Principal Scientist, Translational Research

5 days ago

Palo Alto, United States Inograft Biotherapeutics, Inc. Full time

ABOUT INOGRAFT BIO

Inograft Bio is a preclinical-stage biotechnology company focused on the development of best-in-class non-genotoxic bone marrow conditioning regimens for bone marrow transplantation. Formed in late 2022, with founders from Stanford University School of Medicine and Forty Seven Inc. (acquired by Gilead in 2020 for $4.9B), Inograft Bio aims to develop life-changing therapies by applying proven stem cell therapies to areas of significant unmet medical need, including genetic disorders, autoimmune diseases, aging, and organ transplant.


JOB DESCRIPTION

Inograft is seeking a highly self-motived, intellectually capable, collaborative physician and/or scientist to join and eventually lead a team of scientists within our translational research division. The Principal Scientist- Translational Research will play a critical role in guiding the development of our novel bone marrow conditioning regimen into its true potential as a practical clinical modality. This role will require the incorporation of continually evolving data from our passionate multidisciplinary teams, including basic scientists, protein engineers, and translational scientists into non-human primate proof-of concept studies and ultimately into IND-enabling studies. As such, this individual will need to have sufficient diversity of experience and exposure to these various areas to comfortably communicate with these groups. Successful execution of this role’s responsibilities will also require the continuous balancing of the basic science approach with the practicality required for CROs studies and clinical translation. The candidate will have significant potential for professional growth as many of Inograft’s needs are novel and fast-paced.


KEY RESPONSIBILITIES

The Principal Scientist will be primarily responsible for driving an internal team towards experimental goals and interacting with multiple internal teams. Some coordinating with external Contract Research Organizations (CROs) to execute studies related to non-human primates will be required. This role will require expertise in laboratory techniques, data analysis, and scientific communication to support the development and advancement of key research projects. Specific areas of responsibility include:

  • Flow Cytometry Panel Development: Develop and optimize high-parameter flow cytometry panels for characterizing various subsets of hematopoietic cells, including mature cells, progenitor cells, and hematopoietic stem cells (HSCs). This involves customizing panels for specific research purposes and ensuring compatibility across different cytometry platforms (e.g. BD and Beckman Coulter)
  • Experimental Design and Execution: Plan, design, and conduct laboratory experiments to support research objectives. This includes troubleshooting technical issues, ensuring reproducibility, and documenting all procedures for accurate tracking and reporting
  • Data Analysis and Interpretation: Perform in-depth analysis of flow cytometry data, with the ability to identify and interpret complex data patterns. Ensure data quality and accuracy through rigorous analysis, and apply advanced statistical techniques as needed
  • Team Supervision and Collaboration: Provide mentorship and supervision to junior scientists and research associates. Facilitate a collaborative environment that fosters skill development, and encourage best practices in laboratory research and data integrity
  • Assay Development: Design receptor occupancy PK or other assays to determine the interaction dynamics of drug candidates with their biological targets
  • Cross-functional Communication: Regularly communicate progress, findings, and challenges to internal teams and external CROs. This includes preparing technical reports, presenting data to stakeholders, and adapting scientific language for diverse audiences
  • Laboratory and Safety Compliance: Ensure all experimental work adheres to laboratory safety standards and regulatory guidelines. Maintain a clean and organized lab environment and promote safety protocols among team members


Preferred Additional Experience:

  • Strong problem-solving and critical-thinking abilities
  • Designing, planning, and executing translational research projects in collaboration with internal cross-functional teams and external CROs
  • Selecting of CROs for supporting studies (e.g. flow cytometry and PK studies) as well as approval of internal and external assays for transfer to CROs
  • Participating in multi-disciplinary analysis and interpretation of data to derive meaningful insights to drive critical decision making
  • Preparing documents and presentations for FDA and other regulatory agencies
  • Establishing and maintaining relationships with external academic collaborators and scientific advisory board members


REQUIRED QUALIFICATIONS

  • MD and/or PhD degree in a relevant field (e.g. immunology, stem cell biology, or bone marrow transplantation)
  • 8+ years of relevant experience in biotech/pharma industry
  • Extremely strong foundation with multicolor flow cytometry
  • Strong background in basic research, especially hands-on experience in designing and conducting animal studies – NHP experience would be preferred
  • Comfort with innovative problem solving for novel issues
  • Ability to work independently and as the lead for cross-functional teams
  • Ability to travel to animal research centers to plan and observe/supervise NHP studies


PREFERRED SKILLS

  • Familiarity with stages of drug development, including discovery, IND-enabling, and clinical
  • Experience in drafting animal study protocols in compliance with IACUC and other state and federal oversight guidelines


The anticipated salary range for this position is $183,000 to $205,000. The actual salary may vary based on various factors including but not limited to experience level, knowledge, relevant skills and qualifications.


