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Modeling and Simulation PK/PD Scientist

4 months ago

Indianapolis, Indiana, United States Eli Lilly and Company Full time

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

Lilly is on the forefront of groundbreaking research and the portfolio encompasses small molecules, peptides, antibodies, genetic medicines, RNA therapeutics and more. The PK/PD organization applies a variety of model-based approaches including PBPK, PK/PD, QSP and pharmacometrics to impact across this portfolio from early discovery to clinical submission and beyond. The Global PK/PD and Pharmacometrics Department at Lilly is seeking dynamic, energetic, curious, and collaborative quantitative scientists ready to engage and work on life-changing therapies for patients. You will interact with cross-functional teams using a variety of in silico approaches to inform drug discovery and development. Through engagement in experimental design and data interpretation, you will help drive and deliver the portfolio with a focus in the discovery space. Our aim is to find the right dose of the right drug for the right patient, embodying the model-informed drug discovery and development (MIDD) paradigm.We are passionate about making an impact in the lives of our patients and pushing the boundaries of science. Consider joining Team Lilly in Indianapolis to contribute to Lilly's drug discovery and development effortsResponsibilities:You will be responsible for developing and applying quantitative models to the discovery into development of therapeutic drug candidates. We are seeking modeling and simulation minded scientists to contribute to a team environment as we use diverse analytical and computational tools to characterize factors influencing the pharmacokinetic and pharmacodynamic properties of our drugs. We need a dynamic and driven scientist who is able to:

Integrate quantitative approaches into drug discovery.Conduct modeling and simulation to inform drug discovery and translation of drug properties.Communicate quantitative data, both internally and in the scientific community.Provide scientific leadership to project teams to support the selection of the right target, molecule, dose, patient population, and development strategies.Basic Qualifications:PhD in Pharmacometrics, Pharmacokinetics/Pharmacodynamics, Clinical Pharmacology, DMPK, Pharmaceutics, Computational Sciences, Engineering, or a related fieldIndustry or academic experience in PBPK, QSP, PK/PD, Clinical Pharmacology, exposure-response modeling, or other modeling & simulation related fieldExperience using relevant software such as Phoenix, NONMEM, R, SimCYP, Gastroplus, Monolix, Python, MATLAB, or similarAdditional Skills/Preferences:Adept at working with cross-functional colleaguesThorough understanding of pharmacokinetics and/or pharmacodynamic principles along with an ability to clearly communicate theories and conceptsExcellent self-management and organizational skillsDemonstrated strong communication skills Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively "Lilly") are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women's Network, Working and Living with Disabilities. Learn more about all of our groups. #WeAreLilly