Sr. Scientist, Protein Engineering

3 weeks ago


Palo Alto, United States Inograft Biotherapeutics, Inc. Full time

ABOUT INOGRAFT BIO

Inograft Bio is a preclinical-stage biotechnology company focused on the development of best-in-class non-genotoxic bone marrow conditioning regimens for bone marrow transplantation. Formed in late 2022, with founders from Stanford University School of Medicine and Forty Seven Inc. (acquired by Gilead in 2020 for $4.9B), Inograft Bio aims to develop life-changing therapies by applying proven stem cell therapies to areas of significant unmet medical need, including genetic disorders, autoimmune diseases, aging, and organ transplant.


JOB DESCRIPTION

We are seeking a highly skilled, insightful, and energetic team player to be a crucial member of the Protein Engineering group. The Senior Scientist will perform most of our novel recombinant protein purification and biophysical analysis. This researcher will also be responsible for lot storage and excellent record keeping of all drugs made in-house and by external CROs. This role involves collaborating with protein design, molecular and cellular biology, and immunology to create novel recombinant drugs with acceptable yields, stable biophysical characteristics, and optimally potent biological activity.


KEY RESPONSIBILITIES

  • Purify endotoxin-free proteins from mammalian cell supernatants or E. coli lysates via Protein A/G/L, nickel-NTA, and affinity along with other isolation methods (IEX, SEC, HIC, etc.)
  • Perform biophysical analysis and characterization including PAGE, SEC, IEF, BLI thermostability, etc.
  • Keep excellent records of all purified lots and maintain detailed and up to date electronic notebooks
  • Coordinate and collaborate with rest of the team to create and develop novel protein drugs
  • Oversee CROs that provide recombinant protein production, biophysical analysis, mass-spec, and other protein science services


SKILLS AND QUALIFICATIONS

  • BS+10/MS+8/PhD+5 in Biochemistry, Chemistry, Biology, or related fields
  • Extensive experience in protein sciences, in particular purification and biophysical characterization
  • Prior experience working with multi-targeting molecules, cell engagers, and other similar Ig-based molecules a plus
  • Formulation, process development, and prior experience in technology transfer with CMC a plus


The anticipated salary range for this position is $163K to $183K. The actual salary will be dependent on various factors that may include experience level, knowledge, skills and abilities.


Inograft Bio offers a competitive salary and benefits package.


Please submit resumes to careers@inograft.com.



  • Palo Alto, United States Inograft Biotherapeutics, Inc. Full time

    ABOUT INOGRAFT BIOInograft Bio is a preclinical-stage biotechnology company focused on the development of best-in-class non-genotoxic bone marrow conditioning regimens for bone marrow transplantation. Formed in late 2022, with founders from Stanford University School of Medicine and Forty Seven Inc. (acquired by Gilead in 2020 for $4.9B), Inograft Bio aims...


  • Palo Alto, United States The Carnegie Institution For Science's Plant Biology And Global Ecology Full time

    Home › Jobs Listing › Job: Data Scientist/Research Software Engineer/Postdoctoral Fellow Position Summary : Work with biologists to identify sequences that target proteins to chloroplasts and mitochondria, with particular interest in developing informatic methods to determine those proteins that are targeted, simultaneously, to both chloroplasts and...


  • Palo Alto, California, United States International Flavors and Fragrances Full time

    Job OverviewWe are seeking a talented Product Development Scientist to join our team at International Flavors and Fragrances. As a key member of our product development group, you will be responsible for developing value-creating solutions for project teams and stakeholders.About the RoleThis is a bench-focused position working on liquid formulations of...


  • Palo Alto, United States Arc Institute Full time

    About Arc Institute The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new...


  • Palo Alto, California, United States Amazon Full time

    About the RoleAt Amazon, we're looking for a highly skilled Data Scientist Analytics Engineer to join our AWS Analytics Science team. As part of this role, you'll have the opportunity to apply your expertise in machine learning, program analysis, and databases to impact some of the largest analytics services in the industry.


  • Palo Alto, United States Arc Institute Full time

    About Arc Institute The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new...


  • Palo Alto, California, United States Amazon Full time

    Amazon's commitment to delivering exceptional customer experiences has led us to seek a skilled Sr. Software Development Engineer to join our Search Relevance team. As a key member of this team, you will contribute to the design and development of large scale search systems that power our global customer base.The Search Relevance team is tasked with creating...


