratory operation to manufacture genetically modified iPSC seed stock for pipeline.
- Write SOP, technical reports, and develop appropriate documentation for processes.
- Analyze, interpret, and effectively present data at team meetings
Requirements and Experiences
- A minimum of 2 years postgraduate experience in relevant roles in academia/industry, preferably in allogeneic cell therapy space
- Strong hands-on experience with iPSC culture, gene editing and single cell cloning.
- Knowledge of GxPs, past experience in process development or GMP operation is a plus.
- Strong organizational skills and an ability to prioritize effectively to deliver results within established timelines.
- Strong verbal and written communication skills are critical in the fast-face and collaborative working environment.
- Demonstrated accountability and flexibility to change project objectives quickly and enthusiastically.
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