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Research Associate, Process Development

4 months ago

Pittsburgh, Pennsylvania, United States Krystal Biotech Full time

Upstream Process Development Research Associate
Who we are:
At Krystal Biotech, Inc., we bring together the brightest and most eager minds to relentlessly pursue the discovery, development and commercialization of gene delivery medicines for patients with serious and life-threatening genetic diseases. Founded in 2016, Krystal is a leader in gene therapy. Krystal received U.S. FDA approval for the first-ever redosable gene therapy treatment, VYJUVEKTM, for the treatment of Dystrophic Epidermolysis Bullosa. Krystal continues to leverage our proprietary platform to develop new treatments across a robust clinical pipeline.
Krystal Biotech is based in Pittsburgh, PA which is home to our two state-of-the-art GMP facilities. Additional offices are situated in Zug, Switzerland.
Join us on our journey to implement our mission to identify, develop and deliver genetic medicines to patients
Job Description Summary:
Krystal Biotech, Inc. is seeking a highly motivated and innovative Research Associate to support multidisciplinary efforts in Upstream Process Development.
The Research Associate will support process development initiatives by conducting experiments related to the characterization and optimization of viral vector production. They will also support the tech transfer of fully characterized processes to the Manufacturing team.
Qualified candidates will demonstrate basic knowledge in fundamental mammalian cell culture techniques. To be successful, this individual will show curiosity, initiative, and the ability to work well in a timeline-driven environment.
The Research Associate role will handle a variety of responsibilities, some of which include:

  • Support scientists/senior scientists in the upstream process team for upscaling HSV production
  • Perform mammalian cell culture using aseptic techniques
  • Prepare buffer and media solutions to support experiments in the lab
  • Provide technical support in the lab through equipment optimization projects and troubleshooting, as needed
  • Participate in study design and process development brainstorming sessions
  • Conduct experiments under defined conditions to verify/reject various types of hypotheses using refined scientific methods
  • Record all data and results with accuracy and responsibility
  • Ensure that all safety guidelines are always followed strictly and maintain a clean and orderly environment
  • Adhere to scientifically-sound practices for experiment documentation, statistically driven data analysis, and interpretation of results
  • Interact with cross-functional teams and effectively communicate scientific results
  • Other duties as assigned

Requirements and Preferred Qualifications:

  • Bachelor's Degree in Life Sciences or Engineering discipline with relevant industry benchwork experience
  • Some understanding in one or more of the following areas: aseptic technique, mammalian cell culture, bioreactor technology, cell biology, and/or virology
  • Familiarity with bioreactor operation and upstream process is a plus
  • Experience using core scientific techniques
  • High capability of multitasking in a fast-paced team-oriented environment
  • Excellent oral and written communication skills

Krystal Biotech, Inc. is an Equal Employment Opportunity and Affirmative Action Employers. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender perception or identity, national origin, age, marital status, protected veteran status, or disability status. Headhunters and recruitment agencies may not submit resumes/CVs through this Web site or directly to managers. Krystal Biotech, Inc. does not accept unsolicited headhunter and agency resumes. Krystal Biotech, Inc. will not pay fees to any third-party agency or company that does not have a signed agreement with Krystal Biotech, Inc.