Associate Director/Director, Cheminformatics

4 weeks ago

Boston, Massachusetts, United States Matchpoint Therapeutics Full time

Matchpoint is a biotechnology company harnessing the power of covalency to discover precision covalent medicines to transform the treatment of immune diseases and other serious illnesses. The company's proprietary Advanced Covalent Exploration (ACE) platform integrates advanced chemoproteomics, machine learning and covalent chemistry library evolution. Matchpoint has an emerging pipeline of novel covalent medicines initially focused on immunology.

Founded in 2021 by Atlas Venture and Access Biotechnology together with leading scientists from the Dana Farber Cancer Institute and Stanford, we are rapidly growing our team and looking for passionate, driven, and creative thinkers to join us in ushering in a new era of covalent medicines.


Position Summary

Matchpoint Therapeutics is looking for a talented, driven cheminformatician with a proven track record in advancing drug discovery pipelines. The successful candidate will have extensive experience in cheminformatics; using state-of-the-art deep learning/machine learning (DL/ML) tools in developing models that impact programs. Additional experience is in applying DL/ML techniques to generative molecular designs, use of cheminformatic tools to analyze chemoproteomics data, and in analysis of DEL experiments is highly preferred.

The successful candidate will partner with Matchpoint's leadership team to develop and execute on a vision and strategy for state-of-the-art cheminformatic tools in covalent small molecule drug discovery. The incumbent will collaborate with multidisciplinary colleagues across the research team, as well as with external scientific domain experts, and have the skills to influence and manage science both internally
and externally.

Key Responsibilities / Essential Functions

  • Partner with leadership team to set vision and strategy for cheminformatics as it applies to drug discovery and chemoproteomics platform
  • Develop and deploy DL/ML models for drug discovery projects
  • Analyze in vitro and ADME properties to inform improved design in covalent drug discovery programs
  • Drive molecular design by working closely with internal and external computational chemistry colleagues
  • Develop and deploy analysis and visualization tools for medicinal and computational chemists, as well as for chemoproteomics experiments

Qualifications/ Year(s) of Experience / Education Requirements / Competencies

  • Ph.D. or equivalent in physical chemistry, organic, computational chemistry, cheminformatics, physics, and/or computer science
  • 8+ years of cheminformatics experience in biotech/pharma
  • Proven track record of impact and innovation as evidenced by authorship and/or inventorship
  • Ability to communicate results and proposals to all levels of the organization and to influence molecule design and med chem program strategy
  • Ability to work effectively in a globe-spanning virtual team and adjust priorities as required to meet evolving company needs and deadlines
  • Previous experience contributing to covalent drug discovery is desirable

We offer a competitive compensation package, including equity-based compensation, annual bonus potential, healthcare benefits, 401(k), parking, and flexible paid time-off.

Matchpoint is an equal opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, marital or veteran status, disability, or any other legally protected status.

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