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Principal Research Scientist II
4 months ago
Company Description
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.
Job Description
Purpose:
Within the Predictive Stability and Structural Elucidation group, part of the global Analytical R&D organization, conceive and implement novel experimental approaches to answer a broad spectrum of scientific questions as they relate to process and degradation chemistry for both drug substance and drug product development. These investigations include: elucidation of unknown chemical structures from complex mixtures using high resolution mass spectrometry and other related techniques, drug impurity/degradant profiling, isolation of unknown drug degradation products, probing studies to determine degradation reaction mechanisms, modeling of accelerated stability data to predict shelf-life. Contribute to project science within multidisciplinary teams, and develop productive collaborations, work processes and communications with other groups across drug product development disciplines.
Responsibilities:
Routinely demonstrate scientific initiative and creativity in research or development activities.Highly autonomous and productive in designing and performing laboratory research or method development.Formulate conclusions and design follow-on experiments based on multidisciplinary data.Process, interpret, and visualize data to facilitate project team decisions.Initiate new areas of investigation that are scientifically meaningful, reliable, and can be incorporated directly into a research or development program.Demonstrates high proficiency across a wide range of relevant technologies.Maintain a high level of productivity in the lab.Present and publish work in high level journals and at conferences.May supervise and/or mentor junior level scientists.Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, controlled drug and radioactive compounds, GxP compliance, and animal care where applicable. Significant Work Activities -Continuous sitting for prolonged periods (more than 2 consecutive hours in an 8 hour day)Qualifications
Qualifications: Ph.D. or M.S.-level education in Biomaterials Science, Polymer Chemistry, Bioengineering, Chemical Engineering, Biochemistry, Pharmaceutical Sciences, Drug Delivery Sciences, or related fields.8+ (Ph.D.), 14+(M.S.) or 16+ (B.S.) years of applicable experience including industrial experience is required.Practical Experience and strong knowledge of modern HPLC, structural elucidation and mass spectrometry techniques as applied to pharmaceutical development.Must possess a solid understanding of organic chemistry and structural elucidation, particularly as related to small molecule pharmaceutical drug development. In depth knowledge or skill in computational calculations to support mass spectral fragmentation is preferred.Proven effective written and verbal communication skills and ability to interact effectively with interdisciplinary scientists and engineers.High attention to detail, creativity in problem solving, strong interpersonal skills and proven ability to successfully work independently and as part of teams.Excellent analytical problem-solving skills. Capable of independently developing and troubleshoot analytical methods.Demonstrated hands on experience with laboratory automation hardware and software.Ability to work on multiple and simultaneous projects as part of a team in a global, fast-paced, setting where priorities may change quicklyExhibit a can-do attitude with excellent interpersonal and communication skills
Additional Information
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.This job is eligible to participate in our short-term incentive programs. Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion, consistent with applicable law. AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVies policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.
