Scientist, Drug Metabolism

Job Description

Our company is a global healthcare leader with a diversified portfolio of prescription medicines, vaccines, and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where our company has codified its legacy for over a century. Our company's success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

At our company, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines that save and improve lives. Every employee is building on our proud legacy of scientific breakthrough. Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility, and scientific acumen of our team. We are creating a diverse organization that is inspired by invention and founded on a culture of respect and collaboration.

We are currently recruiting a Scientist to contribute to our company's drug discovery and clinical development efforts in the Department of Pharmacokinetics, Dynamics, Metabolism and Bioanalysis (PDMB). This position will be based at our research labs in West Point, PA.

The Drug Metabolism and Pharmacokinetics (DMPK) group within the PDMB function of our company's Research Laboratories is seeking a self-motivated, result-driven, collaborative scientist to contribute to our company's drug discovery efforts. The ideal candidate will primarily perform lab-based activities and be responsible for generating in vitro DMPK data using novel robotics systems to guide macrocyclic peptide candidate optimization and characterization efforts.

In this exciting role, your primary activities will include:

• Generation, interpretation, and documentation of high-quality laboratory data to support drug candidate selection
• Conduct of in vitro assays using enzymes, cell suspensions, tissue preparations, and subcellular fractions
• Build innovative high throughput methods using the latest automation and robotics platforms available.
• Qualitative bioanalysis using LC-HRMS (Liquid chromatography high resolution mass spectrometry), including assay development and troubleshooting.

Education Minimum Requirement:

• A bachelor's or master's degree in biochemistry, analytical chemistry, or related field with 0-3 years of relevant laboratory experience

Required Experience and Skills:

• Strong background in biochemistry and/or analytical chemistry
• Hands-on experience using LC-MS
• Desire to perform, interpret, and report hypothesis-driven in vitro ADME studies
• Desire to work with high throughput automation systems.
• Strong interpersonal, communication, problem solving, and collaborative attributes to deliver high quality results in a fast-paced environment.

Preferred Experience and Skills:

• Working knowledge of ADME-related assays, such as plasma protein binding, metabolic stability, and in vivo excretion.
• Experience with robotics and automation systems.
• Experience working within a research-driven pharmaceutical company.
• Experience using HRMS for peptide or large molecule characterization.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.

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U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".

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Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Relocation:

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Travel Requirements:

Flexible Work Arrangements:

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Job Posting End Date:

*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Job Posting End Date:08/23/2024

A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID:R308703