Principal Scientist, Oncology Research
4 months ago
The Principal Scientist within the Oncology Research group will work in cross-functional teams to identify and develop novel therapies to treat targeted patient populations within multiple oncology indications. She/he will independently apply and develop cutting edge tools and methodologies to enable advancement of company objectives with a focus on early discovery and lead optimization activities. Through project leadership and experimental activities, the team member will find solutions to program related challenges in order to advance programs as part of the of the Oncology Research Team.
BACKGROUND/TRAINING
- Ph.D. in biological sciences or related field, preferably related to oncology or cancer biology
- 2-8 years of biopharmaceutical research experience in drug discovery and/or translational research
EXPERIENCE/ACCOMPLISHMENTS
- Experience with the application and development of basic science methodologies to develop complex strategies and enable the advancement of Company objectives.
- Demonstrated success with the execution and interpretation of in vitro, ex-vivo and in vivo experiments to explore therapeutic potential of drug targets and drive development programs.
- Experience leading target identification, validation and drug discovery biology efforts to enable nomination of drug candidates for clinical development.
- Strong technical background in planning, designing and executing pre-clinical in vitro and in vivo (required) experiments in order to evaluate target biology and characterize the efficacy and safety of development candidates in relevant oncology models
- Required expertise includes:
- Imaging, microscopy and/or pathology experience that can be leveraged to examine target expression across cell lines and/or tissue section
- Mammalian cell culture/cell line engineering
- Flow cytometry
- Common molecular and biochemical techniques (DNA/RNA isolation, qPCR, Western, ELISA, antibody characterization and QC, etc.)
- Preferred expertise includes:
- Knowledge of cell-based assays and in vitro pharmacology
- Experience with biophysical characterization of targets
- Subcellular / tissue localization
- Target:ligand interactions
- Target density evaluation
- Mechanism of action studies
- Target engagement assay development
- In vivo tumor modelling; PK/PD/Efficacy relationships
- Required expertise includes:
- Demonstrated success in the area of target discovery, target evaluation or drug discovery, translational research and integration with matrixed project teams
- Demonstrated ability to gather relevant information systematically, break down problems into simple components and make sound decisions
- Willingness to take on new challenges and build a culture of rigor and data-driven decision making to bring novel therapies to the clinic
- Effectively communicates and collaborates with other R&D team members and collaborators to progress development candidate compounds
- Demonstrated high standards for scientific rigor, team behaviors, excellence and building a culture of innovation that is fully aligned with company objectives
- Demonstrated tenacity and drive for enterprise benefit
- Excellent interpersonal and collaborative skills.
- Thrives in a fast-paced, ever-changing growth environment with the ability to work independently
- Proven demonstration of transparent communication and fostering open and diverse debate.
- Ability to work with agility and manage ambiguity
- Personifies positive energy and exemplifies respect
Please refrain from contacting Aktis team members directly. Only online applications will be reviewed by our Talent Acquisition team.
-
Boston, United States Pyxis Oncology Full timePosition: Principal Scientist, Translational Bioinformatics Hiring Manager: Head of Translational Medicine Location: Local to Boston, MA or Remote US Travel: [If Remote] Up to 20% of domestic travel Position Summary: Pyxis Oncology (‘PYXS’ or ‘Company’) is seeking an innovative, methodical and collaborative Principal Scientist, Translational...
-
Boston, United States Pyxis Oncology Full timePosition: Principal Scientist, Translational Bioinformatics Hiring Manager: Head of Translational Medicine Location: Local to Boston, MA or Remote US Travel: [If Remote] Up to 20% of domestic travel Position Summary: Pyxis Oncology (‘PYXS’ or ‘Company’) is seeking an innovative, methodical and collaborative Principal Scientist, Translational...
-
Research Scientist
2 weeks ago
Boston, Massachusetts, United States Mass General Brigham Full timeJob SummaryWe are seeking a highly skilled and experienced Research Scientist to join our team at Mass General Brigham. As a Research Scientist, you will be responsible for leading an independent research project in our lab, working closely with the Principal Investigator and other researchers to advance our research goals.Key ResponsibilitiesProject...
-
Boston, Massachusetts, United States Takeda Full timeResearch Senior Scientist: IO Biology Cell EngagersAt Takeda, we are committed to transforming the pharmaceutical industry through our R&D-driven market leadership and values-led approach. As a Research Senior Scientist: IO Biology Cell Engagers, you will be a vital contributor to our inspiring mission to deliver Better Health and a Brighter Future to people...
-
Research Scientist
4 months ago
Boston, United States Massachusetts General Hospital Full timeResearch Scientist-(3292171) Description GENERAL SUMMARY/ OVERVIEW STATEMENT The Diabetes in Pregnancy Research Program seeks an enthusiastic Research Scientist to join our research team and advance our mission to “.” The Research Scientist, in collaboration with a multidisciplinary team, will play an instrumental role in bringing scientific...
-
Principal/Staff Market Research
5 days ago
Boston, United States Vizit Full timeAbout the CompanyVizit is the world’s first visual intelligence company. Designed by leading experts in AI and computer vision, Vizit’s revolutionary Visual Brand Performance Platform helps companies measure, understand, and optimize their Visual Brands to drive more sales, engagement, and connection with their target consumer audiences. The world’s...
-
Principal/Staff Market Research
5 days ago
Boston, United States Vizit Full timeAbout the CompanyVizit is the world’s first visual intelligence company. Designed by leading experts in AI and computer vision, Vizit’s revolutionary Visual Brand Performance Platform helps companies measure, understand, and optimize their Visual Brands to drive more sales, engagement, and connection with their target consumer audiences. The world’s...
