Senior Principal Scientist, Veterinary Pathology

Job Description

Our Company is a leading global biopharmaceutical company with over 125-year history of Inventing for Life with an inspiring mission to make discoveries that positively impact global healthcare. Our success is driven by putting patients first, operating with the highest integrity, and committing fully to our vision to make a difference in the lives of people globally. With our diverse pipeline of vaccines, biologics, small molecules, and newer modalities, we are at the forefront of research to advance the prevention and treatment of diseases such as cancer, cardiometabolic diseases, Alzheimer's disease, eye diseases, and infectious diseases including HIV, Ebola and SARS-Cov2.

Our Company's Research Laboratories' nonclinical safety assessment group at the West Point, Pennsylvania site is seeking an experienced anatomic pathologist to join a highly collaborative team of scientists (14 anatomic pathologists, 3 clinical pathologists, and approximately 40 exceptional technical staff), working at a GLP-compliant facility with state-of-the-art anatomic, molecular and clinical pathology laboratories. Our team works on a diverse and exciting pipeline, participating in a wide variety of GLP-toxicology study types, many of which are run in-house, in addition to early discovery and investigative studies.

Pathologists at our company are integral members and leaders of collaborative cross functional scientific teams, addressing challenges from early discovery to late development. Our Company's pathologists provide scientific leadership in the design and conduct of postmortem evaluation of studies and integrate the interpretation of postmortem data into the safety profile of drug candidates. Our Company's pathologists have diverse opportunities to learn and grow as professional scientists and drug developers through daily study related activities and collaborative works with diverse program development teams.

Key responsibilities for this scientific role include:

• Employ both routine H&E evaluations as well as other specialized techniques to characterize the safety profile of new drugs from toxicology and investigative studies
• Work independently to analyze data, interpret and determine the significance of results for postmortem evaluations, review literature and design experiments to help teams solve scientific problems
• Serve as Program Pathologist, providing scientific input and oversight across studies from very early discovery to late-stage development, following molecules throughout their lifetime
• Communicate with study team/drug development teams on study findings and participate on cross-functional teams to elucidate mechanisms of toxicity and may be required to provide advanced scientific and/or technical guidance to technical and/or Ph.D/D.V.M. level staff. Utilizing additional tools and applications that are all available on-site, including:
  • An industry-leading suite of on-site in vitro and in vivo assay capabilities
  • Access to robust historical controls slide archive and data base
  • Transmission electron microscopy
  • Immunohistochemistry and in situ hybridization
  • Quantitative digital image analysis and targeted machine learning applications
  • In vivo imaging tools (e.g., magnetic resonance imaging)
• Develop novel biomarkers and predictive models to de-risk drug candidates for safety-related liabilities
• Our Company's pathologists also serve as nonclinical safety assessment leads on drug development teams, overseeing the design and execution of studies, and generation of regulatory strategy and communications with global regulatory agencies to support the development of drug candidates
• Our Company's pathologists work in a hybrid work environment and routinely interact with each other, share slides and opinions/experiences, and help each other learn and grow

Required experience and skills:

• Love to collaborate with diverse cross-functional teams and communicate openly and often with colleagues
• Doctor of Veterinary Medicine (DVM)
• Residency in anatomic / toxicologic pathology
• ACVP or ECVP-board certification in anatomic pathology
• Over 5 years of experience as a pathologist in biotech, pharma or at a CRO

Preferred experience and skills:

• Demonstrated proficiency in histomorphology evaluation and interpretation of rodent carcinogenicity studies
• Strong knowledge of the drug discovery, development and regulatory processes, including experience on drug development project teams
• PhD in Toxicology, Pathology, or related discipline
• Experience in ophthalmic pathology

Our Company has a commitment to the continued professional development of all colleagues through training opportunities, publications, internal and external presentations, access to internal scientific seminars as well as support for external scientific meetings. With our location along the Northeastern US corridor, there are many opportunities to participate in cross-industry workshops, conferences, direct regulatory interactions and other training or networking opportunities. Imagine what you could achieve at our Company

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.

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U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".

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Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Relocation:

VISA Sponsorship:

Travel Requirements:

Flexible Work Arrangements:

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Valid Driving License:

Hazardous Material(s):

Job Posting End Date:

*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Job Posting End Date:09/30/2024

A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID:R306061