Inograft offers a competitive salary and benefits package.


Please submit resumes to careers@inograft.com.

  • Principal Applied Scientist

    1 month ago

    Palo Alto, United States Amazon Development Center U.S., Inc. - B02 Full time

    Ph.D. degree in Statistics, Computer Science, Applied Math, or a related field with publications in refereed academic journals 7+ years of hands-on experience in solving difficult machine learning problems Expert at more than one major programming languages (C++, Java, or similar) and at least one scripting language (Perl, Python, or similar) Demonstrated...

  • Senior Research Scientist

    1 week ago

    Palo Alto, California, United States Stanford Blood Center Full time

    Job OverviewStanford University seeks a highly skilled Senior Research Scientist to join its Department of Emergency Medicine. This is a fixed-term, 3-year position with the possibility of renewal at 100% FTE.About the RoleThe Senior Research Scientist will play a key role in advancing the department's research activities, contributing to cutting-edge...

  • Principal Data Scientist

    4 weeks ago

    Palo Alto, United States Salesforce, Inc. Full time

    Do you want to be at the forefront of a team at Salesforce that is making history? Do you want to build technology and new science that millions of people will use? Are you excited about working on large scale Generative AI, Natural Language Processing (NLP), and Deep Learning?Salesforce, the world’s #1 AI CRM, has recently unveiled Agentforce, a...

  • Senior Research Scientist

    2 days ago

    Palo Alto, CA, United States Stanford University Full time

    Fixed-term, 3 years (renewable) @ 100% FTE The Department of Emergency Medicine is seeking a Senior Research Scientist. The Senior Research Scientist will be involved directly in the execution of the Department's research activities. Emergency Medicine is a rapidly-developing field, and Stanford is leading research in many facets of care. The department...

  • Data Scientist Lead

    1 week ago

    Palo Alto, California, United States Stanford University Full time

    **Job Title:** Data Scientist Lead - Emergency CareCompany OverviewStanford University seeks a highly skilled and experienced Senior Research Scientist to join our Department of Emergency Medicine. This is a 3-year fixed-term position at 100% FTE.SalaryThe estimated salary for this role is $160,000 per annum, commensurate with experience.Job DescriptionAs a...

  • AI Scientist

    7 days ago

    Palo Alto, United States Salesforce Full time

    AI Scientist Job Description Salesforce is the global leader in Cloud-based (SaaS) solutions that enable the world’s premier brands to maintain a robust online presence with high ROI. We do that by providing a highly scalable, integrated cloud platform that allows our clients to rapidly launch and manage multiple e-commerce stores, initiate unique...

  • AI Scientist

    7 days ago

    Palo Alto, United States Salesforce Full time

    AI Scientist Job Description Salesforce is the global leader in Cloud-based (SaaS) solutions that enable the world’s premier brands to maintain a robust online presence with high ROI. We do that by providing a highly scalable, integrated cloud platform that allows our clients to rapidly launch and manage multiple e-commerce stores, initiate unique...

  • Deep Learning Research Scientist

    7 days ago

    Palo Alto, California, United States Salesforce Full time

    Role OverviewWe are seeking an exceptional Deep Learning Research Scientist to join our team at Salesforce. As a research scientist, you will play a crucial role in advancing the state of the art in AI and driving innovation in large-scale Generative AI, Natural Language Processing (NLP), and Deep Learning.About the RoleThis is a unique opportunity to work...

  • Senior AI Research Scientist

    6 days ago

    Palo Alto, California, United States salesforce, inc. Full time

    OverviewSalesforce, the world's leading customer relationship management platform, is driving innovation in the field of Artificial Intelligence. Our cutting-edge technology has led to the development of Agentforce, a groundbreaking suite of autonomous AI agents that augment employees and handle tasks in service, sales, marketing, and commerce.We are seeking...

