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Automation Scientist

3 months ago

San Diego, United States Integrated Resources, Inc ( IRI ) Full time

Job Title: Automation Scientist

Location: San Diego, CA

Duration: 12 months+


Job Summary:

Actively seeking a highly skilled automation specialist with a strong background in liquid handling robotics and integration with supporting instrumentation. The ideal candidate will demonstrate innovative approaches when designing, optimizing, and implementing Next-Generation Sequencing (NGS) or cell- and organoid-based workflows on automated robotic systems. As part of this role, the candidate will cultivate a growth mindset and develop expertise in emerging automation technologies. The candidate will also conduct experiments, including scale-down, high-throughput, and automation, to enhance our team’s screening capabilities in patient-derived organoid model systems for early drug target discovery. This role offers a unique opportunity for the successful candidate to collaborate with diverse cross-functional scientific teams and contribute to groundbreaking drug discoveries that directly impact patient health.


Responsibilities:

  • Integrate Liquid Handling Robotics: Seamlessly incorporate liquid handling robotics (such as Beckman-Coulter Biomek i7 & Dynamic Devices Lynx) with supporting instrumentation to execute molecular and cellular biology and organoid workflows.
  • Automate Standardized Assays: Validate and deploy automated workflows for various standardized assays, including DNA/RNA purification, NGS library preparation, qPCR, cell and organoid passaging, cell/organoid media changes, cell-based viability assays, high-content cell imaging, and sample normalization.
  • Collaborate and Translate Benchtop Processes: Work closely with scientists to translate benchtop processes into fully automated workflows. This involves programming/scripting stepwise protocols and rigorously validating processes through dry and wet runs.
  • Design User-Friendly Processes: Develop and validate end-to-end processes on integrated lab automation platforms, prioritizing user-friendly design, robust execution, and secure data management.
  • Troubleshoot and Enhance Efficiency: Perform advanced experimental troubleshooting alongside scientists to improve ease-of-use, process efficiency, and scientific integrity.
  • Cross-Functional Collaboration: Collaborate with cross-functional teams to integrate NGS and organoid workflows into automated liquid handling systems, ensuring project success.
  • Technical Troubleshooting: Address technical and instrument issues related to automation, NGS, and cell-based workflows.
  • User Training: Train end-users in automated platform usage (Beckman-Coulter Biomek i7, Dynamic Devices Lynx, Analytik Jena CyBio FeliX) and workflow execution.
  • Stay Current with Technology: Keep up to date with advancements in automation technology and emerging methodologies applicable to liquid handling systems.
  • Independent Workflow Development: Work independently on Client automated workflows.
  • Meticulous Record Keeping: Generate, organize, and maintain meticulous records of all conducted experiments.
  • Collaboration and Organization: Collaborate with multiple teams across the organization, supporting and sharing methodologies while aligning efforts and harmonizing experimentation.
  • Lab and Equipment Management: Manage lab and equipment organization and maintenance


Qualifications, Skills/Knowledge preferred

  • Master’s degree with 1+ year or Bachelor’s degree with 3+ years’ experience in bioengineering or biology with a strong focus on automation platforms & liquid handlers in pharmaceutical, biotechnology companies, or academic/not-for-profit organizations
  • Minimum 3 years of hands-on experience programming and troubleshooting liquid handling platforms for high-throughput screening (HTS), as well as NGS- and organoid- or cell-based workflows
  • Direct experience with laboratory operations and maintenance of common automation instruments used for NGS workflows
  • Strong understanding of molecular and cellular biology, including NGS assays (e.g., DNA-seq, RNA-Seq). Demonstrated utilization of these assays in practical settings.
  • Proven ability to create, follow, and maintain Installation Qualifications (IQ), Operational Qualifications (OQ), Performance Qualifications (PQ) protocols as well as Standard Operating Procedures (SOPs) for lab automation systems
  • Successfully worked with R&D teams to deliver automation projects
  • Effective communication and collaboration skills within a multidisciplinary team environment
  • Functional knowledge of at least one high-level programming language (e.g., Python). Additional knowledge in other programming languages (e.g., Perl, R, C++) is a plus
  • Experience programming, executing, and troubleshooting workflows using Beckman-Coulter and/or Dynamic Devices liquid handling platforms
  • Proficient at organizing multiple concurrent projects and tasks.
  • Excellent troubleshooting and problem-solving skills
  • Rigorous and constant evaluation of own work to maintain high quality


Preferred Skills:

  • Extensive hands-on experience with high-throughput methods, liquid handlers, and laboratory automation schedulers
  • Proficiency in integrating liquid handling systems with supporting instrumentation
  • In-depth expertise of end-to-end NGS workflows, with a focus on instrumentation and automation
  • Functional understanding of cellular biology, molecular biology, DNA/RNA purification
  • Proficiency in Next-Generation Sequencing (NGS) protocols
  • Knowledge of automation programming and/or scripting (e.g., Python) for liquid handlers
  • Previous experience in manual or automated organoid culture and assay development, is a plus


Additional Job Requirements:

Lab w/ blood & animal

Position Handles Hazardous Materials