Research Associate/Senior Research Associate, Formulation Discovery
2 months ago
Verve is a clinical-stage genetic medicines company established with a mission to solve the global health epidemic of cardiovascular disease. Founded by world-leading experts in cardiovascular medicine, human genetics and gene-editing, Verve is pioneering a new approach to the care of cardiovascular disease, potentially transforming treatment from chronic management to single-course gene editing medicines. The company's initial three programs – VERVE-101, VERVE-102, and VERVE-201 – target genes that have been extensively validated as targets for lowering low-density lipoprotein cholesterol (LDL-C), a root cause of cardiovascular disease. VERVE-101 and VERVE-102 are designed to permanently turn off the PCSK9 gene in the liver and are being developed initially for heterozygous familial hypercholesterolemia (HeFH) and ultimately to treat atherosclerotic cardiovascular disease (ASCVD) patients not at goal on oral therapy. VERVE-201 is designed to permanently turn off the ANGPTL3 gene in the liver and is initially being developed for homozygous familial hypercholesterolemia (HoFH) and ultimately to treat patients with refractory hypercholesterolemia. In 2023, Verve was named a Top Place to Work by The Boston Globe for the third consecutive year. Verve is headquartered in Boston, Massachusetts.
The PositionWe are seeking a motivated Research Associate or Senior Research Associate to join our Formulation Discovery team. The successful candidate will have a background in the preparation and characterization of nanoparticle-based delivery systems for nucleic acid therapeutics. In addition, the candidate will have to work in a multidisciplinary fast-paced team environment.
Job Responsibilities- Design and preparation of lipid nanoparticles (LNPs) for early-stage evaluation of delivery of nucleic acid payloads in cell-based and preclinical animal models.
- Characterization of LNPs through HPLC, spectroscopic techniques such as UV-Vis and fluorescence, ribogreen assays and pKA.
- After successful screening and identification of lead LNP formulations, the candidate will have the opportunity to further streamline and advance the formulation towards clinical development.
- Design, preparation, and characterization of lipid nanoparticles for screening efficient delivery of nucleic acid payloads in preclinical animal models.
- Prepare technical reports and presentations pertaining to formulation development.
- Generate/write protocols, and SOPs.
- Cross-functional collaboration.
- Other duties as assigned.
- Research Associate
- S. degree in chemical engineering, bioengineering, chemistry, pharmaceutical sciences, or another related field.
- Senior Research Associate
- S. degree in chemical engineering, bioengineering, chemistry, pharmaceutical sciences, or another related field.
- 3+ years of relevant industry experience
- Experience with nanomedicinal formulations preferred.
- Strong problem-solving skills, and creative/innovative approach in problem solving.
- Ability to work independently and in very dynamic interdisciplinary team environments.
- Proven records in working with partners/collaborators is desirable.
- Organized, detail-oriented, and innovative self-starter who continuously seeks to improve existing laboratory methods and processes.
- Effective verbal and written communication skills; proficiency in literature search and relevant computer software skills are required.
Don't check off every box in the requirements listed above? Please consider applying anyway. We want the best candidates for the job, and those candidates don't always meet 100% of the qualifications listed. At Verve, we are dedicated to building diverse and inclusive teams who embody the values we share: grit, spirit, drive, and passion. We look forward to learning more about your unique background.
EEO StatementVerve Therapeutics is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. If you have a disability or special need that requires accommodation, please let us know.
Recruitment & Staffing AgenciesVerve Therapeutics does not accept agency resumes unless contacted directly by internal Verve Talent Acquisition. Please do not forward resumes to Verve employees or any other company location; Verve Therapeutics is not responsible for any fees related to unsolicited resumes.
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