  • Brain Research Scientist: Synapse Dynamics

    7 days ago

    Palo Alto, California, United States Raymond Laboratory of Neurobiology at Stanford University Full time

    We are seeking a skilled Brain Research Scientist to contribute to our ongoing research on synapse dynamics in learning and memory. The successful candidate will be part of a dynamic team at the Raymond Laboratory of Neurobiology at Stanford University, utilizing molecular, cellular, systems, behavioral, and computational approaches to uncover the rules...

  • Principal Data Scientist

    4 weeks ago

    Palo Alto, United States salesforce.com, inc. Full time

    To get the best candidate experience, please consider applying for a maximum of 3 roles within 12 months to ensure you are not duplicating efforts.Job CategoryDataJob DetailsAbout SalesforceWe're Salesforce, the Customer Company, inspiring the future of business with AI + Data + CRM. Leading with our core values, we help companies across every industry blaze...

  • Principal Data Scientist

    4 weeks ago

    Palo Alto, United States Salesforce Full time

    About Salesforce We’re Salesforce, the Customer Company, inspiring the future of business with AI + Data + CRM. Leading with our core values, we help companies across every industry blaze new trails and connect with customers in a whole new way. And, we empower you to be a Trailblazer, too — driving your performance and career growth, charting new paths,...

  • Principal Data Scientist

    1 week ago

    Palo Alto, California, United States HP Full time

    Job DescriptionHP seeks a highly skilled Data Scientist to join the Workforce Experience Platform team. This role involves leveraging AI/ML to drive innovation and deliver stellar customer experiences using one of the largest data lakes in the world.Responsibilities:Collaborate with product management to understand product vision and user engagement...

  • AI Innovation Researcher

    1 week ago

    Palo Alto, California, United States Amazon Full time

    Join Amazon's LLM TeamWe're searching for pioneers who are passionate about technology, innovation, and customer experience.About the RoleThis is a unique opportunity to work with talented scientists and engineers across Amazon Shopping and AGI to innovate on behalf of our customers.Key ResponsibilitiesDevelop machine learning models for business...

  • Data Scientist

    7 days ago

    Palo Alto, California, United States Salesforce Inc Full time

    About SalesforceSalesforce is a global leader in customer relationship management technology. We empower businesses of all sizes and industries to succeed in today's digital landscape by providing innovative solutions for sales, marketing, and customer service.Job DescriptionWe are seeking an exceptional Data Scientist - AI Researcher to join our team at...

  • AI Research Scientist for Legal Innovation at Stanford University

    1 week ago

    Palo Alto, California, United States Stanford University Full time

    About the RoleWe are seeking a highly skilled AI Research Scientist to join our team at Stanford University's Law School. The successful candidate will be responsible for executing and administering research activities on AI and other legal technological developments.

  • Research and Development Scientist and Engineer

    3 weeks ago

    Palo Alto, United States Stanford University Full time

    Research and Development Scientist and EngineerNote - This is a one-year, fixed-term position.The School of EngineeringStanford Engineering has been at the forefront of innovation for nearly a century, creating pivotal technologies that have transformed the worlds of information technology, communications, health care, energy, business, and beyond. Our...

  • Data Scientist

    7 days ago

    Palo Alto, California, United States OPPO US Research Center Full time

    Role OverviewAs a key member of the OPPO US Research Center's Research and Development team, we are seeking a highly skilled Data Scientist to join our technology innovation leadership team. In this position, you will play a crucial role in enhancing the user experience of our AI products by leveraging data-driven insights to address significant business...

  • Senior Data Scientist

    1 week ago

    Palo Alto, California, United States OPPO US Research Center Full time

    About the RoleOPPO US Research Center seeks a talented Data Scientist to join our Research and Development team, focusing on AI product optimization and user growth. As a key member of our technology innovation leadership team, you will play a crucial role in improving user experience and addressing significant business challenges.Responsibilities:Gather,...

  • Senior Principal Applied Scientist, Rufus | Mastering AI-Driven Shopping Experiences

    7 days ago

    Palo Alto, California, United States Amazon Full time

    Job DescriptionWe are seeking a highly skilled Senior Principal Applied Scientist to lead our Search Experience Science team at Amazon. As the technical lead, you will be responsible for designing and implementing architectural advancements of Rufus, our next-generation AI-driven search and shopping assistant.About the RoleYou will leverage your expertise in...