Scientist II – Process Development
4 weeks ago
BlueRock Therapeutics, a wholly-owned and independently operated subsidiary of Bayer AG, is a leading engineered cell therapy company using its unique cell+gene platform to direct cellular differentiation and genetically engineer cells to create a new generation of cellular medicines that address large patient populations suffering from neurological, cardiovascular, and immunology diseases.
The convergence of cell biology and genetic engineering is creating fundamental new ways to impact disease. Founded in 2016 to capitalize on these technological breakthroughs, we are advancing our novel cell+gene platform to develop, manufacture, and deliver an entirely new generation of authentic and engineered cell therapies across three therapeutic areas: neurology, cardiology, and immunology.
What Are We Doing?Our foundational science harnesses the ability to create and then direct the differentiation of universal pluripotent stem cells into authentic, functional cells that can be used as allogeneic cellular therapies to treat a broad array of diseases. We can also further engineer these cells, enabling them to produce enzymes, antibodies, and other proteins for additional therapeutic benefit.
We are passionate about delivering on the promise of cellular and gene therapy, shaping the future of cellular medicine, and delivering new therapies to millions of patients with treatment options.
We are seeking individuals who are collaborative, thrive in a fun and dynamic culture, and are steadfast in the commitment to advance cutting-edge cellular therapies to impact patients' lives.
BlueRock Therapeutics is seeking a Scientist, Process Development based in our New York City, New York location. As a central development resource at the company, the Process Development team works with Research, Non-clinical, Analytical Development, GMP operations including Manufacturing, and Quality teams. As a key contributor within this function, the incumbent will help lead the optimization and scale up efforts of a closed and automated 3D platform for expansion of pluripotent stem cells. This is an outstanding opportunity for a talented and self-motivated scientist to gain valuable career experience in Process Development. We are seeking individuals who are collaborative, thrive in a fun and dynamic culture, and are steadfast in the commitment to advance cutting-edge cellular therapies to impact patients' lives. The role will be a predominantly lab based.
Responsibilities:
- Design, execute, oversee, and interpret experiments in partnership with other team members.
- Independently draft, review, and finalize both technical protocols and scientific reports while interacting in a cross- specialty environment.
- Help determine process parameters range for cell culture and downstream processing to optimize PSC starting material yield and quality in a bioreactor system.
- Identify important process parameters and implement appropriate analytics.
- Maintain and culture PSCs utilized as starting material for downstream differentiation. This includes regular weekend/holiday in-lab activities.
- Assess gaps in PSC maintenance and growth conditions for banking, including platform evaluation, GMP-readiness and scale up efforts.
- Collaborate, cross-functionally, to solve scientific problems outside of function.
- Coordinate with platform and research teams as well as other Tech Ops groups to prioritize and plan characterization and distribution of cell materials.
- Participate in tech transfer activities to Manufacturing.
- Analyze and document experimental data in electronic laboratory notebooks in a timely and accurate manner.
- Prepare and follow standard operating procedures, batch records, reports, and other process documentation.
- Mentor and motivate others in scientific and/or technical topics with the goal of enabling key activities to be completed appropriately and on-time.
- Organize and present scientific data to peers at internal platforms.
Minimum Requirements:
- Ph.D or MSc. degree in a Biological Science, such as Biochemistry, Immunology, Molecular Biology, or similar
- Ph.D 2+ years of experience or MSc. 10+ years of experience, preferably in an industry setting
- Extensive mammalian cell culture and cell characterization experience, ideally with PSCs
- Practical knowledge of experimental design (e.g., DoE) software and statistical analysis of data
- Understanding and experience of molecular techniques such as cell imaging, flow cytometry, or qPCR and ddPCR is desired.
- Ideally experience with Bioreactor cell culture and bioprocessing.
- Ability to plan experiments and independently execute complex tasks.
- Strong English written and verbal communications skills.
- Proficiency in technical scientific writing.
- Ability to work in a fast-changing environment.
- Collaborative team player
#LI-AL1
BlueRock Therapeutics Company Culture Highlights
Winner of Boston Business Journal's Best Places to Work (Mid-size Company) 2023
Winner of Comparably's Award for Best Company for Diversity 2022
Winner of Comparably's Award for Best Company for Women 2022
Winner of Comparably's Award for Best CEO 2022
BlueRock Therapeutics is ranked in the top 5% of companies for Overall Culture on Comparably.
Engineering Department is ranked in the top 5% of companies for Overall Culture on Comparably.
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Equal Opportunity Workplace: At BlueRock, we welcome and support differences and diversity and we are proud to be an equal opportunity workplace. Please let us know if you require disability-related accommodation or other grounds protected by human rights legislation during the recruitment process so that we can work with you to meet your needs.-
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