Expert Scientist, Cell Line Development

4 weeks ago

Cambridge, Massachusetts, United States GlaxoSmithKline Full time
At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease.

We believe the Greater Boston area is an important hub for the biotech and pharma industry, which is why we've invested in growing our footprint and expanding our R&D space in Cambridge, with a primary focus on additional state-of-the-art lab space. Here, we will bring together talent and expertise, building upon GSK's long history of vaccine development, to create globally leading viral capabilities and cutting-edge vaccines technologies, as we add to our robust portfolio targeting infectious diseases at every stage of life.

The Mammalian Expression Technology Center of Excellence, Technical Research & Development, GSK Vaccines is responsible for the development of CHO based production cell lines, next-gen cell line engineering and baseline upstream process for innovative recombinant protein/adjuvanted vaccine projects and platforms.

The MET CoE is looking for a motivated technical expert for developing commercial CHO based cell line for recombinant protein-based vaccines. Located in Cambridge, MA, the position will play a significant role in shaping current and next generation GSK's leading vaccine platforms to accelerate addressing unmet medical needs, an exciting field having a direct impact into patients and global health. This role provides the opportunity to integrate a diverse group of top talented experts in vaccines' industry, lead key activities and further grow and progress in your career. These activities will include:
  • Hands-on design and development of commercial CHO cell lines for recombinant protein-based vaccines by harnessing the understanding in cell x molecule x process.
  • Key technical leader to development and implement innovative cell line expression system and high throughput data-driven cell line derivation workflow to enable rapid delivery of antigen-expression cell lines with robust productivity and quality.
  • Work within a global team (US and BE), collaborate transversally with other DS teams, Analytical R&D, etc., in an agile and open way ensuring good communication and alignment for project milestone delivery.
  • Stay ahead with the latest quality and regulatory guidance/strategy to support project documentation (as it is related to cell line raw material control strategies and cell line derivation technical reports) to accelerated CMC submissions.


The successful applicant may spend 3-6 months within the first year of hire in Rockville, MD to support and guarantee a smooth transition of methods and know-how to the new laboratories in Cambridge, MA.

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:
  • Ph.D. in Biochemistry, Molecular Biology, Chemical Engineering, Biotechnology or Bioengineering with 2+ years of laboratory experience.
  • MS in Biochemistry, Molecular Biology, Chemical Engineering, Biotechnology or Bioengineering with 5+ years of laboratory experience.
  • BS in Biochemistry, Molecular Biology, Chemical Engineering, Biotechnology or Bioengineering with 8+ years of laboratory experience.
  • Two or more years of experience in CMC development space for commercial grade mammalian cell lines for drug substance production.
  • Two or more years of experience with advanced automated cell line derivation/analytic instruments (Including Beacon optofluidic system) for novel biomolecules.
  • One or more years of experience in cell and molecular biology as it is related to Omics space (proteomic, genomic, epigenomic and transcriptomic).


Preferred Qualifications:

If you have the following characteristics, it would be a plus:
  • Deep understanding in Drug Substance CMC space (Technical, quality and regulatory aspects) as it is related to cell line development.
  • Demonstrated capability of implementing QbD principle to guide designing and selection of robust expression cell lines.
  • Ability to embed advanced data analytics and data sciences into cell line derivation workflow for accelerated project delivery with an ambition to move towards in-silico modelling to enable early selection of lead cell lines.
  • Operational knowledge with high throughput process tools (e.g. high throughput small scale bioreactor and process analytics) as it is related to cell line selection.

#Vx-Cam

#LI-GSK

Please visit GSK US Benefits Summary t o learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at US Toll Free) or outside US).

GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

Important notice to Employment businesses/ Agencies

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.

  • Expert Scientist

    5 days ago

    Cambridge, Massachusetts, United States GlaxoSmithKline Full time

    About the RoleWe are seeking a highly motivated and experienced Cell Line Engineer to join our team at GlaxoSmithKline (GSK). As an expert in cell line engineering, you will play a key role in shaping our next-generation vaccine platforms and accelerating the discovery of novel gene targets in CHO cells.Key ResponsibilitiesDesign and develop omics-based...

