Scientist, RNA Chemistry

4 weeks ago

Waltham, Massachusetts, United States Dyne Therapeutics Full time
Company Overview:

Dyne Therapeutics is a clinical-stage muscle disease company focused on advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCETM platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle tissue. Dyne has a broad pipeline for serious muscle diseases, including clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and a preclinical program for facioscapulohumeral muscular dystrophy (FSHD).

Role Summary:

As a member of the Platform Oligonucleotide innovation team, the successful candidate will contribute to the development of Dyne's oligonucleotide chemistry platform and enable the discovery of novel nucleic acid therapeutics. This individual will be responsible for the design, synthesis, purification, and analysis of oligonucleotides and their conjugates. The successful candidate should have technical expertise in modified RNA synthesis and experience with key biochemical assays to measure RNA stability and mode of action.

This role is based in Waltham, MA without the possibility of being a remote role. Applicants must be able to relocate to the area.

Primary Responsibilities Include:

Perform synthesis of oligonucleotides with diverse sugar and backbone modifications at various scales
Troubleshoot and optimize synthesis methods to produce high quality oligonucleotides of various lengths
Interpretation of analytical data (HPLC, LCMS) to enable improved purity and yields of in-house synthesized oligonucleotides
Carry out purification (anion exchange, reverse phase), analysis (IP/RP, IEX, SEC), characterization (LCMS, UV, melting temperature) of oligonucleotides and their conjugates
Perform standard biochemical assays to determine stability and mechanism of action of oligonucleotides
Contribute both technically and rationally to the hit-to-lead optimization process
Cross-functional collaboration to define deliverables and timelines
Multi-task across several projects and manage time effectively to achieve results
Collect, present, and discuss data at internal team meetings

Education and Skills Requirements:
PhD in chemistry or biochemistry or MSc with at least 3-5 years of industrial experience in the biotechnology industry, or BSc with 5+ years experience
Prior experience with the operation of oligonucleotide synthesis and purification equipment is highly valued
Familiarity with biochemical assays (RNA stability, gel shift assays, DNA/RNA cleavage assays) is preferred
Experience with enzymatic reactions (RNA ligation, IVT, PCR) is preferred
Collaborative team player

#LI-Onsite
The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.
This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time. The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.
Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

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