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Principal Scientist, Flow Cytometry

2 months ago

Collegeville, Pennsylvania, United States GlaxoSmithKline Full time
Site Name: USA - Pennsylvania - Upper Providence
Posted Date: Jul 2 2024

We are looking for a highly motivated, flexible and experienced scientist to join the Cellular Biomarkers Flow Cytometry team within Biomarker & Bioanalytical Platforms in the Precision Medicine department located in Upper Providence, US.

The team is responsible for the development and validation of complex multi-parameter flow cytometry panels and subsequent application of these panels to clinical trial sample analysis. The deep immunophenotyping data generated by these biomarker panels helps us to evaluate disease heterogeneity, drug-target engagement, drug mechanism of action and patient responses.

The successful candidate will have a deep understanding of immunology and will act as a flow cytometry technical expert, supporting high parameter deep immunophenotyping of immune cell subsets as well as receptor occupancy endpoints. This is a lab-based role and will include all aspects of flow cytometry method development and optimization, validation and sample analysis for clinical studies across the entire GSK portfolio.

This role will be responsible for completion of all aspects of assay workflow including reagent selection, sample preparation, sample acquisition, data analysis, interpretation and presentation. In addition, this role will ensure all work is conducted in compliance with GCP regulations including adherence to the appropriate SOPs.

In this role you will
  • Generate high quality data to support clinical studies by spectral flow cytometry (Cytek Aurora)
  • Conduct and oversee all aspects of method development, troubleshooting, validation and sample analysis for clinical studies
  • Handle human biological samples and perform experimental work in accordance with GCP regulations, safety assessments and data integrity guidelines
  • Be responsible for delivery of robust, high-quality data packages
  • Deliver, interpret and communicate complex scientific data to project/program teams within agreed timelines
  • Contribute to biomarker strategy and capital equipment discussions
  • Help lead efforts to investigate novel cytometry and data analysis platforms and embed them within the organization
  • Manage multiple projects concurrently
  • Function well in a team and possess a good balance of creative and analytical skills
  • Be willing to develop and train others as required


Why you?

Basic Qualifications:
  • Bachelors degree and six or more years' relevant experience or PhD with two or more years' experience
  • Two or more years' experience with immunological enabling phenotyping of multiple cell lineages
  • Two or more years' experience with flow cytometry and in design and execution of 16+ colour flow cytometry panels
  • Two or more years' of laboratory experience and expertise working with a variety of sample types including whole blood, PBMC, cell lines and single-cell suspensions from tissues


Preferred Qualifications & Skills:

If you have the following characteristics, it would be a plus:
  • A good understanding of the drug development process
  • Experience in design and execution of 22+ colour flow cytometry panels
  • In-depth knowledge of various immune subsets
  • In-depth knowledge of receptor occupancy assays
  • Hands on practical experience with the Cytek Aurora
  • Strong laboratory experience and understanding of clinical and non-clinical flow cytometry biomarker assay development, validation and implementation
  • Hands on experience with high-dimensional data analysis ( e.g. tSNE, UMAP, CITRUS, FlowSOM)
  • Experience of technology transfer of flow cytometry assays to Contract Research Organizations
  • Experience of writing SOPs and other regulated documents
  • Willingness to work with human samples infected with blood borne pathogens including HIV and HBV, etc.
  • Considerable experience in the use of flow cytometry analysis software (OMIQ preferred)
  • Ability to maintain a disciplined approach, ensuring a relentless focus on quality, compliance, scientific rigor, and operational excellence even when flexing between multiple projects
  • Attention to detail, good communication and documentation skills
  • Ability to work independently to tight deadlines with a proactive attitude
  • Be a highly motivated team player with the ability to interact effectively within a multi-disciplinary team
  • Ability to problem solve and troubleshoot
  • Good judgment and decision making, especially for prioritizing multiple requests


Please visit GSK US Benefits Summary t o learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

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