Scientist

2 months ago

Danbury, United States Patel Consultants Corporation Full time

Our client is in need of a chemist skilled in Solid State NMR spectroscopy.


Duties & Responsibilities:

  • Apply skill in solid-state NMR (ssNMR) spectroscopy to acquire and interpret (1D and 2D 1H, 19F, 13C, 15N, etc.) data for molecular structure elucidation.
  • Apply ssNMR to characterize pharmaceutical materials such as particles, powders, and suspensions and to guide robust drug substance and drug product development.
  • Use NMR expertise to evaluate and characterize a broad range of materials, including crystalline and non-crystalline small molecule APIs, biologics, excipients, drug product intermediates, and drug products.
  • Apply quantitative ssNMR methods to measure components of APIs and drug products.
  • Use molecular modeling and predictive tools with technologies such as solution/solid state NMR and X-ray crystallography to enable 3D structural evaluation at the atomic and molecular level.
  • Ensure back-up and retrieval of all ssNMR data.
  • Plan and perform experiments with minimal supervision to provide investigative support of structural predictions.
  • Remain current with relevant scientific literature and apply knowledge to the design, modification and implementation of new experiments.
  • Write protocols, methods and technical reports; provide scientific interpretation of results with minimal guidance.
  • Present at internal scientific meetings.


Requirements:

  • Background in use of solution NMR for structure elucidation is highly desired.
  • Experience with solid-state NMR sample preparation, data acquisition and interpretation of multinuclear NMR data is required.
  • Experience with implementing and trouble-shooting ssNMR experiments.
  • Experience changing Bruker ssNMR probes is required.
  • Basic understanding of molecular structure, inter-atomic distances, hydrogen bonding, torsion angle strain, hydrophobic and hydrophilic interactions.
  • Experience in the application and interpretation of ssNMR to study biological systems is a plus.
  • Understands the conceptual basis behind modern computational methods such as qm-DFT, Monte Carlo methods, etc.
  • Knowledgeable in the routine use of molecular modeling software (example: Gaussian, Schrodinger, Materials Studio suite, CCDC software )
  • Familiar with use of HPC clusters, Linux environment and associated job submission programs.
  • Experience collaborating with diverse teams and demonstrated ability to work independently and with minimal supervision.
  • Experience with preparing and analyzing membrane protein samples is a plus.
  • Excellent laboratory practices to ensure safety and sample integrity.
  • Excellent oral and written communication skills, highly organized and efficient record keeping.
  • Background in use of solution NMR for structure elucidation is desired.

Master's Degree in Organic Chemistry or equivalent with 1-3 yrs. experience in the application of ssNMR Spectroscopy to structurally characterize pharmaceutically relevant small molecules.


  • SPECTROSCOPY
  • NMR
  • ANALYTICAL INSTRUMENTATION
  • ANALYTICAL CHEMISTRY

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