  • Expert Scientist, Cell Line Engineering

    4 weeks ago

    Cambridge, Massachusetts, United States GlaxoSmithKline Full time

    A career in Boston - main video - YouTube At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. We believe the Greater Boston area is an important hub...

  • Research Scientist, Cell Biology

    4 days ago

    Cambridge, Massachusetts, United States GC Therapeutics Full time

    About GC TherapeuticsGC Therapeutics is a pioneering genome-wide cell landscape exploration company that leverages an integrated synthetic biology and AI-driven platform for cell programming. Our patent-pending and proprietary pluripotent stem cell differentiation technology platform, TFomeTM, was developed in collaboration with Professor George Church's...

  • Cell Pharmacology Research Scientist

    2 weeks ago

    Cambridge, Massachusetts, United States Novartis International AG Full time

    Position OverviewAs a Research Scientist specializing in Cell Pharmacology, you will play a crucial role in advancing our understanding of drug interactions at the cellular level. Your expertise will be essential in the following areas:Target Identification and Validation: Engage in projects aimed at identifying and validating new therapeutic...

  • Scientist in Cell Pharmacology Research

    2 weeks ago

    Cambridge, Massachusetts, United States Novartis Group Companies Full time

    Position OverviewWe are looking for a dedicated in vitro Research Scientist to join our Cell Pharmacology division. This role is crucial in enhancing our comprehension of disease mechanisms, aiding in target identification, and contributing to the discovery and refinement of innovative therapeutic agents. You will collaborate with multidisciplinary research...

  • Cell Pharmacology Research Scientist

    2 weeks ago

    Cambridge, Massachusetts, United States Novartis International AG Full time

    Position OverviewAs a Research Scientist focusing on Cell Pharmacology, you will play a crucial role in advancing our understanding of drug interactions at the cellular level. Your expertise will contribute to various projects aimed at identifying and validating therapeutic targets.Key ResponsibilitiesConduct research on target identification and...

  • Cell Pharmacology Research Scientist

    2 weeks ago

    Cambridge, Massachusetts, United States Novartis International AG Full time

    Position OverviewAs a Research Scientist specializing in Cell Pharmacology, you will play a pivotal role in advancing our understanding of drug interactions and mechanisms. Your expertise will contribute to the identification and validation of therapeutic targets.Key ResponsibilitiesConduct innovative research on target identification and validation.Engage...

  • Scientist, Analytical Development

    2 months ago

    Cambridge, Massachusetts, United States Adaptimmune Full time

    Adaptimmune is a clinical-stage biopharmaceutical company focused on the development and commercialization of novel immunotherapy products for people with cancer. The Company's unique SPEAR (Specific Peptide Enhanced Affinity Receptor) T-cell platform enables the engineering of T-cells to target and destroy cancer across multiple solid tumors.Our company...

  • Expert Scientist mRNA Vaccine Development

    5 days ago

    Cambridge, Massachusetts, United States GlaxoSmithKline Full time

    About the RoleWe are seeking a highly skilled and experienced Expert Scientist to join our team at GlaxoSmithKline (GSK) in the development of mRNA-based vaccines. As a key member of our research team, you will play a critical role in leading, designing, and executing scientific studies to support the development of new mRNA-based vaccines.Key...

  • Analytical Development Group Leader

    7 days ago

    Cambridge, Massachusetts, United States Adaptimmune Full time

    Job SummaryWe are seeking an experienced Analytical Development Group Leader to join our Process and Analytical Development team at Adaptimmune. As a subject matter expert in analytical assays development, you will lead early-stage and late-stage analytical assays development/optimization and tech transfer of release and characterization testing for clinical...

  • Scientist Researcher

    16 minutes ago

    Cambridge, Massachusetts, United States SIMCERE OF AMERICA, INC Full time

    Job Title: Associate ScientistSimcere of America, Inc. is seeking a highly motivated and experienced Associate Scientist to join our dynamic drug discovery team in Cambridge, Massachusetts.About the Role:We are looking for a talented scientist to enhance our preclinical research division. This role presents an exciting opportunity to leverage your scientific...

