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Associate Director, Pharmacometrics

4 months ago

Chicago, Illinois, United States AbbVie Full time

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us Follow @abbvie onTwitter,Facebook,Instagram,YouTubeandLinkedIn.
Job Description

Purpose:

Conceives, executes and effectively manages and communicates multi-disciplinary modeling and simulations exercises to support development plans and strategies to achieve commercial goals and regulatory requirements for multiple functions. Generates new PK/PD modeling and simulation proposals and leads those efforts. Anticipates and critically evaluates Statistical, PK/PD, Clinical Pharmacology, or regulatory advances, strengths, weaknesses, opportunities and threats, and responds with appropriate new strategies. Consistently demonstrates excellent record of accomplishment of Pharmacometric and business objectives. Leads Pharmacometric and PK/PD modeling aspects of multiple projects and indications. Responsible for critically evaluating technical and scientific aspects along with Clinical Pharmacology and Pharmacometrics management.

Responsibilities:

Executes strategy, lead teams and various data analyses and interpretation by providing necessary context (including explaining MoA and disease specifics, available relevant internal and external data, analysis plans, interpretation and discussion of model results in the context of research question).Author regulatory documents including analysis plans, study reports, population PK reports, exposure response analyses reports, label, white papers, and other similar documents.Present at various departmental and cross functional teams such as study teams, Clinical Pharmacology leadership team, Journal club.Drives small teams with members from Pharmacometrics functional groups to provide a unified modeling and simulation position to clinical, CMC and regulatory teams.Responsible for the appropriateness, quality and accuracy of pharmacometrics deliverables. Advice on complex methodologies such as advanced analytics, machine learning and mechanistic modelingContribute to development of departmental goals. Influences strategic PK/PD decisions for the department.Champion development, implementation, and promotion of innovative PMx approaches across therapeutic areas.Participate in internal and external initiatives/working groups (e.g., cross-functional initiatives, process harmonization, IMI calls, ISoP groups).May manage personnel including their development, mentoring, and effective delegation.Authors scientific publications and present at national and international conferences and interact with external stakeholdersNONMEM and R will be required. Continuous sitting for prolonged periods (more than 2 consecutive hours in an 8 hr day) is required
Qualifications
PhD with typically 5+ years of experience in a relevant field, Masters Degree or equivalent education and typically 11+ years of experience, Bachelors Degree or equivalent education and typically 15+ years of experience;(*relevant field includes experience with data science, mathematics, biostatistics, modeling and simulation, Pharmacometrics or systems pharmacology)Excellent interpersonal skillsAbility to interact with functional representatives internally and externally and lead modeling and simulation teamsStrategic thinking and enterprise viewProven scientific track record and technical skills to perform the roleKey Leadership Competencies:Delivers business results while also positioning AbbVie for long-termsuccess.Persistent and resilient finds the way to move good ideas forward o Acts respectfully yet courageously.Connects unrelated concepts, generates original or unique ideas.Influences colleagues to achieve cross-functional alignment.
Additional Information
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: The compensation range described below is the range of possible base pay compensation that the Company believesingood faith it will pay for this role at the time of this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, and we mayultimatelypay more or less than the posted range. This range may be modified in the future. We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligible employees. This job is eligible to participate in our short-term incentive programs. This job is eligible to participate in our long-term incentive programs. Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensationand benefitsthat are allocable to a particular employee remains in the Company's sole and absolute discretion unless anduntil paid andmay be modified at the Companys sole and absolute discretion, consistent with applicable law. AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVies policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.