Principal Scientist
1 month ago
Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: .
When you join BMS, you are joining a diverse, high-achieving team united by a common mission.
The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as bispecific antibodies, antibody drug conjugates and endogenous proteins in order to optimize their utility as therapeutic agents. We collaborate with biology and translational scientists imbedded in the Thematic Research Centers in order to prosecute Targets and Biological pathways with disease modifying potential. By using a blend of internal and external technologies and capabilities, we work to discover and deliver first-in-class as well as best-in-class molecules that warrant clinical evaluation for patient benefit.
Here, you'll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You'll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.
We are seeking a highly motivated and innovative Principal Scientist to join the Discovery Biotherapeutics Department in San Diego. The ideal candidate will possess a demonstrated expertise in protein sciences including protein expression and purification, process optimization, biochemistry, and automation. Responsibilities will include a range of activities related to protein expression, purification, and cell line development; and the ideal candidate will be proficient in the design, optimization, and execution in transient and stable protein expression, multi-step purification, analytical data interpretation, troubleshooting and formulation of final product, while maintaining a highly productive and collaborative culture.
Specifically, the successful candidate will:
- Execute multiple and concurrent protein production projects to enable downstream R&D activities. Productions will utilize several platforms, including transient Expi293, ExpiCHO, and stable CHO expression.
- Possess a detailed understanding of recombinant standard and alternative (bi-/multi-specific) antibody production methods and expression optimization.
- Identify and execute process improvements which may include, but are not limited to, cell culture optimization, cell line engineering, vectorology, automation, DOE, and scale-down/bench-scale bioreactors.
- Demonstrate a track record of initiative, creativity, organization, and independent performance at a high level combined with attention to detail and adherence to timelines/deliverables, and documentation.
- Participate on project teams to discover, optimize, and manufacture antibody-based biologics, and should be highly effective in collaborating with internal and external team members and CRO's.
- Special emphasis will be placed on automated antibody purification, which will involve working with GE AKTA (Pure/Avant) and Unicorn software.
- The candidate will show an independent ability to design purification methods, understand biochemical concepts and interpret data to generate and improve design.
- Antibody and bispecific purification: concentrating supernatants, preparation and packing of chromatography columns, and conducting endotoxin free chromatography, including operating preparative and analytical chromatography systems.
- Analytical characterization: Endotoxin measurements, protein quantitation assays, analytical HPLC chromatography (HIC, SEC), Capillary electrophoresis (CE-SDS and cIEF)
- Knowledge of analytical instruments such as spectrophotometers, analytical HPLC, capillary electrophoresis (CE-SDS, cIEF), plate readers.
- Storing, inventorying, and ordering department supplies and chemicals and preparing chemical solutions according to department procedures, specifications, or supervisory instructions.
- Participates on cross-functional teams by performing assigned experiments and offering technical advice at team meetings; shares technical expertise with other colleagues; trains or provides guidance to other personnel, if needed.
- Will maintain a neat, clean, and orderly work environment.
- Experience in external partnership management, due diligence for technology evaluation, project leadership and matrix management are a plus.
- Extensive hands-on experience with aseptic technique, cell culture, and transient and stable recombinant protein production and recombinant cell line development.
- Antibody/protein analysis and characterization including, but not limited to ELISA/ Octet, CE-SDS,
Bachelor's Degree with 8+ years of academia / Industry experience
Or
Master's Degree with 6+ years of academia / Industry experience
Or
PhD with 4+ years of academia / Industry experience
Preferred Qualifications:
- Bachelor's (B.S.) degree in biology, biochemistry, applicable sciences; with 8+ years of relevant industry, or a Master's degree with 6+ years relevant industry experience or a PhD with 4+ years of experience.
- Antibody purification is desired.
- Must be very detail-oriented and organized, with excellent time-management and multitasking skills.
- Have outstanding analytic and problem-solving abilities.
- Display excellent verbal and written communication, interpersonal and presentation skills, as well as the ability to interact tactfully and effectively with employees at all levels of the organizational structure.
- Must be highly self-motivated, detail-oriented, well organized and work effectively as part of a team.
- Bioreactor operations (Ambr15 microbioreactors, Wave bag, bench-scale single-use and glass).
- Automated liquid handling.
- Standard molecular biology methods, cloning, plasmid preparation, vector design, PCR, mutagenesis, and DNA sequence analysis.
- Plate based imaging, Flow cytometry/microscopy.
- Vector, cell line, and expression engineering and experimental design.
- Sample inventory management.
- Experience and knowledge of protein and antibody structure, sequences, engineering, display, folding, antibody databases and data management systems, and ELN.
- AnSEC, protein purification, etc.
- Exceptional organizational skills and attention to detail.
- Strong written and oral communication skills are essential.
- Excellent time management skills and multi-tasking capabilities.
Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as Transforming patients' lives through scienceTM , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
On-site Protocol
BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to . Visit eeo -accessibility to access our complete Equal Employment Opportunity statement.
BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
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