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Principal Scientist, Genomics, Cellular Biomarkers

3 months ago

Collegeville, Pennsylvania, United States GlaxoSmithKline Full time
Site Name: USA - Pennsylvania - Upper Providence
Posted Date: Aug

We have an exciting opportunity for a highly motivated, agile, and experienced scientist with lab level expertise in genomic technologies to join the Cellular Biomarkers Genomics group within the Biomarker and Bioanalytical Platform (BBP) department based in Collegeville, PA. Our group is responsible for development and use of genomics and proteogenomic biomarker assays in clinical studies.

You will serve as a technical expert in applied genomic and proteogenomic technologies and will generate data to support the understanding of disease heterogeneity, drug's mechanism of action, and patient response to treatment at the molecular level through application of advanced genomic technologies, including Next Generation Sequencing (NGS), Olink Proximity Extension Assay (PEA), single cell analysis, qPCR, dd-PCR etc. You will conduct and oversee all aspects of the method development, troubleshooting, validation, and sample analysis for clinical studies requiring genomic and proteogenomic technologies' endpoints including reagent selection/optimization, sample preparation, sample acquisition and data processing. You will ensure all work is conducted in compliance with GCLP regulations and follows the appropriate SOPs.

Key Responsibilities :

This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following.

• Clinical Genomics/ Proteomics Expert: You will serve as a technical expert in applied genomic and proteogenomic technologies and will generate data to support the understanding of disease heterogeneity, drug's mechanism of action, and patient response to treatment at the molecular level through application of advanced genomic/ proteomic technologies, including Next Generation Sequencing (NGS), Olink PEA assays, qPCR, dd-PCR etc.

• Innovation: Evaluation of novel genomics/ proteomic techniques and technologies (i.e. single cell RNA-Seq, Olink PEA) to inform biomarker development and validation. Working in a matrix environment, identify and execute the validation of assays using human cells and tissues to enhance human translation and predictive value.

• Disease Biomarker Assay Development: You will conduct and oversee all aspects of the method development, troubleshooting, validation, and sample analysis for clinical studies requiring genomic technologies endpoints including reagent selection/optimization, sample preparation, sample acquisition and data processing. You will ensure that all work is conducted in compliance with GCLP regulations and follows the appropriate SOPs.

• Cross-functional Collaboration: Collaborate closely with cross-functional teams including Translational Research, Translational Sciences, Clinical Biomarkers, RIRU Disease Teams, biology groups, platforms, HBSM, Precision Medicine, data-sciences and regulatory affairs, to provide scientific expertise and guidance to support decision-making and project progression.

• External Partnerships: Support strategic collaborations with academic institutions, contract research organizations (CROs), and other external partners to act as SME for cutting-edge technologies, tools, reagents, bio-samples, biomarker expertise, and research capabilities

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:
  • Ph.D. in a relevant scientific discipline (e.g., Biochemistry, Cell/Molecular Biology, Genetics, Genomics, proteomics or related field) with minimum 1-2 years post-PhD experience or a B.S./M.S. degree with 5-10 years post-graduation experience in genomics, NGS, molecular or cellular biology, biomedical science, or related disciplines.


• Scientific experience with current genomic analytical platforms (e.g., Single Cell RNA-Seq, RNA-Seq, Proteogenomic, qPCR, dd-PCR etc.).

• Experience supporting the design and interpretation of data from several of the following methods/assays: DNA and RNA sequencing technologies, Olink PEA Assays, single cell sequencing, and other emerging genomics/ proteogenomic technologies and commercial platforms.

• Experience in designing, troubleshooting, and implementing Olink PEA assays, single cell RNA-Seq applications (e.g., 10x Genomics, BD Rhapsody, Parse), or similar high content techniques.

• Experience and understanding in the use of genomics analysis software IGV Browser, Genome Browser, Illumina DRAGEN, CLC Genomics Workbench

• Experience working with the drug development process.

• Experience working in a cross functional team matrix environment with colleagues from all phases of clinical drug development and influence biomarker testing strategies

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• Hands on experience with the Next Generation Sequencers (Illumina, ONT, PacBio), Hamilton (or equivalent), Mosquito, Dragonfly, F.A.S.T. and other automated liquid handlers, single cell immuno-genomics workflows such as CITE-Seq, etc.
  • Experience working with flow cytometry and histotechnology to lead cross-platform genomics projects (e.g., CITE-Seq, TCR/BCR Seq, Spatial Transcriptomics, etc.).
  • Demonstrated judgment and decision making, especially for prioritizing multiple requests.
  • Ability to maintain a disciplined approach, ensuring a relentless focus on quality, compliance, scientific rigor, and operational excellence.


• Attention to detail, excellent communication and interpersonal skills, with the ability to effectively communicate complex scientific concepts to both technical and non-technical audiences in a balanced, clear and precise manner.

• Proactively demonstrate the ability to work to tight deadlines, both independently and in a team.

• Highly motivated team player with a proactive attitude and ability to interact effectively within a multi-disciplinary team.

• Generate high quality data to support clinical studies by various NGS platforms.

• Hands on experience with single cell immuno-genomics workflows such as CITE-Seq and AbSeq (e.g., sample preparation, NGS, data QC).

• Experience to handle human biological samples and perform experimental work in accordance with safety requirements, data integrity and GCLP guidelines.

• Collaborate with Biomarker Leads and provide biomarker assay support to deliver on biomarker strategy as defined by project needs.

• Develop genomic and proteogenomic assays using applied genomic technologies to support translational and clinical studies, delivery of robust, high quality data packages.

• Work with data management, programming, and bioinformatics scientists to expedite the transfer of biomarker data to clinical teams.

• Deliver, interpret, and communicate complex, high quality scientific data to project/program teams within agreed timelines.

• Strong project management skills, with the ability to prioritize and manage multiple projects to meet timelines while maintaining attention to detail and high-performance standards.

• Contribute to translational biomarker strategy and capital equipment discussions.

• Act as subject matter expert for the transfer of assays to CROs.

• Help lead efforts to investigate novel genomics and data analysis platforms and imbed within the organization.

• Willingness to develop and train others as required.

#LI-GSK

Please visit GSK US Benefits Summary t o learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

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