  • Research Scientist

    2 weeks ago

    Cambridge, Massachusetts, United States GC Therapeutics Full time

    Become a part of our visionary teamAt GC Therapeutics, we are at the forefront of genome-wide cellular research. Our innovative methodology merges synthetic biology with artificial intelligence to enhance cell programming. Our state-of-the-art technology platform, TFomeTM, facilitates the creation of revolutionary cell therapies that prioritize quality and...

  • Lead Scientist in Biological Research

    2 weeks ago

    Cambridge, Massachusetts, United States Third Rock Ventures Full time

    Lead Scientist in Biological ResearchAn innovative startup backed by Third Rock Ventures is transitioning from stealth mode and is on the lookout for a skilled Lead Scientist to join its pre-clinical Biology team. This role will focus on a discovery-stage pipeline targeting antibody-related diseases. The Lead Scientist will be responsible for spearheading in...

  • Senior Scientist

    1 week ago

    Cambridge, Massachusetts, United States GC Therapeutics Full time

    Job Title: Senior Scientist - Assay DevelopmentGC Therapeutics is a pioneering genome-wide cell landscape exploration company that leverages an integrated synthetic biology and AI-driven platform for cell programming. Our patent-pending and proprietary pluripotent stem cell differentiation technology platform, TFomeTM, was developed in Professor George...

  • Scientist/Sr. Scientist, LNP Analytical Development

    1 month ago

    Cambridge, Massachusetts, United States Beam Therapeutics Full time

    Company OverviewBeam Therapeutics is committed to establishing the leading, fully integrated platform for precision genetic medicines. To achieve this vision, Beam has assembled a platform that includes a suite of gene editing and delivery technologies and is in the process of building internal manufacturing capabilities. Beam's suite of gene editing...

  • Research and Development Scientist

    1 week ago

    Cambridge, Massachusetts, United States GC Therapeutics Full time

    Job SummaryWe are seeking a highly motivated and talented Senior Research Scientist to support the qualification and validation of assays for the testing, characterization, and release of novel Pluripotent Stem Cell (PSC) derived products.Key ResponsibilitiesDesign, develop, and validate assays for testing the safety and efficacy of stem cell-derived drug...

  • Lead Scientist in Biological Research

    2 weeks ago

    Cambridge, Massachusetts, United States Third Rock Ventures Full time

    Lead Scientist in Biological ResearchA dynamic and well-supported startup backed by Third Rock Ventures is transitioning from stealth mode and is in search of a skilled Lead Scientist to join the Biology pre-clinical team. This position will involve taking charge of the Biology team for a discovery-stage pipeline program(s) that target antibody-mediated...

  • Scientist / Senior Scientist - Discovery & Protein Sciences

    4 weeks ago

    Cambridge, Massachusetts, United States UCB Full time

    Make your mark for patients To strengthen our Discovery Sciences and Protein Sciences teams in our Boston hub in Cambridge, MA, USA, we are looking for a talented individual to fill the position of: Scientist or Senior Scientist. As (Senior) Scientist, you will contribute to a scientific team as protein biochemist and cellular biologist. You will generate...

  • Lead Protein Scientist

    2 weeks ago

    Cambridge, Massachusetts, United States Bristol-Myers Squibb Full time

    Join Our TeamAt Bristol Myers Squibb, we offer a unique opportunity to engage in work that is both challenging and rewarding. Our environment fosters innovation and collaboration, allowing you to contribute to groundbreaking advancements in biopharmaceuticals. You will be part of a diverse team that is dedicated to transforming the lives of patients through...

  • Expert Scientist Upstream Process Development

    5 days ago

    Cambridge, Massachusetts, United States GlaxoSmithKline Full time

    Job Summary:We are seeking a highly motivated and experienced Upstream Process Development Expert Scientist to join our team at GlaxoSmithKline. As a key member of our mRNA Drug Substance team, you will play a critical role in developing and optimizing RNA in-vitro transcription processes to translate into the mRNA platform.Key Responsibilities:Design,...