Principal Scientist Antibody Development

2 months ago


Boston, United States Scienta Full time

Job Title: Principal Scientist - Antibody Development

Location: Boston, MA


I'm working with a pre-clinical biotechnology company revolutionizing the field of antibody discovery through the integration of cutting-edge machine learning (ML) platforms.


Job Description: As a Principal Scientist, Antibody Development, you will play a pivotal role in driving our antibody discovery programs from conception through to preclinical development. Leveraging our proprietary ML platform, you will lead the design, optimization, and characterization of antibodies with the potential to address unmet medical needs.


Key Responsibilities:

  • Lead antibody discovery projects from target identification to lead selection.
  • Oversee generation, screening, and validation of antibody candidates using in vitro and in vivo assays
  • Apply deep knowledge of antibody engineering, including humanization, affinity maturation, and stability optimization.
  • Design and interpret experiments to evaluate antibody binding, specificity, and functional activity.
  • Manage cross-functional teams and drive project milestones.
  • Apply knowledge of antibody engineering for optimization.


Qualifications:

  • Ph.D. in Immunology, Molecular Biology, Biochemistry, or a related field.
  • 8+ years of experience in antibody discovery and development, with a proven track record of advancing candidates to preclinical or clinical stages.
  • Strong expertise in antibody engineering, including experience with display technologies (e.g., phage, yeast).
  • Proficiency in using ML and computational tools for antibody design and optimization.
  • Demonstrated ability to lead multidisciplinary teams and manage complex projects.
  • Excellent problem-solving skills, with a strong analytical and data-driven approach.
  • Effective communication and presentation skills, with the ability to convey complex scientific concepts to diverse audiences.



  • Boston, United States Scienta Full time

    Job Title: Principal Scientist - Antibody DevelopmentLocation: Boston, MAI'm working with a pre-clinical biotechnology company revolutionizing the field of antibody discovery through the integration of cutting-edge machine learning (ML) platforms.Job Description: As a Principal Scientist, Antibody Development, you will play a pivotal role in driving our...


  • Boston, United States Eli Lilly and Company Full time

    At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities...


  • Boston, United States Eli Lilly and Company Full time

    At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities...


  • Boston, United States Lilly Full time

    At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities...


  • Boston, United States Eli Lilly and Company Full time

    At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities...


  • Boston, United States Eli Lilly and Company Full time

    At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities...


  • Boston, United States Eli Lilly and Company Full time

    At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities...


  • Boston, United States Eli Lilly and Company Full time

    At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities...


  • Boston, United States Ensoma Full time

    Open positions Location: Boston, MAJob Id: R096–R2# of Openings: 1We seek an energetic and motivated Principal Scientist or Associate Director to lead the design and execution of strategies to engineer hematopoietic stem cells by a combination of genetic and protein engineering approaches.You will join a team of scientists dedicated to moving a novel gene...


  • Boston, United States Ensoma Full time

    Open positions Location: Boston, MAJob Id: R096–R2# of Openings: 1We seek an energetic and motivated Principal Scientist or Associate Director to lead the design and execution of strategies to engineer hematopoietic stem cells by a combination of genetic and protein engineering approaches.You will join a team of scientists dedicated to moving a novel gene...


  • Boston, United States Ensoma Full time

    Open positionsLocation: Boston, MAJob Id: R096-R2# of Openings: 1We seek an energetic and motivated Principal Scientist or Associate Director to lead the design and execution of strategies to engineer hematopoietic stem cells by a combination of genetic and protein engineering approaches.You will join a team of scientists dedicated to moving a novel gene...


  • Boston, United States Ensoma Full time

    Open positions Location: Boston, MA Job Id: R096–R2 # of Openings: 1 We seek an energetic and motivated Principal Scientist or Associate Director to lead the design and execution of strategies to engineer hematopoietic stem cells by a combination of genetic and protein engineering approaches. You will join a team of scientists dedicated to moving a novel...


  • Boston, United States Nona Biosciences Full time

    Job DescriptionResponsibility:Design and engineer antibodies for various applications.Produce and purify antibodies using different mammalian expression systems (CHO, HEK293, etc.).Perform detailed antibody characterization using techniques such as HPLC, FPLC, and OCTET.High-throughput antibody production and screening.Analyze data and interpret results to...


  • Boston, Massachusetts, United States Merck Full time

    Job DescriptionOur Scientists are our Inventors. We deliver robust scientific data and interpretation that drives the commercialization of breakthrough therapeutics using innovative thinking, state-of-the-art facilities and modern equipment. Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of people like...

  • Principal Scientist

    1 month ago


    Boston, Massachusetts, United States GALY Full time

    Principal Scientist / Distinguished Scientist, Cell Biology (Cotton Fiber Development) We are out of time. Change must be immediate. We have to help the world find alternative ways to produce all the same things we love. But better. Using less land, less water, less energy, and making less waste. If you think that sounds like a mission, well, you are right....


  • Boston, United States Elektrofi Full time

    Our breakthrough ultra-high concentration microparticle technology platform resolves the limitations associated with intravenously biologic therapies by enabling convenient at-home subcutaneous self-administration.Elektrofi is looking for a Translational Scientist/ Senior Scientist to support the development of the novel Elektrofi formulation platform.The...


  • Boston, Massachusetts, United States Elektrofi Full time

    Our breakthrough ultra-high concentration microparticle technology platform resolves the limitations associated with intravenously biologic therapies by enabling convenient at-home subcutaneous self-administration.Elektrofi is looking for a Translational Scientist/ Senior Scientist to support the development of the novel Elektrofi formulation platform.The...


  • Boston, United States Flagship Pioneering Full time

    Company Summary: Ampersand Biomedicines is an innovative, privately held biotechnology company leading the way in developing multi-specific medicines that direct a wide range of therapeutic molecules to specific cells and biological contexts (www.Ampersand.bio). Ampersand was founded in Flagship Pioneering’s venture creation engine, where companies such as...


  • Boston, United States Takeda Full time

    Job DescriptionAbout the role:At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients...


  • Boston, United States Aktis Oncology Inc Full time

    Job DescriptionJob DescriptionAktis Oncology is a biotechnology company pioneering the discovery and development of a new class of targeted alpha radiopharmaceuticals to treat a broad range of solid tumor cancers. Founded and incubated by MPM Capital, the company has developed proprietary platforms to generate tumor targeting agents with ideal properties for...