  • Palo Alto, United States Inograft Biotherapeutics, Inc. Full time

    ABOUT INOGRAFT BIOInograft Bio is a preclinical-stage biotechnology company focused on the development of best-in-class non-genotoxic bone marrow conditioning regimens for bone marrow transplantation. Formed in late 2022, with founders from Stanford University School of Medicine and Forty Seven Inc. (acquired by Gilead in 2020 for $4.9B), Inograft Bio aims...

  • AI Scientist

    3 weeks ago


    Palo Alto, United States Salesforce Full time

    AI Scientist Job Description Salesforce is the global leader in Cloud-based (SaaS) solutions that enable the world’s premier brands to maintain a robust online presence with high ROI. We do that by providing a highly scalable, integrated cloud platform that allows our clients to rapidly launch and manage multiple e-commerce stores, initiate unique...

  • AI Scientist

    3 weeks ago


    Palo Alto, United States Salesforce Full time

    AI Scientist Job Description Salesforce is the global leader in Cloud-based (SaaS) solutions that enable the world’s premier brands to maintain a robust online presence with high ROI. We do that by providing a highly scalable, integrated cloud platform that allows our clients to rapidly launch and manage multiple e-commerce stores, initiate unique...


  • Palo Alto, California, United States Amazon Full time

    At Amazon, we are committed to providing our customers with the best search experience possible. As a Sr. Software Development Engineer, you will play a critical role in designing and developing large scale search systems that cater to the needs of millions of users worldwide.The Search Relevance team is seeking a strong software engineer to join their ranks...

  • Materials Scientist

    2 days ago


    Palo Alto, California, United States Tesla Full time

    Role OverviewWe are seeking a highly skilled Materials Scientist to join our team at Tesla. As a key member of our Cell Materials Engineering group, you will be responsible for leading the development, testing, and validation of binders and polymer additives for our Li-ion cells.About the RoleThis is an exciting opportunity for a talented professional with a...


  • PALO ALTO, United States KOHLER Full time

    Kohler Co. seeks Sr. Software Quality Engineers for its Palo Alto, CA location to work directly with the Head of Software, software/hardware engineering team, and product teams. Build the forward-looking vision and lead the effort to ensure the entire development lifecycle takes a quality first approach. Employer will accept a Bachelor’s degree, or foreign...


  • Palo Alto, United States Amazon Full time

    Sr. Machine Learning Engineer, AGI FoundationsJob ID: 2860903 | Amazon.com Services LLCThe Artificial General Intelligence (AGI) team is looking for a passionate, talented, and inventive Senior SDE with a strong machine learning background, to lead the development of industry-leading models with multimodal systems.As a Senior SDE with the AGI team, you will...


  • Palo Alto, California, United States Pinterest Job Advertisements Full time

    Pinterest Job Overview:We're looking for a highly skilled Data Scientist to join our team. As a Data Scientist, you will be responsible for contributing to each step of the product development process, from ideation to implementation to release. You will work on building products and features that enable visually rich experiences and design and develop...


  • Palo Alto, United States Amazon Full time

    We are looking for an experienced Sr. Data Scientist to lead ML and LLM based signals development and data analytics and drive critical product decisions for Amazon Search. In a fast-paced and ambiguous environment, you will perform multiple large, complex, and business critical analyses that will inform product design and business priorities. You will...


  • Palo Alto, California, United States Amazon Full time

    Job Description">We are looking for a talented Applied Scientist to join our team, working on state-of-the-art AI projects. Your primary responsibility will be to develop and implement algorithms for our LLM solutions, collaborating with cross-functional teams to ensure successful project delivery.">Key Responsibilities">Develop and implement algorithms for...

  • Research Scientist

    3 days ago


    Palo Alto, California, United States Centrillion Technology Holdings Full time

    Job Title: Research ScientistLocation: Palo Alto, CASalary: $120,000 - $150,000 per year">About Us: Centrillion Technology Holdings is a cutting-edge biotechnology company leveraging engineering and biochemistry breakthroughs to accelerate discovery. Our team of scientists and engineers is committed to making transformative genomic technologies accessible...


  • Palo Alto, California, United States SynergisticIT Full time

    About UsSynergisticIT is a renowned technology consulting firm that has been helping job seekers achieve their career goals since 2010. Our team of experts provides candidates with the necessary skills and experience to excel in the tech industry.Estimated Salary: $100,000 - $150,000 per yearJob DescriptionWe are currently looking for entry-level software...


  • Palo Alto, United States Stanford University Full time

    Research and Development Scientist and EngineerNote - This is a one-year, fixed-term position.The School of EngineeringStanford Engineering has been at the forefront of innovation for nearly a century, creating pivotal technologies that have transformed the worlds of information technology, communications, health care, energy, business, and beyond. Our...