Antibody Discovery Research Associate

1 month ago

Newton, United States Invivyd Full time


ABOUT US

There are more than 9 million immunocompromised people in the United States. Almost half a million of those represent a population that are moderately to severely immunocompromised and at highest risk for severe COVID-19, including stem cell and solid organ transplant patients as well as those with hematologic cancers.

At Invivyd, Inc., we take those numbers very seriously and we come to work each day on a mission to deliver protection from serious viral infectious diseases, beginning with SARS-CoV-2. Our proprietary INVYMABTM platform approach combines state-of-the-art viral surveillance and predictive modeling with advanced antibody engineering, designed to facilitate the rapid, serial generation of new monoclonal antibodies (mAbs).

Join an incredible team of innovators, disrupters, predictive modelers, and antibody engineers who embrace a shared sense of ownership, a passion to save lives, think boldly and creatively, take targeted risks, are unafraid of failure, and welcome change as a positive catalyst to new opportunities.

This is your chance to be part of the company with the first mAb authorized in over a year and the only one currently on the market for pre-exposure prophylaxis of COVID-19 in certain adults and adolescents (12 years of age and older weighing at least 40 kg) with moderate-to-severe immune compromise.

Be part of making a difference. Be part of Invivyd.

Job Title: Antibody Discovery Research Associate

In this role you will operate a cutting-edge antibody discovery platform and apply a breadth of techniques in the molecular biology, virology and immunology spaces to advance innovative biotherapeutic products through discovery and pre-clinical development stages at Invivyd. This is a unique opportunity to join Invivyd's Antibody Discovery and Preclinical Development Team which generates and characterizes human therapeutic antibody candidates against infectious disease targets like SARS-CoV-2 and influenza. The Antibody Discovery Research Associate will serve as a key member of the discovery team, provide expert input, and execute new and established methods to meet project requirements and timelines.

Responsibilities:

  • Perform experiments involving in vitro screening and characterization of antibody drug candidates using immunological, biochemical, and cell-based assays.
  • Contribute to high-impact projects within the Discovery group by generating lead antibody molecules for pre-clinical studies and key mechanistic characterization data.
  • Participate in the construction and screening of yeast display antibody libraries via flow cytometry.
  • Learn multiple antibody discovery platforms including B cell cloning, yeast display, and in vivo antibody discovery.
  • Assist and execute FACS-based Isolation of primary immune cells and perform immunophenotyping or biofunctional assays of mammalian primary immune cells.
  • Execute basic molecular biology (DNA manipulation such as RNA extraction, RT-PCR, PCR, cloning, etc.) and Cell Biology (mammalian cell culture, gene transfection and expression) assays to support antibody discovery efforts.
  • Collaborate closely across an interdisciplinary biologics research team to drive antibody discovery campaigns.
  • Support the molecular cloning of antibody gene sequences and perform recombinant expression in various scales using mammalian transient methods.
  • Employ high-throughput molecular biology methods for building new vectors, libraries, and their manipulation; or for reformatting between scFvs. Fabs and IgGs.
  • Maintain appropriate records e.g. lab notebook, protocols, reports, data integrity.
  • Present data, both orally and as written reports, to internal stakeholders.

Requirements:

  • Master's degree or Bachelor's degree and 2+ years of bench Industry experience in biochemistry, molecular biology or other life science disciplines
  • Strong understanding of flow cytometry, FACSs sorting, and MACS enrichment assays.
  • Previous experience with biochemical assays and yeast/phage surface display technologies design is highly preferred.
  • Proficient in mammalian cell culture and protein expression in mammalian cells.
  • Aseptic technique and culture of mammalian (must have) and/or yeast cells; mammalian cell transfection with an understanding of expression vector design.
  • Proactive team player and flexibility to work on multiple projects as the discovery programs evolve over time.
  • Ability to design and execute antibody discovery workflows and interpret in-process readouts.
  • Excellent verbal and written technical and non-technical communication skills.

At Invivyd we strive to create a welcoming and inclusive environment. Here all applicants will receive equal consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other applicable legally protected characteristics.

Invivyd is proud to be an equal opportunity employer.



We do not accept unsolicited resumes from agencies.



We do not accept unsolicited resumes from agencies.

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