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Scientific Director

3 months ago

Indianapolis, Indiana, United States Eli Lilly and Company Full time

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

Due to a strategic commitment to the growth of biotherapeutics within the Lilly portfolio, multiple opportunities are currently available within the Bioproduct Research and Development (BR&D) organization. This group is a multidisciplinary organization, focused on the development and commercialization of parenteral formulations of small molecules and large molecules such as monoclonal antibodies, novel therapeutic proteins and peptides. The organization has also committed to the development of genetic medicines which includes active investments in Oligonucleotide development, nanomedicines for tissue specific targeting and other gene delivery strategies. The drug product team is also investing in building new platforms to support complex formulations such as lipid nanoparticles, Antibody Drug Conjugates and AAV and other non-viral vector delivery.

We are seeking highly motivated professionals with an experience in developing and commercializing parenteral drug product through various stages of clinical development. If you are interested in building platforms for new and novel therapeutic modalities and interested in building and leading a strong group of scientists exploring new frontiers into formulation and drug delivery strategies, you should consider joining our diverse team.

Level is flexible based on experience and qualification.

KEY OBJECTIVES/DELIVERABLES:

The responsibilities for this role will include:

Represent Drug Product team in CM&C teams and support the formulation and process development of protein, peptide, oligonucleotides and other novel modalities in clinical developmentBuild new formulation technologies to support clinical development of novel parenteral drug product and other complex formulationsBuild process capabilities for lab scale, early phase clinical scale, and scale up technologies for novel parenteral drug product and other complex formulationsSupport tech transfer of process and formulation to clinical manufacturing sites.Work closely with synthetic chemistry, toxicology, ADME groups, analytical teams and device teams to develop the drug product that is stable and patient centric.May need to support monoclonal antibody, proteins and peptide programs in various stages of development.Ability to lead others in the design, execution and interpretation of experiments to drive the definition and optimization of formulationsCollaborate with Discovery teams on establishing systems for seamless handoff of assets from discovery to clinical development.Innovate or assess cutting edge formulation methodologies for complex or unstable bioproducts (peptides, proteins, fusion proteins and drug conjugates)Identify and spearhead research efforts on understanding new drug delivery technologies in the areas of targeted drug delivery and other novel drug delivery fields, and establish proof of concept for technologies for appropriate assets under developmentEstablish and leverage strategic relationships with academia and start-ups to accelerate and access emerging innovation.Drive a strong innovation agenda for the team leading to publications, presentations and industry wide influenceAbility to wear multiple functional hats so that input into various complementary parts of the project can be managed in a rapid and localized mannerCoaching, training and administration of performance management to personnel (primarily, but not limited to, direct reports)BASIC QUALIFICATIONS:PhD in Pharmaceutics or Pharmaceutical Sciences or Biochemistry or Chemical Engineering or related field7 to 15 years of experience in the pharmaceutical or biotech industry in developing formulation technologies or drug delivery technologies to support early /late- phase clinical program.Preparation of control strategy and regulatory submissions supporting clinical development.Experience with supervision of scientists and engineers.Skills and PreferencesComprehensive knowledge and understanding of (1) traditional and new modalities of parenteral drug product development (2) parenteral manufacturing and aseptic technologies, and drug product process development.Background encompasses both innovation and technical development of oligos, protein, peptide, viral or cell therapeutics.Proven record of developing processes and deep understanding of principles and analytical techniques necessary to characterize proteinaceous materials and/or oligonucleotides, AAVs.Technical leadership in the areas of formulation and drug delivery.Extensive experience collaborating with key patterner functions, including discovery, and drug product delivery and device to develop innovative solutions with a patient focus in an integrated fashion. Comprehensive knowledge and understanding of (1) traditional and new modalities of parenteral drug product development (2) parenteral manufacturing and aseptic technologies, and drug product process development. Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively "Lilly") are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women's Network, Working and Living with Disabilities. Learn more about all of our groups. #WeAreLilly