-
Principal Scientist, Preclinical Pharmacology
1 month ago
Boston, United States OSI Full timePrincipal Scientist, Preclinical PharmacologyPosition SummaryPepGen is seeking a highly motivated and innovative Principal Scientist to join the Preclinical Research and Development group in Boston, Massachusetts. We are looking for a senior scientist who brings enthusiasm, curiosity, scientific rigor, and a desire to transform the future of neuromuscular...
-
Research Scientist
6 days ago
Boston, Massachusetts, United States Mass General Brigham Full timeJob SummaryWe are seeking a highly skilled Research Lab Tech II to join our team at Mass General Brigham. The successful candidate will be responsible for conducting independent and collaborative research in diagnostic microbiology and molecular biology.Key ResponsibilitiesConduct specialized antimicrobial susceptibility testing and develop molecular...
-
Principal Scientist, Preclinical Pharmacology
4 months ago
Boston, United States PepGen Full timeJob DescriptionJob DescriptionPrincipal Scientist, Preclinical PharmacologyPosition SummaryPepGen is seeking a highly motivated and innovative Principal Scientist to join the Preclinical Research and Development group in Boston, Massachusetts. We are looking for a senior scientist who brings enthusiasm, curiosity, scientific rigor, and a desire to transform...
-
Principal Scientist, Preclinical Pharmacology
2 weeks ago
Boston, United States PepGen Full timePrincipal Scientist, Preclinical Pharmacology Position Summary PepGen is seeking a highly motivated and innovative Principal Scientist to join the Preclinical Research and Development group in Boston, Massachusetts. We are looking for a senior scientist who brings enthusiasm, curiosity, scientific rigor, and a desire to transform the future of neuromuscular...
-
Principal Scientist, Preclinical Pharmacology
2 weeks ago
Boston, United States PepGen Full timePrincipal Scientist, Preclinical Pharmacology Position Summary PepGen is seeking a highly motivated and innovative Principal Scientist to join the Preclinical Research and Development group in Boston, Massachusetts. We are looking for a senior scientist who brings enthusiasm, curiosity, scientific rigor, and a desire to transform the future of neuromuscular...
-
Principal Scientist, Preclinical Pharmacology
2 months ago
Boston, United States OSI Full timePrincipal Scientist, Preclinical PharmacologyPosition SummaryPepGen is seeking a highly motivated and innovative Principal Scientist to join the Preclinical Research and Development group in Boston, Massachusetts. We are looking for a senior scientist who brings enthusiasm, curiosity, scientific rigor, and a desire to transform the future of neuromuscular...
-
Research Scientist
2 weeks ago
Boston, Massachusetts, United States Massachusetts General Hospital Full timeJob SummaryWe are seeking a highly skilled Research Scientist to join our team at Massachusetts General Hospital. The successful candidate will play a key role in advancing our mission to improve the health and well-being of pregnant and lactating individuals.Key ResponsibilitiesAssist the Principal Investigator in designing and overseeing clinical and...
-
Research Scientist II
7 hours ago
Boston, Massachusetts, United States Mass General Brigham Full timeJob Title: Research Lab Tech IIJob Summary:The Research Lab Tech II position involves conducting research and administrative tasks in a laboratory setting. Under the supervision of the Principal Investigator, the Research Lab Tech II will conduct independent and collaborative research involving molecular biology and microbiology techniques.Key...
-
Principal Scientist, Preclinical Pharmacology
3 months ago
Boston, United States PepGen Full timePosition SummaryPepGen is seeking a highly motivated and innovative Principal Scientist to join the Preclinical Research and Development group in Boston, Massachusetts. We are looking for a senior scientist who brings enthusiasm, curiosity, scientific rigor, and a desire to transform the future of neuromuscular and neurodegenerative diseases. The successful...
-
Postdoctoral Research Fellow
7 days ago
Boston, Massachusetts, United States Dana-Farber Cancer Institute Full timeJob SummaryWe are seeking a highly motivated Postdoctoral Research Fellow to join our laboratory at Dana-Farber Cancer Institute and Harvard Medical School. The successful candidate will support our research in radiation oncology, cancer biology, and imaging technologies.ResponsibilitiesDesign, conduct, and validate hypothesis-driven and...
-
Principal LLM Machine Learning Scientist
3 months ago
Boston, United States DeepRec.ai Full timePrincipal Machine Learning Scientist (Large Language Models)Location: Onsite in Cambridge, Massachusetts, USADeepRec.ai seeks a dedicated Principal level Machine Learning Scientist specializing in Large Language Models (LLMs), to join our client's innovative team in Cambridge, Massachusetts.Key Responsibilities:Fine-tune, scale, and deploy large language...
-
Principal LLM Machine Learning Scientist
3 weeks ago
Boston, United States DeepRec.ai Full timePrincipal Machine Learning Scientist (Large Language Models)Location: Onsite in Cambridge, Massachusetts, USADeepRec.ai seeks a dedicated Principal level Machine Learning Scientist specializing in Large Language Models (LLMs), to join our client's innovative team in Cambridge, Massachusetts.Key Responsibilities:Fine-tune, scale, and deploy large language...
-
Research Scientist
2 weeks ago
Boston, Massachusetts, United States Code Metal Full timeJob Opportunity at Code MetalWe are seeking a highly skilled Research Scientist to join our team at Code Metal, a leading company in the field of artificial intelligence. As a Research Scientist, you will play a key role in advancing our research and development efforts in machine learning and deep learning.Key ResponsibilitiesDesign and develop novel...